The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Histone deacetylase domain
".
FunFam 9: Histone deacetylase 11
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
8 | Q91WA3 (/TAS) Q91WA3 (/TAS) Q96DB2 (/TAS) Q96DB2 (/TAS) Q96DB2 (/TAS) Q9GKU5 (/TAS) Q9GKU5 (/TAS) Q9GKU5 (/TAS) |
|
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
|
5 | Q91WA3 (/TAS) Q91WA3 (/TAS) Q9GKU5 (/TAS) Q9GKU5 (/TAS) Q9GKU5 (/TAS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | Q91WA3 (/IPI) Q91WA3 (/IPI) Q96DB2 (/IPI) Q96DB2 (/IPI) Q96DB2 (/IPI) |
|
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
|
3 | Q96DB2 (/IDA) Q96DB2 (/IDA) Q96DB2 (/IDA) |
|
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
|
2 | Q91WA3 (/ISO) Q91WA3 (/ISO) |
|
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
|
1 | Q7MMB6 (/IDA) |
|
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
|
1 | Q7MMB6 (/IPI) |
|
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
|
1 | Q7MMB6 (/IDA) |
|
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
|
1 | Q7MMB6 (/IPI) |
|
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
|
1 | Q9VC26 (/ISS) |
|
Protein deacetylase activity GO:0033558
Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate.
|
1 | Q18477 (/ISS) |
There are 7 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
|
8 | Q91WA3 (/TAS) Q91WA3 (/TAS) Q96DB2 (/TAS) Q96DB2 (/TAS) Q96DB2 (/TAS) Q9GKU5 (/TAS) Q9GKU5 (/TAS) Q9GKU5 (/TAS) |
|
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
|
3 | Q96DB2 (/IDA) Q96DB2 (/IDA) Q96DB2 (/IDA) |
|
Oligodendrocyte development GO:0014003
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
|
2 | Q91WA3 (/ISO) Q91WA3 (/ISO) |
|
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
|
2 | Q91WA3 (/ISO) Q91WA3 (/ISO) |
|
Oligodendrocyte development GO:0014003
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
|
1 | B2GUW3 (/IMP) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q7MMB6 (/EXP) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q7MMB6 (/IEP) |
There are 11 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Histone deacetylase complex GO:0000118
A protein complex that possesses histone deacetylase activity.
|
5 | Q91WA3 (/TAS) Q91WA3 (/TAS) Q9GKU5 (/TAS) Q9GKU5 (/TAS) Q9GKU5 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | Q91WA3 (/TAS) Q91WA3 (/TAS) Q9GKU5 (/TAS) Q9GKU5 (/TAS) Q9GKU5 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
5 | Q91WA3 (/TAS) Q91WA3 (/TAS) Q9GKU5 (/TAS) Q9GKU5 (/TAS) Q9GKU5 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | B2GUW3 (/IDA) Q96DB2 (/IDA) Q96DB2 (/IDA) Q96DB2 (/IDA) |
|
Histone deacetylase complex GO:0000118
A protein complex that possesses histone deacetylase activity.
|
3 | Q96DB2 (/IDA) Q96DB2 (/IDA) Q96DB2 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | Q96DB2 (/IDA) Q96DB2 (/IDA) Q96DB2 (/IDA) |
|
Histone deacetylase complex GO:0000118
A protein complex that possesses histone deacetylase activity.
|
2 | Q91WA3 (/ISO) Q91WA3 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q91WA3 (/ISO) Q91WA3 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q91WA3 (/ISO) Q91WA3 (/ISO) |
|
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
|
1 | Q7MMB6 (/IDA) |
|
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
|
1 | Q7MMB6 (/IPI) |
