The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 47: serine palmitoyltransferase 2 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 P40970 (/IPI) P40970 (/IPI) P40970 (/IPI) P40970 (/IPI) P40970 (/IPI) P40970 (/IPI) P40970 (/IPI) Q9NUV7 (/IPI)
Serine C-palmitoyltransferase activity GO:0004758
Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA.
7 P40970 (/IGI) P40970 (/IGI) P40970 (/IGI) P40970 (/IGI) P40970 (/IGI) P40970 (/IGI) P40970 (/IGI)
Serine C-palmitoyltransferase activity GO:0004758
Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA.
7 P40970 (/IMP) P40970 (/IMP) P40970 (/IMP) P40970 (/IMP) P40970 (/IMP) P40970 (/IMP) P40970 (/IMP)
Serine C-palmitoyltransferase activity GO:0004758
Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA.
3 O15270 (/IDA) O15270 (/IDA) Q9NUV7 (/IDA)
Serine C-palmitoyltransferase activity GO:0004758
Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA.
2 Q09925 (/ISO) Q8BG54 (/ISO)
Serine C-palmitoyltransferase activity GO:0004758
Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA.
2 Q3B7D2 (/ISS) Q8BG54 (/ISS)
Serine C-palmitoyltransferase activity GO:0004758
Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA.
2 O15270 (/TAS) O15270 (/TAS)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sphingolipid biosynthetic process GO:0030148
The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
9 P40970 (/IMP) P40970 (/IMP) P40970 (/IMP) P40970 (/IMP) P40970 (/IMP) P40970 (/IMP) P40970 (/IMP) P97363 (/IMP) P97363 (/IMP)
Sphingolipid biosynthetic process GO:0030148
The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
3 P97363 (/ISO) P97363 (/ISO) Q09925 (/ISO)
Sphingolipid biosynthetic process GO:0030148
The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
3 O15270 (/TAS) O15270 (/TAS) Q9NUV7 (/TAS)
Adipose tissue development GO:0060612
The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat.
3 O15270 (/ISS) O15270 (/ISS) Q3B7D2 (/ISS)
Sphingomyelin biosynthetic process GO:0006686
The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine.
2 P97363 (/IMP) P97363 (/IMP)
Sphingolipid biosynthetic process GO:0030148
The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
2 O15270 (/IDA) O15270 (/IDA)
Sphinganine biosynthetic process GO:0046511
The chemical reactions and pathways resulting in the formation of sphinganine, D-erythro-2-amino-1,3-octadecanediol.
2 P97363 (/IDA) P97363 (/IDA)
Sphingosine biosynthetic process GO:0046512
The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.
2 P97363 (/IMP) P97363 (/IMP)
Ceramide biosynthetic process GO:0046513
The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.
2 O15270 (/IDA) O15270 (/IDA)
Ceramide biosynthetic process GO:0046513
The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.
2 P97363 (/IMP) P97363 (/IMP)
Ceramide biosynthetic process GO:0046513
The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.
2 P97363 (/ISO) P97363 (/ISO)
Adipose tissue development GO:0060612
The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat.
2 P97363 (/IMP) P97363 (/IMP)
Positive regulation of lipophagy GO:1904504
Any process that activates or increases the frequency, rate or extent of lipophagy.
2 O15270 (/IDA) O15270 (/IDA)
Positive regulation of lipophagy GO:1904504
Any process that activates or increases the frequency, rate or extent of lipophagy.
2 P97363 (/ISO) P97363 (/ISO)
Sphingolipid biosynthetic process GO:0030148
The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
1 Q3B7D2 (/ISS)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q5AKV0 (/IMP)
Sphingoid biosynthetic process GO:0046520
The chemical reactions and pathways resulting in the formation of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds.
1 Q9NUV7 (/IDA)
Sphingoid biosynthetic process GO:0046520
The chemical reactions and pathways resulting in the formation of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds.
1 Q8BG54 (/ISO)
Sphingoid biosynthetic process GO:0046520
The chemical reactions and pathways resulting in the formation of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds.
1 Q8BG54 (/ISS)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
8 P40970 (/HDA) P40970 (/HDA) P40970 (/HDA) P40970 (/HDA) P40970 (/HDA) P40970 (/HDA) P40970 (/HDA) Q09925 (/HDA)
Serine C-palmitoyltransferase complex GO:0017059
An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine.
7 P40970 (/IMP) P40970 (/IMP) P40970 (/IMP) P40970 (/IMP) P40970 (/IMP) P40970 (/IMP) P40970 (/IMP)
SPOTS complex GO:0035339
A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis.
7 P40970 (/IDA) P40970 (/IDA) P40970 (/IDA) P40970 (/IDA) P40970 (/IDA) P40970 (/IDA) P40970 (/IDA)
Serine C-palmitoyltransferase complex GO:0017059
An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine.
4 P97363 (/ISO) P97363 (/ISO) Q09925 (/ISO) Q8BG54 (/ISO)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
3 O15270 (/TAS) O15270 (/TAS) Q9NUV7 (/TAS)
Serine C-palmitoyltransferase complex GO:0017059
An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine.
3 O15270 (/IDA) O15270 (/IDA) Q9NUV7 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P97363 (/HDA) P97363 (/HDA)
Serine C-palmitoyltransferase complex GO:0017059
An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine.
2 P97363 (/ISA) P97363 (/ISA)
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