The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Glutamate synthase, large subunit

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutamate synthase (NADPH) activity GO:0004355
Catalysis of the reaction: 2 L-glutamate + NADP(+) = 2-oxoglutarate + L-glutamine + H(+) + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+.
19 Q48PG8 (/ISS) Q48PG8 (/ISS) Q48PG8 (/ISS) Q48PG8 (/ISS) Q48PG8 (/ISS) Q48PG8 (/ISS) Q48PG8 (/ISS) Q48PG8 (/ISS) Q48PG8 (/ISS) Q87V18 (/ISS)
(9 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
14 P09831 (/IPI) P09831 (/IPI) P09831 (/IPI) P09831 (/IPI) P09831 (/IPI) P09831 (/IPI) P09831 (/IPI) P55037 (/IPI) P96218 (/IPI) P96218 (/IPI)
(4 more)
Glutamate synthase (NADPH) activity GO:0004355
Catalysis of the reaction: 2 L-glutamate + NADP(+) = 2-oxoglutarate + L-glutamine + H(+) + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+.
7 P09831 (/IDA) P09831 (/IDA) P09831 (/IDA) P09831 (/IDA) P09831 (/IDA) P09831 (/IDA) P09831 (/IDA)
Glutamate synthase activity GO:0015930
Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors.
7 Q606H7 (/ISS) Q8EHA4 (/ISS) Q9KPJ4 (/ISS) Q9KPJ4 (/ISS) Q9KPJ4 (/ISS) Q9KPJ4 (/ISS) Q9KPJ4 (/ISS)
Glutamate synthase (NADH) activity GO:0016040
Catalysis of the reaction: 2 L-glutamate + NAD(+) = 2-oxoglutarate + L-glutamine + H(+) + NADH.
4 Q12680 (/IDA) Q12680 (/IDA) Q12680 (/IDA) Q9C102 (/IDA)
Glutamate synthase (NADH) activity GO:0016040
Catalysis of the reaction: 2 L-glutamate + NAD(+) = 2-oxoglutarate + L-glutamine + H(+) + NADH.
4 C8VEZ6 (/IMP) Q12680 (/IMP) Q12680 (/IMP) Q12680 (/IMP)
Glutamate synthase (ferredoxin) activity GO:0016041
Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + 2 oxidized ferredoxin + H2O = NH3 + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+.
3 Q43155 (/IDA) Q9ZNZ7 (/IDA) Q9ZNZ7 (/IDA)
Glutamate synthase (ferredoxin) activity GO:0016041
Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + 2 oxidized ferredoxin + H2O = NH3 + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+.
3 Q9T0P4 (/ISS) Q9ZNZ7 (/ISS) Q9ZNZ7 (/ISS)
Glutamate synthase (NADH) activity GO:0016040
Catalysis of the reaction: 2 L-glutamate + NAD(+) = 2-oxoglutarate + L-glutamine + H(+) + NADH.
1 C8VEZ6 (/ISA)
Glutamate synthase (NADH) activity GO:0016040
Catalysis of the reaction: 2 L-glutamate + NAD(+) = 2-oxoglutarate + L-glutamine + H(+) + NADH.
1 C8VEZ6 (/RCA)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q43155 (/IPI)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutamate biosynthetic process GO:0006537
The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.
27 Q48PG8 (/ISS) Q48PG8 (/ISS) Q48PG8 (/ISS) Q48PG8 (/ISS) Q48PG8 (/ISS) Q48PG8 (/ISS) Q48PG8 (/ISS) Q48PG8 (/ISS) Q48PG8 (/ISS) Q5LLZ6 (/ISS)
(17 more)
Glutamate biosynthetic process GO:0006537
The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.
7 P09831 (/IDA) P09831 (/IDA) P09831 (/IDA) P09831 (/IDA) P09831 (/IDA) P09831 (/IDA) P09831 (/IDA)
Glutamate biosynthetic process GO:0006537
The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.
3 Q12680 (/IEP) Q12680 (/IEP) Q12680 (/IEP)
Ammonia assimilation cycle GO:0019676
The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen.
3 Q12680 (/IEP) Q12680 (/IEP) Q12680 (/IEP)
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
2 Q9ZNZ7 (/IEP) Q9ZNZ7 (/IEP)
Response to sucrose GO:0009744
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus.
2 Q9ZNZ7 (/IEP) Q9ZNZ7 (/IEP)
Photorespiration GO:0009853
A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria.
2 Q9ZNZ7 (/IMP) Q9ZNZ7 (/IMP)
Photorespiration GO:0009853
A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria.
2 Q9ZNZ7 (/TAS) Q9ZNZ7 (/TAS)
Positive regulation of glycine hydroxymethyltransferase activity GO:0080114
Any process that activates or increases the frequency, rate or extent of glycine hydroxymethyltransferase activity, the catalysis of the reaction 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.
2 Q9ZNZ7 (/IDA) Q9ZNZ7 (/IDA)
Glutamine family amino acid metabolic process GO:0009064
The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.
1 C8VEZ6 (/IGI)
Glutamine family amino acid metabolic process GO:0009064
The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.
1 C8VEZ6 (/IMP)
Glutamine family amino acid metabolic process GO:0009064
The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.
1 C8VEZ6 (/RCA)
Ammonia assimilation cycle GO:0019676
The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen.
1 Q9C102 (/EXP)
Ammonia assimilation cycle GO:0019676
The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen.
1 Q9C102 (/IMP)
Invasive filamentous growth GO:0036267
The growth of colonies in filamentous chains of cells into a substrate.
1 Q9C102 (/IMP)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 Q43155 (/IDA)
L-glutamate biosynthetic process GO:0097054
The chemical reactions and pathways resulting in the formation of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid.
1 Q9C102 (/EXP)
L-glutamate biosynthetic process GO:0097054
The chemical reactions and pathways resulting in the formation of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid.
1 Q9C102 (/IDA)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 P09831 (/IDA) P09831 (/IDA) P09831 (/IDA) P09831 (/IDA) P09831 (/IDA) P09831 (/IDA) P09831 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P96218 (/HDA) P96218 (/HDA) P96218 (/HDA) P96218 (/HDA) Q9C102 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P96218 (/HDA) P96218 (/HDA) P96218 (/HDA) P96218 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 Q12680 (/HDA) Q12680 (/HDA) Q12680 (/HDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
3 Q9T0P4 (/IDA) Q9ZNZ7 (/IDA) Q9ZNZ7 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
3 Q43155 (/IDA) Q9ZNZ7 (/IDA) Q9ZNZ7 (/IDA)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
3 Q9T0P4 (/IDA) Q9ZNZ7 (/IDA) Q9ZNZ7 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q9ZNZ7 (/IDA) Q9ZNZ7 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q9ZNZ7 (/IDA) Q9ZNZ7 (/IDA)
Apoplast GO:0048046
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
2 Q9ZNZ7 (/IDA) Q9ZNZ7 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9C102 (/ISO)
Plastid GO:0009536
Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
1 Q9T0P4 (/IDA)
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