The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Histone deacetylase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Histone deacetylase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 35 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
1020 A0A060VZ47 (/ISS) A0A060VZ47 (/ISS) A0A060XIY4 (/ISS) A0A060XIY4 (/ISS) A0A087XD45 (/ISS) A0A087XD45 (/ISS) A0A087XD45 (/ISS) A0A091CP69 (/ISS) A0A091CP69 (/ISS) A0A091CP69 (/ISS)
(1010 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
56 O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI)
(46 more)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
53 O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI)
(43 more)
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
52 O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP)
(42 more)
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
52 O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS)
(42 more)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
52 O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS)
(42 more)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
51 O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA)
(41 more)
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
51 O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP)
(41 more)
Protein deacetylase activity GO:0033558
Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate.
51 O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA)
(41 more)
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
50 O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA)
(40 more)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
50 O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI)
(40 more)
Cyclin binding GO:0030332
Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis.
50 O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI)
(40 more)
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
50 O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI)
(40 more)
NF-kappaB binding GO:0051059
Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.
50 O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI) O15379 (/IPI)
(40 more)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
8 P56520 (/ISS) Q28DV3 (/ISS) Q5RB76 (/ISS) Q6IRL9 (/ISS) Q6P6W3 (/ISS) Q6P6W3 (/ISS) Q6P6W3 (/ISS) Q803C3 (/ISS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
3 Q6P6W3 (/IMP) Q6P6W3 (/IMP) Q6P6W3 (/IMP)
Deacetylase activity GO:0019213
Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.
3 Q6P6W3 (/IDA) Q6P6W3 (/IDA) Q6P6W3 (/IDA)
GTPase binding GO:0051020
Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP.
3 Q6P6W3 (/IPI) Q6P6W3 (/IPI) Q6P6W3 (/IPI)
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
2 Q7KTS4 (/IDA) Q9VNC2 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 O88895 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 O88895 (/ISO)
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
1 O88895 (/ISO)
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
1 O88895 (/ISO)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 O88895 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 O88895 (/ISO)
Deacetylase activity GO:0019213
Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.
1 O88895 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 O88895 (/ISO)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 Q7KTS4 (/IPI)
Cyclin binding GO:0030332
Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis.
1 O88895 (/ISO)
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
1 O88895 (/IDA)
Protein deacetylase activity GO:0033558
Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate.
1 O88895 (/ISO)
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
1 O88895 (/ISO)
GTPase binding GO:0051020
Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP.
1 O88895 (/ISO)
NF-kappaB binding GO:0051059
Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.
1 O88895 (/ISO)
Repressing transcription factor binding GO:0070491
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.
1 P56520 (/IPI)

There are 81 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
59 O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS)
(49 more)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
59 O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS)
(49 more)
Positive regulation of protein ubiquitination GO:0031398
Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
54 O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS)
(44 more)
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
54 A0A0G2K1C8 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS) O15379 (/ISS)
(44 more)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
52 O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS)
(42 more)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
50 O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA)
(40 more)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
50 O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP)
(40 more)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
50 O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA)
(40 more)
Protein deacetylation GO:0006476
The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic
50 O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA)
(40 more)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
50 O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS)
(40 more)
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
50 O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS)
(40 more)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
50 O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA)
(40 more)
Positive regulation of TOR signaling GO:0032008
Any process that activates or increases the frequency, rate or extent of TOR signaling.
50 O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP)
(40 more)
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
50 O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA)
(40 more)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
50 O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS)
(40 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
50 O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP)
(40 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
50 O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA)
(40 more)
Negative regulation of JNK cascade GO:0046329
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.
50 O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP)
(40 more)
Spindle assembly GO:0051225
The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.
