The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
GroEL
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: T-complex protein 1 subunit theta

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
21 O96220 (/IPI) O96220 (/IPI) O96220 (/IPI) O96220 (/IPI) O96220 (/IPI) O96220 (/IPI) O96220 (/IPI) O96220 (/IPI) O96220 (/IPI) O96220 (/IPI)
(11 more)
ATPase activity, coupled GO:0042623
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.
4 P50990 (/TAS) P50990 (/TAS) P50990 (/TAS) P50990 (/TAS)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
4 P50990 (/HDA) P50990 (/HDA) P50990 (/HDA) P50990 (/HDA)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
4 P47079 (/IDA) P47079 (/IDA) P47079 (/IDA) P47079 (/IDA)
Protein folding chaperone GO:0044183
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) that contributes to the process of protein folding.
2 Q94K05 (/IDA) Q94K05 (/IDA)
Protein folding chaperone GO:0044183
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) that contributes to the process of protein folding.
2 Q94K05 (/IPI) Q94K05 (/IPI)
Anion channel activity GO:0005253
Enables the energy-independent passage of anions across a lipid bilayer down a concentration gradient.
1 Q96SF2 (/TAS)
Calcium-activated potassium channel activity GO:0015269
Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient.
1 Q96SF2 (/TAS)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
1 Q38AE5 (/ISA)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
1 P78921 (/ISO)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
1 Q552J0 (/ISS)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
6 P50990 (/TAS) P50990 (/TAS) P50990 (/TAS) P50990 (/TAS) Q94K05 (/TAS) Q94K05 (/TAS)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
4 P47079 (/IDA) P47079 (/IDA) P47079 (/IDA) P47079 (/IDA)
Positive regulation of telomere maintenance via telomerase GO:0032212
Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.
4 P50990 (/IMP) P50990 (/IMP) P50990 (/IMP) P50990 (/IMP)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
4 P50990 (/TAS) P50990 (/TAS) P50990 (/TAS) P50990 (/TAS)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
4 P50990 (/IMP) P50990 (/IMP) P50990 (/IMP) P50990 (/IMP)
Positive regulation of establishment of protein localization to telomere GO:1904851
Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere.
4 P50990 (/IMP) P50990 (/IMP) P50990 (/IMP) P50990 (/IMP)
Positive regulation of protein localization to Cajal body GO:1904871
Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body.
4 P50990 (/HMP) P50990 (/HMP) P50990 (/HMP) P50990 (/HMP)
Positive regulation of telomerase RNA localization to Cajal body GO:1904874
Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body.
4 P50990 (/HMP) P50990 (/HMP) P50990 (/HMP) P50990 (/HMP)
Behavioral response to nicotine GO:0035095
Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus.
3 A0A0R4IJT8 (/IMP) Q6TNV4 (/IMP) Q7ZU96 (/IMP)
Binding of sperm to zona pellucida GO:0007339
The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place.
2 P42932 (/IDA) P42932 (/IDA)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
2 Q5AB74 (/IMP) Q5AB74 (/IMP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
2 Q5AB74 (/IMP) Q5AB74 (/IMP)
Positive regulation of telomere maintenance via telomerase GO:0032212
Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.
2 P42932 (/ISO) P42932 (/ISO)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
2 Q5AB74 (/IMP) Q5AB74 (/IMP)
Filamentous growth of a population of unicellular organisms in response to starvation GO:0036170
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
2 Q5AB74 (/IMP) Q5AB74 (/IMP)
Filamentous growth of a population of unicellular organisms in response to chemical stimulus GO:0036171
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a chemical stimulus.
2 Q5AB74 (/IMP) Q5AB74 (/IMP)
Filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0036180
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
2 Q5AB74 (/IMP) Q5AB74 (/IMP)
Pore complex assembly GO:0046931
The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases.
2 P42932 (/IMP) P42932 (/IMP)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
2 P42932 (/ISO) P42932 (/ISO)
Positive regulation of transport GO:0051050
Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q94K05 (/IMP) Q94K05 (/IMP)
Cellular response to N-acetyl-D-glucosamine GO:0097316
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an N-acetyl-D-glucosamine stimulus.
2 Q5AB74 (/IMP) Q5AB74 (/IMP)
Toxin transport GO:1901998
The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P42932 (/IMP) P42932 (/IMP)
Positive regulation of establishment of protein localization to telomere GO:1904851
Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere.
