The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Adenylosuccinate Synthetase, subunit A, domain 3
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Adenylosuccinate synthetase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
188 P0A7D4 (/IPI) P0A7D4 (/IPI) P0A7D4 (/IPI) P0A7D4 (/IPI) P0A7D4 (/IPI) P0A7D4 (/IPI) P0A7D4 (/IPI) P0A7D4 (/IPI) P0A7D4 (/IPI) P0A7D4 (/IPI)
(178 more)
Adenylosuccinate synthase activity GO:0004019
Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate.
187 D4AEP0 (/IDA) M0R629 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA)
(177 more)
Adenylosuccinate synthase activity GO:0004019
Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate.
30 A4Z6H0 (/ISS) A5PJR4 (/ISS) Q561L1 (/ISS) Q561L1 (/ISS) Q68F20 (/ISS) Q68F20 (/ISS) Q6DIW6 (/ISS) Q6NSN5 (/ISS) Q8EHG3 (/ISS) Q8IDF6 (/ISS)
(20 more)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
14 Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS)
(4 more)
Adenylosuccinate synthase activity GO:0004019
Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate.
5 P80210 (/IMP) P80210 (/IMP) P80210 (/IMP) P80210 (/IMP) Q8N142 (/IMP)
DNA replication origin binding GO:0003688
Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.
4 P80210 (/IDA) P80210 (/IDA) P80210 (/IDA) P80210 (/IDA)
Adenylosuccinate synthase activity GO:0004019
Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate.
4 P28650 (/ISO) P28650 (/ISO) P46664 (/ISO) P46664 (/ISO)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
3 P30520 (/NAS) P30520 (/NAS) Q8N142 (/NAS)
Phosphate ion binding GO:0042301
Interacting selectively and non-covalently with phosphate.
3 P30520 (/NAS) P30520 (/NAS) Q8N142 (/NAS)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
2 P28650 (/ISO) P28650 (/ISO)
Adenylosuccinate synthase activity GO:0004019
Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate.
2 P30520 (/NAS) P30520 (/NAS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P28650 (/ISO) P28650 (/ISO)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
2 P28650 (/ISO) P28650 (/ISO)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
1 M0R629 (/IDA)
Adenylosuccinate synthase activity GO:0004019
Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate.
1 Q5BEY7 (/RCA)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 P21900 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 M0R629 (/IDA)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 M0R629 (/IDA)
Sulfinylpropanyl adenylate synthase GO:0061483
Catalysis of the reaction: cysteine sulfanate + GTP + IMP = sulfinylpropanyl adenylate + GDP + 3 H(+) + phosphate.
1 Q02787 (/IDA)

There are 37 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Purine nucleotide biosynthetic process GO:0006164
The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
175 P0A7D4 (/IMP) P0A7D4 (/IMP) P0A7D4 (/IMP) P0A7D4 (/IMP) P0A7D4 (/IMP) P0A7D4 (/IMP) P0A7D4 (/IMP) P0A7D4 (/IMP) P0A7D4 (/IMP) P0A7D4 (/IMP)
(165 more)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
170 P0A7D4 (/IEP) P0A7D4 (/IEP) P0A7D4 (/IEP) P0A7D4 (/IEP) P0A7D4 (/IEP) P0A7D4 (/IEP) P0A7D4 (/IEP) P0A7D4 (/IEP) P0A7D4 (/IEP) P0A7D4 (/IEP)
(160 more)
Nucleobase-containing small molecule interconversion GO:0015949
The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule.
170 P0A7D4 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA)
(160 more)
Adenosine biosynthetic process GO:0046086
The chemical reactions and pathways resulting in the formation of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes.
170 P0A7D4 (/IMP) P0A7D4 (/IMP) P0A7D4 (/IMP) P0A7D4 (/IMP) P0A7D4 (/IMP) P0A7D4 (/IMP) P0A7D4 (/IMP) P0A7D4 (/IMP) P0A7D4 (/IMP) P0A7D4 (/IMP)
(160 more)
Purine nucleotide biosynthetic process GO:0006164
The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
15 P21900 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS)
(5 more)
AMP biosynthetic process GO:0006167
The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate.
14 Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS) Q8IDF6 (/ISS)
(4 more)
Purine ribonucleotide biosynthetic process GO:0009152
The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
8 Q8EHG3 (/ISS) Q9KNX8 (/ISS) Q9KNX8 (/ISS) Q9KNX8 (/ISS) Q9KNX8 (/ISS) Q9KNX8 (/ISS) Q9KNX8 (/ISS) Q9KNX8 (/ISS)
AMP biosynthetic process GO:0006167
The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate.
5 P30520 (/IDA) P30520 (/IDA) P46664 (/IDA) P46664 (/IDA) Q8N142 (/IDA)
AMP biosynthetic process GO:0006167
The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate.
