The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Aspartate Aminotransferase, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 29: 5-aminolevulinate synthase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
5-aminolevulinate synthase activity GO:0003870
Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA.
11 O18680 (/ISS) P08680 (/ISS) P08680 (/ISS) Q3ZC31 (/ISS) Q54UX3 (/ISS) Q5R557 (/ISS) Q63147 (/ISS) Q8T4G6 (/ISS) Q9XT75 (/ISS) Q9XT75 (/ISS)
(1 more)
5-aminolevulinate synthase activity GO:0003870
Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA.
5 O14092 (/IMP) O94069 (/IMP) P08680 (/IMP) P08680 (/IMP) P09950 (/IMP)
5-aminolevulinate synthase activity GO:0003870
Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA.
4 P09950 (/IDA) P13195 (/IDA) P22557 (/IDA) Q63147 (/IDA)
5-aminolevulinate synthase activity GO:0003870
Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA.
4 P08680 (/ISO) P08680 (/ISO) Q8VC19 (/ISO) Q8VC19 (/ISO)
Glycine binding GO:0016594
Interacting selectively and non-covalently with glycine, aminoethanoic acid.
2 P08680 (/ISO) P08680 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q8VC19 (/ISO) Q8VC19 (/ISO)
Coenzyme binding GO:0050662
Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
2 P08680 (/ISO) P08680 (/ISO)
5-aminolevulinate synthase activity GO:0003870
Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA.
1 O94069 (/NAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P22557 (/IPI)
Transaminase activity GO:0008483
Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.
1 O14092 (/ISM)
Showing 1 to 10 of 14 entries

There are 41 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
8 P08680 (/ISS) P08680 (/ISS) Q3ZC31 (/ISS) Q5R557 (/ISS) Q63147 (/ISS) Q9XT75 (/ISS) Q9XT75 (/ISS) Q9YHT4 (/ISS)
Heme biosynthetic process GO:0006783
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
8 O18680 (/ISS) P22557 (/ISS) Q54UX3 (/ISS) Q63147 (/ISS) Q8T4G6 (/ISS) Q9XT75 (/ISS) Q9XT75 (/ISS) Q9YHT4 (/ISS)
Heme biosynthetic process GO:0006783
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
6 O14092 (/IMP) O94069 (/IMP) P08680 (/IMP) P08680 (/IMP) P09950 (/IMP) Q9YHT4 (/IMP)
Siroheme biosynthetic process GO:0019354
The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings.
6 A2R9H8 (/IMP) A2R9H8 (/IMP) A2R9H8 (/IMP) A2R9H8 (/IMP) A2R9H8 (/IMP) A2R9H8 (/IMP)
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
5 P22557 (/ISS) Q63147 (/ISS) Q9XT75 (/ISS) Q9XT75 (/ISS) Q9YHT4 (/ISS)
Hemoglobin biosynthetic process GO:0042541
The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
5 P22557 (/ISS) Q63147 (/ISS) Q9XT75 (/ISS) Q9XT75 (/ISS) Q9YHT4 (/ISS)
Hemoglobin biosynthetic process GO:0042541
The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
3 P08680 (/IMP) P08680 (/IMP) Q9YHT4 (/IMP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
2 P13195 (/IEP) Q63147 (/IEP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
2 P08680 (/ISO) P08680 (/ISO)
Heme biosynthetic process GO:0006783
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
2 P18080 (/TAS) P22557 (/TAS)
Showing 1 to 10 of 41 entries

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
8 P08680 (/ISS) P08680 (/ISS) Q3ZC31 (/ISS) Q5R557 (/ISS) Q63147 (/ISS) Q9XT75 (/ISS) Q9XT75 (/ISS) Q9YHT4 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
7 P08680 (/ISS) P08680 (/ISS) Q54UX3 (/ISS) Q63147 (/ISS) Q9XT75 (/ISS) Q9XT75 (/ISS) Q9YHT4 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
6 O14092 (/HDA) P08680 (/HDA) P08680 (/HDA) P09950 (/HDA) Q8VC19 (/HDA) Q8VC19 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 P08680 (/ISO) P08680 (/ISO) Q8VC19 (/ISO) Q8VC19 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 P13195 (/IDA) P22557 (/IDA) Q63147 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
3 O14092 (/ISS) O18680 (/ISS) Q8T4G6 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q8VC19 (/ISO) Q8VC19 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
2 P08680 (/ISO) P08680 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 P18080 (/TAS) P22557 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q8VC19 (/ISO) Q8VC19 (/ISO)
Showing 1 to 10 of 13 entries
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