2 P42932 (/ISO) P42932 (/ISO)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
1 Q38AE5 (/ISA)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
1 P78921 (/ISO)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
1 Q552J0 (/ISS)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 Q38AE5 (/ISA)

There are 34 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chaperonin-containing T-complex GO:0005832
A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.
26 O96220 (/IDA) O96220 (/IDA) O96220 (/IDA) O96220 (/IDA) O96220 (/IDA) O96220 (/IDA) O96220 (/IDA) O96220 (/IDA) O96220 (/IDA) O96220 (/IDA)
(16 more)
Host cell cytoplasm GO:0030430
The cytoplasm of a host cell.
13 O96220 (/IDA) O96220 (/IDA) O96220 (/IDA) O96220 (/IDA) O96220 (/IDA) O96220 (/IDA) O96220 (/IDA) O96220 (/IDA) O96220 (/IDA) O96220 (/IDA)
(3 more)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
13 O96220 (/IDA) O96220 (/IDA) O96220 (/IDA) O96220 (/IDA) O96220 (/IDA) O96220 (/IDA) O96220 (/IDA) O96220 (/IDA) O96220 (/IDA) O96220 (/IDA)
(3 more)
Chaperonin-containing T-complex GO:0005832
A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.
12 Q4R5J0 (/ISS) Q4R5J0 (/ISS) Q4R5J0 (/ISS) Q4R5J0 (/ISS) Q4R5J0 (/ISS) Q4R5J0 (/ISS) Q4R5J0 (/ISS) Q552J0 (/ISS) Q5RAP1 (/ISS) Q5RAP1 (/ISS)
(2 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 P50990 (/IDA) P50990 (/IDA) P50990 (/IDA) P50990 (/IDA) Q38AE5 (/IDA) Q94K05 (/IDA) Q94K05 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 H7C4C8 (/IDA) P50990 (/IDA) P50990 (/IDA) P50990 (/IDA) P50990 (/IDA) Q94K05 (/IDA) Q94K05 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 H7C4C8 (/IDA) P50990 (/IDA) P50990 (/IDA) P50990 (/IDA) P50990 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P50990 (/HDA) P50990 (/HDA) P50990 (/HDA) P50990 (/HDA) P78921 (/HDA)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
5 H7C4C8 (/IDA) P50990 (/IDA) P50990 (/IDA) P50990 (/IDA) P50990 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
4 P50990 (/TAS) P50990 (/TAS) P50990 (/TAS) P50990 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 P47079 (/HDA) P47079 (/HDA) P47079 (/HDA) P47079 (/HDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
4 P50990 (/IDA) P50990 (/IDA) P50990 (/IDA) P50990 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 P50990 (/TAS) P50990 (/TAS) P50990 (/TAS) P50990 (/TAS)
Chaperonin-containing T-complex GO:0005832
A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.
4 P47079 (/IPI) P47079 (/IPI) P47079 (/IPI) P47079 (/IPI)
Chaperonin-containing T-complex GO:0005832
A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.
4 P50990 (/TAS) P50990 (/TAS) P50990 (/TAS) P50990 (/TAS)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
4 P50990 (/IDA) P50990 (/IDA) P50990 (/IDA) P50990 (/IDA)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
4 P50990 (/TAS) P50990 (/TAS) P50990 (/TAS) P50990 (/TAS)
Azurophil granule lumen GO:0035578
The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
4 P50990 (/TAS) P50990 (/TAS) P50990 (/TAS) P50990 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
4 P50990 (/HDA) P50990 (/HDA) P50990 (/HDA) P50990 (/HDA)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
4 P50990 (/TAS) P50990 (/TAS) P50990 (/TAS) P50990 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P42932 (/ISO) P42932 (/ISO) Q4Q063 (/ISO)
Zona pellucida receptor complex GO:0002199
A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction.
2 P42932 (/IDA) P42932 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 P42932 (/ISO) P42932 (/ISO)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
2 P42932 (/ISO) P42932 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P42932 (/ISO) P42932 (/ISO)
Chaperonin-containing T-complex GO:0005832
A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.
2 P42932 (/ISO) P42932 (/ISO)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
2 P42932 (/ISO) P42932 (/ISO)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
2 Q94K05 (/IDA) Q94K05 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q94K05 (/IDA) Q94K05 (/IDA)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
2 P42932 (/IDA) P42932 (/IDA)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
2 P42932 (/ISO) P42932 (/ISO)
Chaperonin-containing T-complex GO:0005832
A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.
1 Q38AE5 (/ISA)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
1 P78921 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q7K3J0 (/HDA)
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