50 O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP) O15379 (/IMP)
(40 more)
Cellular response to fluid shear stress GO:0071498
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
50 O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA)
(40 more)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
9 O88895 (/ISS) P56520 (/ISS) Q28DV3 (/ISS) Q5RB76 (/ISS) Q6IRL9 (/ISS) Q6P6W3 (/ISS) Q6P6W3 (/ISS) Q6P6W3 (/ISS) Q803C3 (/ISS)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
5 O88895 (/ISS) Q5RB76 (/ISS) Q6P6W3 (/ISS) Q6P6W3 (/ISS) Q6P6W3 (/ISS)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
5 O88895 (/ISS) Q5RB76 (/ISS) Q6P6W3 (/ISS) Q6P6W3 (/ISS) Q6P6W3 (/ISS)
Positive regulation of TOR signaling GO:0032008
Any process that activates or increases the frequency, rate or extent of TOR signaling.
5 O88895 (/ISS) Q5RB76 (/ISS) Q6P6W3 (/ISS) Q6P6W3 (/ISS) Q6P6W3 (/ISS)
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
5 O88895 (/ISS) Q5RB76 (/ISS) Q6P6W3 (/ISS) Q6P6W3 (/ISS) Q6P6W3 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
5 O88895 (/ISS) Q5RB76 (/ISS) Q6P6W3 (/ISS) Q6P6W3 (/ISS) Q6P6W3 (/ISS)
Cellular response to fluid shear stress GO:0071498
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
5 O88895 (/ISS) Q5RB76 (/ISS) Q6P6W3 (/ISS) Q6P6W3 (/ISS) Q6P6W3 (/ISS)
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
3 O88895 (/IMP) Q7KTS4 (/IMP) Q9VNC2 (/IMP)
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
3 Q6P6W3 (/IEP) Q6P6W3 (/IEP) Q6P6W3 (/IEP)
Negative regulation of interleukin-1 production GO:0032692
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production.
3 Q6P6W3 (/IMP) Q6P6W3 (/IMP) Q6P6W3 (/IMP)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
3 Q6P6W3 (/IMP) Q6P6W3 (/IMP) Q6P6W3 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
3 Q6P6W3 (/IEP) Q6P6W3 (/IEP) Q6P6W3 (/IEP)
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
3 Q6P6W3 (/IMP) Q6P6W3 (/IMP) Q6P6W3 (/IMP)
Negative regulation of protein export from nucleus GO:0046826
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm.
3 Q6P6W3 (/IMP) Q6P6W3 (/IMP) Q6P6W3 (/IMP)
Histone H3 deacetylation GO:0070932
The modification of histone H3 by the removal of one or more acetyl groups.
3 Q6P6W3 (/IEP) Q6P6W3 (/IEP) Q6P6W3 (/IEP)
Cellular response to mechanical stimulus GO:0071260
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
3 Q6P6W3 (/IEP) Q6P6W3 (/IEP) Q6P6W3 (/IEP)
Cellular response to parathyroid hormone stimulus GO:0071374
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus.
3 Q6P6W3 (/IEP) Q6P6W3 (/IEP) Q6P6W3 (/IEP)
Response to dexamethasone GO:0071548
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.
3 Q6P6W3 (/IEP) Q6P6W3 (/IEP) Q6P6W3 (/IEP)
Positive regulation of type B pancreatic cell apoptotic process GO:2000676
Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process.
3 Q6P6W3 (/IMP) Q6P6W3 (/IMP) Q6P6W3 (/IMP)
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
2 Q7KTS4 (/IGI) Q9VNC2 (/IGI)
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
2 Q7KTS4 (/IMP) Q9VNC2 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 Q7KTS4 (/IDA) Q9VNC2 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 Q7KTS4 (/IMP) Q9VNC2 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 O88895 (/IGI)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 O88895 (/ISO)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
1 Q803C3 (/IMP)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
1 Q803C3 (/IMP)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 O88895 (/ISO)
Protein deacetylation GO:0006476
The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic
1 O88895 (/ISO)
Protein deacetylation GO:0006476
The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic
1 Q5RB76 (/ISS)
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
1 O88895 (/IDA)
Negative regulation of neuroblast proliferation GO:0007406
Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts.
1 Q9VNC2 (/IGI)
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
1 Q803C3 (/IGI)
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
1 Q7KTS4 (/IDA)
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
1 O88895 (/IGI)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
1 Q7KTS4 (/IMP)
Positive regulation of protein ubiquitination GO:0031398
Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
1 O88895 (/IMP)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
1 O88895 (/ISO)
Positive regulation of TOR signaling GO:0032008
Any process that activates or increases the frequency, rate or extent of TOR signaling.
