The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Iron/manganese superoxide dismutase, C-terminal domain
".
FunFam 1: Superoxide dismutase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 12 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Superoxide dismutase activity GO:0004784
Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.
|
187 |
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
(177 more) |
Superoxide dismutase activity GO:0004784
Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.
|
175 |
Q48EJ8 (/ISS)
Q48EJ8 (/ISS)
Q48EJ8 (/ISS)
Q48EJ8 (/ISS)
Q48EJ8 (/ISS)
Q48EJ8 (/ISS)
Q48EJ8 (/ISS)
Q48EJ8 (/ISS)
Q48EJ8 (/ISS)
Q48EJ8 (/ISS)
(165 more) |
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
|
160 |
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
(150 more) |
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
|
160 |
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
(150 more) |
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
|
26 |
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
(16 more) |
Superoxide dismutase activity GO:0004784
Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.
|
20 |
Q8IAY6 (/ISO)
Q8IAY6 (/ISO)
Q8IAY6 (/ISO)
Q8IAY6 (/ISO)
Q8IAY6 (/ISO)
Q8IAY6 (/ISO)
Q8IAY6 (/ISO)
Q8IAY6 (/ISO)
Q8IAY6 (/ISO)
Q8IAY6 (/ISO)
(10 more) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
20 |
Q8IAY6 (/IPI)
Q8IAY6 (/IPI)
Q8IAY6 (/IPI)
Q8IAY6 (/IPI)
Q8IAY6 (/IPI)
Q8IAY6 (/IPI)
Q8IAY6 (/IPI)
Q8IAY6 (/IPI)
Q8IAY6 (/IPI)
Q8IAY6 (/IPI)
(10 more) |
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
15 |
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
(5 more) |
Antioxidant activity GO:0016209
Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
|
15 |
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
(5 more) |
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
|
15 |
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
(5 more) |
Superoxide dismutase activity GO:0004784
Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.
|
6 | Q381J5 (/ISM) Q381J5 (/ISM) Q381J5 (/ISM) Q381T3 (/ISM) Q381T3 (/ISM) Q967T0 (/ISM) |
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
|
6 | Q381J5 (/ISM) Q381J5 (/ISM) Q381J5 (/ISM) Q381T3 (/ISM) Q381T3 (/ISM) Q967T0 (/ISM) |
There are 14 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Removal of superoxide radicals GO:0019430
Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2).
|
186 |
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
(176 more) |
Superoxide metabolic process GO:0006801
The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.
|
175 |
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
(165 more) |
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
|
175 |
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
(165 more) |
Removal of superoxide radicals GO:0019430
Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2).
|
172 |
Q48EJ8 (/ISS)
Q48EJ8 (/ISS)
Q48EJ8 (/ISS)
Q48EJ8 (/ISS)
Q48EJ8 (/ISS)
Q48EJ8 (/ISS)
Q48EJ8 (/ISS)
Q48EJ8 (/ISS)
Q48EJ8 (/ISS)
Q48EJ8 (/ISS)
(162 more) |
Response to superoxide GO:0000303
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion.
|
160 |
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
P0AGD3 (/IDA)
(150 more) |
Response to superoxide GO:0000303
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion.
|
160 |
P0AGD3 (/IMP)
P0AGD3 (/IMP)
P0AGD3 (/IMP)
P0AGD3 (/IMP)
P0AGD3 (/IMP)
P0AGD3 (/IMP)
P0AGD3 (/IMP)
P0AGD3 (/IMP)
P0AGD3 (/IMP)
P0AGD3 (/IMP)
(150 more) |
Superoxide metabolic process GO:0006801
The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.
|
160 |
P0AGD3 (/IMP)
P0AGD3 (/IMP)
P0AGD3 (/IMP)
P0AGD3 (/IMP)
P0AGD3 (/IMP)
P0AGD3 (/IMP)
P0AGD3 (/IMP)
P0AGD3 (/IMP)
P0AGD3 (/IMP)
P0AGD3 (/IMP)
(150 more) |
Superoxide metabolic process GO:0006801
The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.
|
20 |
Q8IAY6 (/ISS)
Q8IAY6 (/ISS)
Q8IAY6 (/ISS)
Q8IAY6 (/ISS)
Q8IAY6 (/ISS)
Q8IAY6 (/ISS)
Q8IAY6 (/ISS)
Q8IAY6 (/ISS)
Q8IAY6 (/ISS)
Q8IAY6 (/ISS)
(10 more) |
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
20 |
Q8IAY6 (/ISS)
Q8IAY6 (/ISS)
Q8IAY6 (/ISS)
Q8IAY6 (/ISS)
Q8IAY6 (/ISS)
Q8IAY6 (/ISS)
Q8IAY6 (/ISS)
Q8IAY6 (/ISS)
Q8IAY6 (/ISS)
Q8IAY6 (/ISS)
(10 more) |
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
15 |
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
(5 more) |
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
15 |
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
(5 more) |
Response to acidic pH GO:0010447
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
|
15 |
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
P00448 (/IMP)
(5 more) |
Cellular response to selenium ion GO:0071291
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion.
|
15 |
P00448 (/IEP)
P00448 (/IEP)
P00448 (/IEP)
P00448 (/IEP)
P00448 (/IEP)
P00448 (/IEP)
P00448 (/IEP)
P00448 (/IEP)
P00448 (/IEP)
P00448 (/IEP)
(5 more) |
Superoxide metabolic process GO:0006801
The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.
|
6 | Q381J5 (/ISM) Q381J5 (/ISM) Q381J5 (/ISM) Q381T3 (/ISM) Q381T3 (/ISM) Q967T0 (/ISM) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
179 |
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
(169 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
160 |
P0AGD3 (/HDA)
P0AGD3 (/HDA)
P0AGD3 (/HDA)
P0AGD3 (/HDA)
P0AGD3 (/HDA)
P0AGD3 (/HDA)
P0AGD3 (/HDA)
P0AGD3 (/HDA)
P0AGD3 (/HDA)
P0AGD3 (/HDA)
(150 more) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
160 |
P0AGD3 (/HDA)
P0AGD3 (/HDA)
P0AGD3 (/HDA)
P0AGD3 (/HDA)
P0AGD3 (/HDA)
P0AGD3 (/HDA)
P0AGD3 (/HDA)
P0AGD3 (/HDA)
P0AGD3 (/HDA)
P0AGD3 (/HDA)
(150 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
41 |
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
P00448 (/IDA)
(31 more) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
6 | Q381J5 (/IDA) Q381J5 (/IDA) Q381J5 (/IDA) Q381T3 (/IDA) Q381T3 (/IDA) Q967T0 (/IDA) |
Glycosome GO:0020015
A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis.
|
6 | Q381J5 (/IDA) Q381J5 (/IDA) Q381J5 (/IDA) Q381T3 (/IDA) Q381T3 (/IDA) Q967T0 (/IDA) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q4Q596 (/ISO) Q4Q597 (/ISO) |