The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"set domain protein methyltransferase, domain 1
".
FunFam 1: histone-lysine N-methyltransferase setd3 isoform X...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 10 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
13 |
A9X1D0 (/ISS)
B0VX69 (/ISS)
B0VX69 (/ISS)
B1MTJ4 (/ISS)
B2KI88 (/ISS)
B5FW36 (/ISS)
B7ZUF3 (/ISS)
C1FXW2 (/ISS)
E2RBS6 (/ISS)
Q5ZML9 (/ISS)
(3 more) |
|
Histone methyltransferase activity (H3-K36 specific) GO:0046975
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group onto lysine at position 36 of the histone H3 protein.
|
13 |
A9X1D0 (/ISS)
B0VX69 (/ISS)
B0VX69 (/ISS)
B1MTJ4 (/ISS)
B2KI88 (/ISS)
B5FW36 (/ISS)
B7ZUF3 (/ISS)
C1FXW2 (/ISS)
E2RBS6 (/ISS)
Q5ZML9 (/ISS)
(3 more) |
|
Protein-histidine N-methyltransferase activity GO:0018064
Catalysis of the reaction: S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein N-methyl-L-histidine.
|
11 |
A9X1D0 (/ISS)
B0VX69 (/ISS)
B0VX69 (/ISS)
B1MTJ4 (/ISS)
B2KI88 (/ISS)
B5FW36 (/ISS)
B7ZUF3 (/ISS)
C1FXW2 (/ISS)
E2RBS6 (/ISS)
Q5ZML9 (/ISS)
(1 more) |
|
Protein-histidine N-methyltransferase activity GO:0018064
Catalysis of the reaction: S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein N-methyl-L-histidine.
|
3 | G3V6U9 (/IDA) Q86TU7 (/IDA) Q86TU7 (/IDA) |
|
Histone methyltransferase activity (H3-K36 specific) GO:0046975
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group onto lysine at position 36 of the histone H3 protein.
|
2 | Q7SXS7 (/IDA) Q91WC0 (/IDA) |
|
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
1 | Q91WC0 (/IPI) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | Q7SXS7 (/IDA) |
|
Protein-histidine N-methyltransferase activity GO:0018064
Catalysis of the reaction: S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein N-methyl-L-histidine.
|
1 | Q91WC0 (/IMP) |
|
Protein-histidine N-methyltransferase activity GO:0018064
Catalysis of the reaction: S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein N-methyl-L-histidine.
|
1 | Q91WC0 (/ISO) |
|
Histone methyltransferase activity (H3-K4 specific) GO:0042800
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein.
|
1 | Q91WC0 (/IDA) |
There are 25 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Histone H3-K36 methylation GO:0010452
The modification of histone H3 by addition of one or more methyl groups to lysine at position 36 of the histone.
|
13 |
A9X1D0 (/ISS)
B0VX69 (/ISS)
B0VX69 (/ISS)
B1MTJ4 (/ISS)
B2KI88 (/ISS)
B5FW36 (/ISS)
B7ZUF3 (/ISS)
C1FXW2 (/ISS)
E2RBS6 (/ISS)
Q5ZML9 (/ISS)
(3 more) |
|
Peptidyl-lysine trimethylation GO:0018023
The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine.
|
13 |
A9X1D0 (/ISS)
B0VX69 (/ISS)
B0VX69 (/ISS)
B1MTJ4 (/ISS)
B2KI88 (/ISS)
B5FW36 (/ISS)
B7ZUF3 (/ISS)
C1FXW2 (/ISS)
E2RBS6 (/ISS)
Q5ZML9 (/ISS)
(3 more) |
|
Peptidyl-lysine monomethylation GO:0018026
The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine.
|
13 |
A9X1D0 (/ISS)
B0VX69 (/ISS)
B0VX69 (/ISS)
B1MTJ4 (/ISS)
B2KI88 (/ISS)
B5FW36 (/ISS)
B7ZUF3 (/ISS)
C1FXW2 (/ISS)
E2RBS6 (/ISS)
Q5ZML9 (/ISS)
(3 more) |
|
Peptidyl-lysine dimethylation GO:0018027
The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine.