1 O88895 (/ISO)
Negative regulation of interleukin-1 production GO:0032692
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production.
1 O88895 (/ISO)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
1 O88895 (/ISO)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
1 O88895 (/IGI)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
1 O88895 (/IMP)
Regulation of multicellular organism growth GO:0040014
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
1 O88895 (/IGI)
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
1 O88895 (/ISO)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
1 O88895 (/IMP)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 O88895 (/IDA)
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
1 O88895 (/ISO)
Cell dedifferentiation GO:0043697
The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.
1 Q9VNC2 (/IGI)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 O88895 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 O88895 (/ISO)
Negative regulation of JNK cascade GO:0046329
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.
1 O88895 (/ISO)
Negative regulation of protein export from nucleus GO:0046826
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm.
1 O88895 (/ISO)
Posterior lateral line development GO:0048916
The process whose specific outcome is the progression of the posterior lateral line over time, from its formation to the mature structure. The posterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the body and trunk of all fishes and most amphibians. The posterior lateral line develops from cranial ectodermal placodes situated behind the ear.
1 Q803C3 (/IMP)
Spindle assembly GO:0051225
The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.
1 O88895 (/ISO)
Histone H4 deacetylation GO:0070933
The modification of histone H4 by the removal of one or more acetyl groups.
1 O88895 (/IDA)
Cellular response to fluid shear stress GO:0071498
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
1 O88895 (/ISO)
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
1 O88895 (/IMP)
Histone H4-K12 deacetylation GO:1990679
The modification of histone H4 by the removal of an acetyl group from lysine at position 12 of the histone.
1 O88895 (/IDA)
Positive regulation of type B pancreatic cell apoptotic process GO:2000676
Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process.
1 O88895 (/ISO)
Negative regulation of cardiac muscle cell differentiation GO:2000726
Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation.
1 O88895 (/IMP)

There are 28 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
56 O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA)
(46 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
56 O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA)
(46 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
54 O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS)
(44 more)
Histone deacetylase complex GO:0000118
A protein complex that possesses histone deacetylase activity.
52 O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS)
(42 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
52 O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS)
(42 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
52 O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS) O15379 (/TAS)
(42 more)
Histone deacetylase complex GO:0000118
A protein complex that possesses histone deacetylase activity.
50 O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA)
(40 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
50 O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA)
(40 more)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
50 O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA)
(40 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
50 O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA)
(40 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
50 O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA)
(40 more)
Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
50 O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA)
(40 more)
Mitotic spindle GO:0072686
A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
50 O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA) O15379 (/IDA)
(40 more)
Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
9 O88895 (/ISS) P56520 (/ISS) Q28DV3 (/ISS) Q5RB76 (/ISS) Q6IRL9 (/ISS) Q6P6W3 (/ISS) Q6P6W3 (/ISS) Q6P6W3 (/ISS) Q803C3 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 O88895 (/ISS) P56520 (/ISS) Q28DV3 (/ISS) Q4SFA0 (/ISS) Q5RB76 (/ISS) Q6IRL9 (/ISS) Q803C3 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 P56520 (/ISS) Q28DV3 (/ISS) Q4SFA0 (/ISS) Q5RB76 (/ISS) Q6IRL9 (/ISS) Q803C3 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 O88895 (/ISS) Q5RB76 (/ISS) Q6P6W3 (/ISS) Q6P6W3 (/ISS) Q6P6W3 (/ISS)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
3 Q6P6W3 (/IDA) Q6P6W3 (/IDA) Q6P6W3 (/IDA)
Histone deacetylase complex GO:0000118
A protein complex that possesses histone deacetylase activity.
1 O88895 (/ISO)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
1 O88895 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O88895 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 O88895 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O88895 (/ISO)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 O88895 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O88895 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O88895 (/ISO)
Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
1 O88895 (/ISO)
Mitotic spindle GO:0072686
A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
1 O88895 (/ISO)
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