The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Isopropylmalate Dehydrogenase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 4: 3-isopropylmalate dehydrogenase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
3-isopropylmalate dehydrogenase activity GO:0003862
Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+.
72 P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA)
(62 more)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
66 P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA)
(56 more)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
66 P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA)
(56 more)
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
66 P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA)
(56 more)
3-isopropylmalate dehydrogenase activity GO:0003862
Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+.
7 Q9KP82 (/ISS) Q9KP82 (/ISS) Q9KP82 (/ISS) Q9KP82 (/ISS) Q9KP82 (/ISS) Q9KP82 (/ISS) Q9KP82 (/ISS)
3-isopropylmalate dehydrogenase activity GO:0003862
Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+.
6 P93832 (/IMP) Q9FMT1 (/IMP) Q9FMT1 (/IMP) Q9FMT1 (/IMP) Q9SA14 (/IMP) Q9SA14 (/IMP)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P93832 (/IDA)
NAD+ binding GO:0070403
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
1 P93832 (/IDA)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Leucine biosynthetic process GO:0009098
The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.
72 P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA)
(62 more)
Leucine biosynthetic process GO:0009098
The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.
72 P30125 (/IMP) P30125 (/IMP) P30125 (/IMP) P30125 (/IMP) P30125 (/IMP) P30125 (/IMP) P30125 (/IMP) P30125 (/IMP) P30125 (/IMP) P30125 (/IMP)
(62 more)
Cellular response to amino acid starvation GO:0034198
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
66 P30125 (/IMP) P30125 (/IMP) P30125 (/IMP) P30125 (/IMP) P30125 (/IMP) P30125 (/IMP) P30125 (/IMP) P30125 (/IMP) P30125 (/IMP) P30125 (/IMP)
(56 more)
Leucine biosynthetic process GO:0009098
The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.
7 Q9KP82 (/ISS) Q9KP82 (/ISS) Q9KP82 (/ISS) Q9KP82 (/ISS) Q9KP82 (/ISS) Q9KP82 (/ISS) Q9KP82 (/ISS)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
5 Q9FMT1 (/IEP) Q9FMT1 (/IEP) Q9FMT1 (/IEP) Q9SA14 (/IEP) Q9SA14 (/IEP)
Embryo sac development GO:0009553
The process whose specific outcome is the progression of the embryo sac over time, from its formation to the mature structure. The process begins with the meiosis of the megasporocyte to form four haploid megaspores. Three of the megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. The two polar nuclei fuse resulting in a mononucleate diploid endosperm mother cell. The three antipodal cells degenerate.
4 P93832 (/IMP) Q9FMT1 (/IMP) Q9FMT1 (/IMP) Q9FMT1 (/IMP)
Pollen development GO:0009555
The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.
4 P93832 (/IMP) Q9FMT1 (/IMP) Q9FMT1 (/IMP) Q9FMT1 (/IMP)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
3 Q9FMT1 (/IEP) Q9FMT1 (/IEP) Q9FMT1 (/IEP)
Response to jasmonic acid GO:0009753
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.
3 Q9FMT1 (/IEP) Q9FMT1 (/IEP) Q9FMT1 (/IEP)
Glucosinolate biosynthetic process GO:0019761
The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae.
3 Q9FMT1 (/IMP) Q9FMT1 (/IMP) Q9FMT1 (/IMP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
66 P30125 (/EXP) P30125 (/EXP) P30125 (/EXP) P30125 (/EXP) P30125 (/EXP) P30125 (/EXP) P30125 (/EXP) P30125 (/EXP) P30125 (/EXP) P30125 (/EXP)
(56 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
66 P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA) P30125 (/IDA)
(56 more)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
6 P93832 (/IDA) Q9FMT1 (/IDA) Q9FMT1 (/IDA) Q9FMT1 (/IDA) Q9SA14 (/IDA) Q9SA14 (/IDA)
Plastid GO:0009536
Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
6 P93832 (/ISS) Q9FMT1 (/ISS) Q9FMT1 (/ISS) Q9FMT1 (/ISS) Q9SA14 (/ISS) Q9SA14 (/ISS)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
6 P93832 (/IDA) Q9FMT1 (/IDA) Q9FMT1 (/IDA) Q9FMT1 (/IDA) Q9SA14 (/IDA) Q9SA14 (/IDA)
Plastid GO:0009536
Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
2 Q9SA14 (/IDA) Q9SA14 (/IDA)
Thylakoid GO:0009579
A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.
2 Q9SA14 (/IDA) Q9SA14 (/IDA)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
1 P93832 (/IDA)
CATH-Gene3D is a Global Biodata Core Resource Learn more...