The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 44: Aspartate aminotransferase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069
Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
25 A1ZAA5 (/ISS) A5A6K8 (/ISS) A5A6K8 (/ISS) P00503 (/ISS) P00503 (/ISS) P00504 (/ISS) P05201 (/ISS) P13221 (/ISS) P17174 (/ISS) P17174 (/ISS)
(15 more)
L-cysteine:2-oxoglutarate aminotransferase activity GO:0047801
Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate.
22 A5A6K8 (/ISS) A5A6K8 (/ISS) P00503 (/ISS) P00503 (/ISS) P00504 (/ISS) P05201 (/ISS) P08906 (/ISS) P17174 (/ISS) P17174 (/ISS) P17174 (/ISS)
(12 more)
L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069
Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
11 A1ZAA5 (/IDA) P05201 (/IDA) P13221 (/IDA) P17174 (/IDA) P17174 (/IDA) P17174 (/IDA) P17174 (/IDA) P17174 (/IDA) Q7K221 (/IDA) Q7YWB4 (/IDA)
(1 more)
L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069
Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
1 P13221 (/IMP)
L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069
Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
1 P05201 (/ISO)
Phosphatidylserine decarboxylase activity GO:0004609
Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine.
1 P05201 (/IDA)
Carboxylic acid binding GO:0031406
Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
1 P13221 (/IDA)
Carboxylic acid binding GO:0031406
Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
1 P05201 (/ISO)
L-cysteine:2-oxoglutarate aminotransferase activity GO:0047801
Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate.
1 P13221 (/IDA)
L-cysteine:2-oxoglutarate aminotransferase activity GO:0047801
Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate.
1 P05201 (/ISO)

There are 44 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Aspartate metabolic process GO:0006531
The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
25 A1ZAA5 (/ISS) A5A6K8 (/ISS) A5A6K8 (/ISS) P00503 (/ISS) P00503 (/ISS) P00504 (/ISS) P05201 (/ISS) P13221 (/ISS) P17174 (/ISS) P17174 (/ISS)
(15 more)
2-oxoglutarate metabolic process GO:0006103
The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
21 A5A6K8 (/ISS) A5A6K8 (/ISS) P00503 (/ISS) P00503 (/ISS) P00504 (/ISS) P05201 (/ISS) P13221 (/ISS) P17174 (/ISS) P17174 (/ISS) P17174 (/ISS)
(11 more)
Glycerol biosynthetic process GO:0006114
The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
21 A5A6K8 (/ISS) A5A6K8 (/ISS) P00503 (/ISS) P00503 (/ISS) P00504 (/ISS) P08906 (/ISS) P17174 (/ISS) P17174 (/ISS) P17174 (/ISS) P17174 (/ISS)
(11 more)
Glutamate metabolic process GO:0006536
The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.
21 A5A6K8 (/ISS) A5A6K8 (/ISS) P00503 (/ISS) P00503 (/ISS) P00504 (/ISS) P05201 (/ISS) P13221 (/ISS) P17174 (/ISS) P17174 (/ISS) P17174 (/ISS)
(11 more)
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
6 P00504 (/TAS) P17174 (/TAS) P17174 (/TAS) P17174 (/TAS) P17174 (/TAS) P17174 (/TAS)
Aspartate catabolic process GO:0006533
The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
5 P17174 (/IDA) P17174 (/IDA) P17174 (/IDA) P17174 (/IDA) P17174 (/IDA)
Cellular amino acid biosynthetic process GO:0008652
The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
5 P17174 (/TAS) P17174 (/TAS) P17174 (/TAS) P17174 (/TAS) P17174 (/TAS)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
5 P17174 (/IEP) P17174 (/IEP) P17174 (/IEP) P17174 (/IEP) P17174 (/IEP)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
5 P17174 (/IEP) P17174 (/IEP) P17174 (/IEP) P17174 (/IEP) P17174 (/IEP)
Glutamate biosynthetic process GO:0006537
The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.
4 A1ZAA5 (/IDA) Q7K221 (/IDA) Q7YWB4 (/IDA) Q8IHB4 (/IDA)
Oxaloacetate metabolic process GO:0006107
The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle.
2 P05201 (/IDA) P13221 (/IDA)
Glycerol biosynthetic process GO:0006114
The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
2 P05201 (/IDA) P13221 (/IDA)
Glutamate catabolic process to 2-oxoglutarate GO:0019551
The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate.
2 P05201 (/IDA) P13221 (/IDA)
Oxaloacetate metabolic process GO:0006107
The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle.