|
13 |
A9X1D0 (/ISS)
B0VX69 (/ISS)
B0VX69 (/ISS)
B1MTJ4 (/ISS)
B2KI88 (/ISS)
B5FW36 (/ISS)
B7ZUF3 (/ISS)
C1FXW2 (/ISS)
E2RBS6 (/ISS)
Q5ZML9 (/ISS)
(3 more) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
13 |
A9X1D0 (/ISS)
B0VX69 (/ISS)
B0VX69 (/ISS)
B1MTJ4 (/ISS)
B2KI88 (/ISS)
B5FW36 (/ISS)
B7ZUF3 (/ISS)
C1FXW2 (/ISS)
E2RBS6 (/ISS)
Q5ZML9 (/ISS)
(3 more) |
|
Peptidyl-histidine methylation GO:0018021
The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine) or peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine).
|
11 |
A9X1D0 (/ISS)
B0VX69 (/ISS)
B0VX69 (/ISS)
B1MTJ4 (/ISS)
B2KI88 (/ISS)
B5FW36 (/ISS)
B7ZUF3 (/ISS)
C1FXW2 (/ISS)
E2RBS6 (/ISS)
Q5ZML9 (/ISS)
(1 more) |
|
Actin modification GO:0030047
Covalent modification of an actin molecule.
|
11 |
A9X1D0 (/ISS)
B0VX69 (/ISS)
B0VX69 (/ISS)
B1MTJ4 (/ISS)
B2KI88 (/ISS)
B5FW36 (/ISS)
B7ZUF3 (/ISS)
C1FXW2 (/ISS)
E2RBS6 (/ISS)
Q5ZML9 (/ISS)
(1 more) |
|
Regulation of uterine smooth muscle contraction GO:0070472
Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction.
|
11 |
A9X1D0 (/ISS)
B0VX69 (/ISS)
B0VX69 (/ISS)
B1MTJ4 (/ISS)
B2KI88 (/ISS)
B5FW36 (/ISS)
C1FXW2 (/ISS)
E2RBS6 (/ISS)
G3V6U9 (/ISS)
Q86TU7 (/ISS)
(1 more) |
|
Peptidyl-histidine methylation GO:0018021
The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine) or peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine).
|
3 | G3V6U9 (/IDA) Q86TU7 (/IDA) Q86TU7 (/IDA) |
|
Actin modification GO:0030047
Covalent modification of an actin molecule.
|
3 | G3V6U9 (/IDA) Q86TU7 (/IDA) Q86TU7 (/IDA) |
|
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
|
1 | Q7SXS7 (/TAS) |
|
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
1 | Q7SXS7 (/TAS) |
|
Histone H3-K36 methylation GO:0010452
The modification of histone H3 by addition of one or more methyl groups to lysine at position 36 of the histone.
|
1 | Q7SXS7 (/IDA) |
|
Peptidyl-histidine methylation GO:0018021
The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine) or peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine).
|
1 | Q91WC0 (/IMP) |
|
Peptidyl-histidine methylation GO:0018021
The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine) or peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine).
|
1 | Q91WC0 (/ISO) |
|
Peptidyl-lysine trimethylation GO:0018023
The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine.
|
1 | Q7SXS7 (/IDA) |
|
Peptidyl-lysine monomethylation GO:0018026
The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine.
|
1 | Q7SXS7 (/IDA) |
|
Peptidyl-lysine dimethylation GO:0018027
The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine.
|
1 | Q7SXS7 (/IDA) |
|
Actin modification GO:0030047
Covalent modification of an actin molecule.
|
1 | Q91WC0 (/IMP) |
|
Actin modification GO:0030047
Covalent modification of an actin molecule.
|
1 | Q91WC0 (/ISO) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q7SXS7 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q91WC0 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q91WC0 (/IGI) |
|
Positive regulation of muscle cell differentiation GO:0051149
Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.
|
1 | Q91WC0 (/IMP) |
|
Regulation of uterine smooth muscle contraction GO:0070472
Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction.
|
1 | Q91WC0 (/IMP) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
13 |
A9X1D0 (/ISS)
B0VX69 (/ISS)
B0VX69 (/ISS)
B1MTJ4 (/ISS)
B2KI88 (/ISS)
B5FW36 (/ISS)
B7ZUF3 (/ISS)
C1FXW2 (/ISS)
E2RBS6 (/ISS)
G3V6U9 (/ISS)
(3 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q86TU7 (/TAS) Q86TU7 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q86TU7 (/IDA) Q86TU7 (/IDA) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
1 | Q91WC0 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q91WC0 (/ISO) |