4 P28650 (/ISO) P28650 (/ISO) P46664 (/ISO) P46664 (/ISO)
Aspartate metabolic process GO:0006531
The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
4 P28650 (/ISO) P28650 (/ISO) P46664 (/ISO) P46664 (/ISO)
IMP metabolic process GO:0046040
The chemical reactions and pathways involving IMP, inosine monophosphate.
4 P28650 (/ISO) P28650 (/ISO) P46664 (/ISO) P46664 (/ISO)
Immune system process GO:0002376
Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
3 P30520 (/NAS) P30520 (/NAS) Q8N142 (/NAS)
Purine ribonucleoside monophosphate biosynthetic process GO:0009168
The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.
3 P30520 (/TAS) P30520 (/TAS) Q8N142 (/TAS)
Purine nucleotide metabolic process GO:0006163
The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
2 P28650 (/IDA) P28650 (/IDA)
Purine nucleotide biosynthetic process GO:0006164
The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
2 P46664 (/IDA) P46664 (/IDA)
AMP biosynthetic process GO:0006167
The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate.
2 P30520 (/NAS) P30520 (/NAS)
Aspartate metabolic process GO:0006531
The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
2 D4AEP0 (/IDA) M0R629 (/IDA)
Purine ribonucleoside monophosphate biosynthetic process GO:0009168
The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.
2 P28650 (/ISO) P28650 (/ISO)
IMP metabolic process GO:0046040
The chemical reactions and pathways involving IMP, inosine monophosphate.
2 D4AEP0 (/IDA) M0R629 (/IDA)
Cellular response to electrical stimulus GO:0071257
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
2 D4AEP0 (/IEP) M0R629 (/IEP)
Fumarate metabolic process GO:0006106
The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate.
1 Q02787 (/IDA)
Nucleobase-containing compound metabolic process GO:0006139
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
1 Q5BEY7 (/RCA)
Glutamine metabolic process GO:0006541
The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
1 M0R629 (/IEP)
Purine ribonucleoside monophosphate biosynthetic process GO:0009168
The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.
1 M0R629 (/IDA)
Response to purine-containing compound GO:0014074
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus.
1 D4AEP0 (/IEP)
Response to muscle activity GO:0014850
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus.
1 M0R629 (/IEP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 M0R629 (/IEP)
Response to starvation GO:0042594
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
1 M0R629 (/IEP)
'de novo' AMP biosynthetic process GO:0044208
The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP).
1 Q02787 (/IDA)
'de novo' AMP biosynthetic process GO:0044208
The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP).
1 Q02787 (/IMP)
Adenosine biosynthetic process GO:0046086
The chemical reactions and pathways resulting in the formation of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes.
1 Q02787 (/ISO)
Adenosine biosynthetic process GO:0046086
The chemical reactions and pathways resulting in the formation of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes.
1 P21900 (/ISS)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 Q96529 (/IEP)
Muscle cell cellular homeostasis GO:0046716
The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.
1 Q6NSN5 (/IMP)
Skeletal muscle fiber development GO:0048741
The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
1 Q6NSN5 (/IMP)
Response to ammonium ion GO:0060359
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus.
1 D4AEP0 (/IEP)
Cellular response to cadmium ion GO:0071276
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 Q02787 (/IMP)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
175 A0A024R5Q7 (/IDA) A0A024R5Q7 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA) P0A7D4 (/IDA)
(165 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
171 P0A7D4 (/HDA) P0A7D4 (/HDA) P0A7D4 (/HDA) P0A7D4 (/HDA) P0A7D4 (/HDA) P0A7D4 (/HDA) P0A7D4 (/HDA) P0A7D4 (/HDA) P0A7D4 (/HDA) P0A7D4 (/HDA)
(161 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
170 P0A7D4 (/HDA) P0A7D4 (/HDA) P0A7D4 (/HDA) P0A7D4 (/HDA) P0A7D4 (/HDA) P0A7D4 (/HDA) P0A7D4 (/HDA) P0A7D4 (/HDA) P0A7D4 (/HDA) P0A7D4 (/HDA)
(160 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P30520 (/TAS) P30520 (/TAS) P46664 (/TAS) P46664 (/TAS) Q8N142 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 P80210 (/HDA) P80210 (/HDA) P80210 (/HDA) P80210 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 A0A024R5Q7 (/IDA) A0A024R5Q7 (/IDA) P30520 (/IDA) P30520 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P28650 (/IDA) P28650 (/IDA) Q8N142 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P28650 (/ISO) P28650 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P46664 (/ISO) P46664 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P46664 (/ISO) P46664 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P30520 (/HDA) P30520 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q02787 (/HDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 Q96529 (/IDA)
Plastid GO:0009536
Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
1 Q96529 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
1 Q96529 (/IDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 P21900 (/HDA)
Apoplast GO:0048046
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
1 Q96529 (/IDA)
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