The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Ribonuclease Inhibitor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 195: Toll-like receptor 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Lipopolysaccharide receptor activity GO:0001875
Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
17 P58727 (/ISS) Q2V898 (/ISS) Q68Y56 (/ISS) Q68Y56 (/ISS) Q8SPE8 (/ISS) Q8SPE9 (/ISS) Q9GL65 (/ISS) Q9MYW3 (/ISS) Q9QUK6 (/ISS) Q9QUK6 (/ISS)
(7 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 O00206 (/IPI) Q9QUK6 (/IPI) Q9QUK6 (/IPI) Q9QX05 (/IPI)
Lipopolysaccharide binding GO:0001530
Interacting selectively and non-covalently with lipopolysaccharide.
2 Q9QUK6 (/ISO) Q9QUK6 (/ISO)
Lipopolysaccharide receptor activity GO:0001875
Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
2 Q9QUK6 (/ISO) Q9QUK6 (/ISO)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2 Q9QUK6 (/ISO) Q9QUK6 (/ISO)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
2 O00206 (/TAS) Q9QX05 (/TAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q9QUK6 (/ISO) Q9QUK6 (/ISO)
Phosphatidylinositol 3-kinase binding GO:0043548
Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
2 Q9QUK6 (/ISO) Q9QUK6 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 Q9QUK6 (/ISO) Q9QUK6 (/ISO)
Lipopolysaccharide binding GO:0001530
Interacting selectively and non-covalently with lipopolysaccharide.
1 Q9QX05 (/IDA)
Showing 1 to 10 of 19 entries

There are 209 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Interleukin-1 beta secretion GO:0050702
The regulated release of interleukin 1 beta from a cell.
16 O00206 (/ISS) P58727 (/ISS) Q2V898 (/ISS) Q68Y56 (/ISS) Q68Y56 (/ISS) Q8SPE8 (/ISS) Q8SPE9 (/ISS) Q9GL65 (/ISS) Q9MYW3 (/ISS) Q9QX05 (/ISS)
(6 more)
Positive regulation of NLRP3 inflammasome complex assembly GO:1900227
Any process that activates or increases the frequency, rate or extent of NLRP3 inflammasome complex assembly.
16 O00206 (/ISS) P58727 (/ISS) Q2V898 (/ISS) Q68Y56 (/ISS) Q68Y56 (/ISS) Q8SPE8 (/ISS) Q8SPE9 (/ISS) Q9GL65 (/ISS) Q9MYW3 (/ISS) Q9QX05 (/ISS)
(6 more)
Detection of lipopolysaccharide GO:0032497
The series of events in which a lipopolysaccharide stimulus is received by a cell and converted into a molecular signal. Lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
15 P58727 (/ISS) Q2V898 (/ISS) Q68Y56 (/ISS) Q68Y56 (/ISS) Q8SPE8 (/ISS) Q8SPE9 (/ISS) Q9GL65 (/ISS) Q9MYW3 (/ISS) Q9QX05 (/ISS) Q9TSP2 (/ISS)
(5 more)
Macrophage activation GO:0042116
A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
12 P58727 (/ISS) Q8SPE8 (/ISS) Q8SPE9 (/ISS) Q8SQ55 (/ISS) Q9GL65 (/ISS) Q9MYW3 (/ISS) Q9QUK6 (/ISS) Q9QUK6 (/ISS) Q9TSP2 (/ISS) Q9TTN0 (/ISS)
(2 more)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
3 O00206 (/IMP) Q9QUK6 (/IMP) Q9QUK6 (/IMP)
Lipopolysaccharide-mediated signaling pathway GO:0031663
A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
3 O00206 (/IGI) Q9QUK6 (/IGI) Q9QUK6 (/IGI)
Positive regulation of chemokine production GO:0032722
Any process that activates or increases the frequency, rate, or extent of chemokine production.
3 O00206 (/IDA) Q9QUK6 (/IDA) Q9QUK6 (/IDA)
Positive regulation of interleukin-6 production GO:0032755
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
3 O00206 (/IDA) Q9QUK6 (/IDA) Q9QUK6 (/IDA)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
3 O00206 (/TAS) Q9QUK6 (/TAS) Q9QUK6 (/TAS)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
3 O00206 (/IDA) Q9QUK6 (/IDA) Q9QUK6 (/IDA)
Showing 1 to 10 of 209 entries

There are 26 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Lipopolysaccharide receptor complex GO:0046696
A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated and which functions as a lipopolysaccharide (LPS) receptor that primes the innate immune response against bacterial pathogens.
17 P58727 (/ISS) Q2V898 (/ISS) Q68Y56 (/ISS) Q68Y56 (/ISS) Q8SPE8 (/ISS) Q8SPE9 (/ISS) Q9GL65 (/ISS) Q9MYW3 (/ISS) Q9QUK6 (/ISS) Q9QUK6 (/ISS)
(7 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 O00206 (/IDA) Q9QUK6 (/IDA) Q9QUK6 (/IDA)
Phagocytic cup GO:0001891
An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.
2 Q9QUK6 (/ISO) Q9QUK6 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 O00206 (/IDA) Q9QX05 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q9QUK6 (/ISO) Q9QUK6 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q9QUK6 (/ISO) Q9QUK6 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q9QUK6 (/ISO) Q9QUK6 (/ISO)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
2 Q9QUK6 (/ISO) Q9QUK6 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 O00206 (/IDA) Q9QX05 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 Q9QUK6 (/ISO) Q9QUK6 (/ISO)
Showing 1 to 10 of 26 entries
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