The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Ribonuclease Inhibitor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Slit guidance ligand 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 30 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 O88279 (/IPI) O88279 (/IPI) O94813 (/IPI) O94813 (/IPI) Q9DE36 (/IPI) Q9DE36 (/IPI) Q9R1B9 (/IPI) Q9R1B9 (/IPI) Q9WVC1 (/IPI) Q9WVC1 (/IPI)
Roundabout binding GO:0048495
Interacting selectively and non-covalently with the Roundabout (ROBO) receptor, a transmembrane receptor.
10 O75093 (/IPI) O75093 (/IPI) O75094 (/IPI) O75094 (/IPI) O94813 (/IPI) O94813 (/IPI) P24014 (/IPI) P24014 (/IPI) Q80TR4 (/IPI) Q80TR4 (/IPI)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
6 Q80TR4 (/TAS) Q80TR4 (/TAS) Q9R1B9 (/TAS) Q9R1B9 (/TAS) Q9WVB4 (/TAS) Q9WVB4 (/TAS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
6 O75093 (/NAS) O75093 (/NAS) O75094 (/NAS) O75094 (/NAS) O94813 (/NAS) O94813 (/NAS)
Roundabout binding GO:0048495
Interacting selectively and non-covalently with the Roundabout (ROBO) receptor, a transmembrane receptor.
6 Q80TR4 (/ISO) Q80TR4 (/ISO) Q9R1B9 (/ISO) Q9R1B9 (/ISO) Q9WVB4 (/ISO) Q9WVB4 (/ISO)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
4 O94813 (/IDA) O94813 (/IDA) P24014 (/IDA) P24014 (/IDA)
Heparan sulfate proteoglycan binding GO:0043395
Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit.
4 O88279 (/IDA) O88279 (/IDA) Q9WVC1 (/IDA) Q9WVC1 (/IDA)
Heparan sulfate proteoglycan binding GO:0043395
Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit.
4 Q80TR4 (/ISO) Q80TR4 (/ISO) Q9R1B9 (/ISO) Q9R1B9 (/ISO)
GTPase inhibitor activity GO:0005095
Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate.
2 O94813 (/IDA) O94813 (/IDA)
GTPase inhibitor activity GO:0005095
Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate.
2 Q9R1B9 (/ISO) Q9R1B9 (/ISO)
Showing 1 to 10 of 30 entries

There are 205 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Central nervous system projection neuron axonogenesis GO:0021952
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.
20 A0A0R4IFT2 (/IGI) A0A0R4IFT2 (/IGI) A0A2R8Q7E7 (/IGI) A0A2R8Q7E7 (/IGI) A0A2R8RID6 (/IGI) A0A2R8RID6 (/IGI) A0A2R8RWP7 (/IGI) A0A2R8RWP7 (/IGI) A0A2R8RXU4 (/IGI) A0A2R8RXU4 (/IGI)
(10 more)
Central nervous system projection neuron axonogenesis GO:0021952
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.
20 A0A0R4IFT2 (/IMP) A0A0R4IFT2 (/IMP) A0A2R8Q7E7 (/IMP) A0A2R8Q7E7 (/IMP) A0A2R8RID6 (/IMP) A0A2R8RID6 (/IMP) A0A2R8RWP7 (/IMP) A0A2R8RWP7 (/IMP) A0A2R8RXU4 (/IMP) A0A2R8RXU4 (/IMP)
(10 more)
Negative regulation of axon extension GO:0030517
Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.
20 A0A0R4IFT2 (/IGI) A0A0R4IFT2 (/IGI) A0A2R8Q7E7 (/IGI) A0A2R8Q7E7 (/IGI) A0A2R8RID6 (/IGI) A0A2R8RID6 (/IGI) A0A2R8RWP7 (/IGI) A0A2R8RWP7 (/IGI) A0A2R8RXU4 (/IGI) A0A2R8RXU4 (/IGI)
(10 more)
Negative regulation of axon extension GO:0030517
Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.