1 P05201 (/ISO)
Glycerol biosynthetic process GO:0006114
The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
1 P05201 (/ISO)
Cellular amino acid metabolic process GO:0006520
The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
1 P00504 (/TAS)
Aspartate metabolic process GO:0006531
The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
1 P13221 (/IDA)
Aspartate metabolic process GO:0006531
The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
1 P05201 (/ISO)
Aspartate biosynthetic process GO:0006532
The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
1 P05201 (/IDA)
Aspartate catabolic process GO:0006533
The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
1 P05201 (/ISO)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P05201 (/IDA)
Response to carbohydrate GO:0009743
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.
1 P13221 (/IEP)
Glutamate catabolic process to aspartate GO:0019550
The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including aspartate.
1 P05201 (/IDA)
Glutamate catabolic process to 2-oxoglutarate GO:0019551
The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate.
1 P05201 (/ISO)
Positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511
Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity.
1 P13221 (/IMP)
Positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511
Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity.
1 P05201 (/ISO)
Negative regulation of collagen biosynthetic process GO:0032966
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
1 P13221 (/IMP)
Negative regulation of collagen biosynthetic process GO:0032966
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
1 P05201 (/ISO)
Response to immobilization stress GO:0035902
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile.
1 P13221 (/IEP)
Dicarboxylic acid metabolic process GO:0043648
The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-).
1 P13221 (/IDA)
Dicarboxylic acid metabolic process GO:0043648
The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-).
1 P13221 (/IMP)
Dicarboxylic acid metabolic process GO:0043648
The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-).
1 P05201 (/ISO)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 P13221 (/IEP)
Negative regulation of cytosolic calcium ion concentration GO:0051481
Any process that decreases the concentration of calcium ions in the cytosol.
1 P13221 (/IMP)
Negative regulation of cytosolic calcium ion concentration GO:0051481
Any process that decreases the concentration of calcium ions in the cytosol.
1 P05201 (/ISO)
Negative regulation of mitochondrial depolarization GO:0051902
Any process that stops, prevents, or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive.
1 P13221 (/IMP)
Negative regulation of mitochondrial depolarization GO:0051902
Any process that stops, prevents, or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive.
1 P05201 (/ISO)
Fatty acid homeostasis GO:0055089
Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell.
1 P05201 (/IDA)
Transdifferentiation GO:0060290
The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.
1 P13221 (/IMP)
Transdifferentiation GO:0060290
The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.
1 P05201 (/ISO)
Cellular response to mechanical stimulus GO:0071260
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 P13221 (/IDA)
Cellular response to mechanical stimulus GO:0071260
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 P05201 (/ISO)
Response to transition metal nanoparticle GO:1990267
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transition metal nanoparticle.
1 P13221 (/IDA)
Response to transition metal nanoparticle GO:1990267
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transition metal nanoparticle.
1 P05201 (/ISO)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
12 A0A140VK69 (/IDA) A0A140VK69 (/IDA) A0A140VK69 (/IDA) A0A140VK69 (/IDA) A0A140VK69 (/IDA) P05201 (/IDA) P13221 (/IDA) P17174 (/IDA) P17174 (/IDA) P17174 (/IDA)
(2 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
10 A0A140VK69 (/IDA) A0A140VK69 (/IDA) A0A140VK69 (/IDA) A0A140VK69 (/IDA) A0A140VK69 (/IDA) P17174 (/IDA) P17174 (/IDA) P17174 (/IDA) P17174 (/IDA) P17174 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 P00504 (/TAS) P13221 (/TAS) P17174 (/TAS) P17174 (/TAS) P17174 (/TAS) P17174 (/TAS) P17174 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 P13221 (/IDA) P17174 (/IDA) P17174 (/IDA) P17174 (/IDA) P17174 (/IDA) P17174 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 P17174 (/HDA) P17174 (/HDA) P17174 (/HDA) P17174 (/HDA) P17174 (/HDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
5 P17174 (/HDA) P17174 (/HDA) P17174 (/HDA) P17174 (/HDA) P17174 (/HDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
4 A1ZAA5 (/ISS) Q7K221 (/ISS) Q7YWB4 (/ISS) Q8IHB4 (/ISS)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
4 A1ZAA5 (/ISM) Q7K221 (/ISM) Q7YWB4 (/ISM) Q8IHB4 (/ISM)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 A1ZAA5 (/HDA) Q7K221 (/HDA) Q7YWB4 (/HDA) Q8IHB4 (/HDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P05201 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P05201 (/ISO)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 P13221 (/IDA)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 P05201 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P05201 (/ISO)
Axon terminus GO:0043679
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
1 P13221 (/IDA)
Axon terminus GO:0043679
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
1 P05201 (/ISO)
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