20 A0A0R4IFT2 (/IMP) A0A0R4IFT2 (/IMP) A0A2R8Q7E7 (/IMP) A0A2R8Q7E7 (/IMP) A0A2R8RID6 (/IMP) A0A2R8RID6 (/IMP) A0A2R8RWP7 (/IMP) A0A2R8RWP7 (/IMP) A0A2R8RXU4 (/IMP) A0A2R8RXU4 (/IMP)
(10 more)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
18 A0A0R4IAZ7 (/NAS) A0A0R4IAZ7 (/NAS) A0A0R4IU60 (/NAS) A0A0R4IU60 (/NAS) A0A2R8QDY6 (/NAS) A0A2R8QDY6 (/NAS) B0CM06 (/NAS) B0CM06 (/NAS) B3DJM7 (/NAS) B3DJM7 (/NAS)
(8 more)
Cranial nerve morphogenesis GO:0021602
The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.
18 A0A0R4IAZ7 (/IMP) A0A0R4IAZ7 (/IMP) A0A0R4IU60 (/IMP) A0A0R4IU60 (/IMP) A0A2R8QDY6 (/IMP) A0A2R8QDY6 (/IMP) B0CM06 (/IMP) B0CM06 (/IMP) B3DJM7 (/IMP) B3DJM7 (/IMP)
(8 more)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
16 A0A0R4IFT2 (/IMP) A0A0R4IFT2 (/IMP) A0A2R8RID6 (/IMP) A0A2R8RID6 (/IMP) A0A2R8RWP7 (/IMP) A0A2R8RWP7 (/IMP) A0A2R8RXU4 (/IMP) A0A2R8RXU4 (/IMP) F1QQE4 (/IMP) F1QQE4 (/IMP)
(6 more)
Morphogenesis of a branching structure GO:0001763
The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.
12 A0A0R4IFT2 (/IMP) A0A0R4IFT2 (/IMP) A0A2R8RID6 (/IMP) A0A2R8RID6 (/IMP) A0A2R8RWP7 (/IMP) A0A2R8RWP7 (/IMP) A0A2R8RXU4 (/IMP) A0A2R8RXU4 (/IMP) F1QQE4 (/IMP) F1QQE4 (/IMP)
(2 more)
Endocardial progenitor cell migration to the midline involved in heart field formation GO:0003262
The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart.
12 A0A0R4IFT2 (/IGI) A0A0R4IFT2 (/IGI) A0A2R8RID6 (/IGI) A0A2R8RID6 (/IGI) A0A2R8RWP7 (/IGI) A0A2R8RWP7 (/IGI) A0A2R8RXU4 (/IGI) A0A2R8RXU4 (/IGI) F1QQE4 (/IGI) F1QQE4 (/IGI)
(2 more)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
12 O75093 (/IDA) O75093 (/IDA) O75094 (/IDA) O75094 (/IDA) O94813 (/IDA) O94813 (/IDA) Q80TR4 (/IDA) Q80TR4 (/IDA) Q9R1B9 (/IDA) Q9R1B9 (/IDA)
(2 more)
Showing 1 to 10 of 205 entries

There are 23 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
12 O75094 (/IDA) O75094 (/IDA) O88279 (/IDA) O88279 (/IDA) O94813 (/IDA) O94813 (/IDA) Q80TR4 (/IDA) Q80TR4 (/IDA) Q9R1B9 (/IDA) Q9R1B9 (/IDA)
(2 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
12 O94813 (/TAS) O94813 (/TAS) P24014 (/TAS) P24014 (/TAS) Q3S2J2 (/TAS) Q3S2J2 (/TAS) Q80TR4 (/TAS) Q80TR4 (/TAS) Q9R1B9 (/TAS) Q9R1B9 (/TAS)
(2 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
6 Q80TR4 (/ISO) Q80TR4 (/ISO) Q9R1B9 (/ISO) Q9R1B9 (/ISO) Q9WVB4 (/ISO) Q9WVB4 (/ISO)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
6 D2XV92 (/IDA) D2XV92 (/IDA) F1NF14 (/IDA) F1NF14 (/IDA) Q90XG4 (/IDA) Q90Z44 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
4 Q9R1B9 (/HDA) Q9R1B9 (/HDA) Q9WVB4 (/HDA) Q9WVB4 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P24014 (/IDA) P24014 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 G5EFX6 (/ISS) G5EFX6 (/ISS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 O94813 (/TAS) O94813 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 O75093 (/NAS) O75093 (/NAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 O94813 (/IDA) O94813 (/IDA)
Showing 1 to 10 of 23 entries
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