The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 43: Cystathionine gamma-lyase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cystathionine gamma-lyase activity GO:0004123
Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+.
12 C8VM61 (/IMP) C8VM61 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP)
(2 more)
Cystathionine gamma-lyase activity GO:0004123
Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+.
10 P31373 (/IDA) P31373 (/IDA) P31373 (/IDA) P31373 (/IDA) P31373 (/IDA) P31373 (/IDA) P31373 (/IDA) P31373 (/IDA) P31373 (/IDA) P31373 (/IDA)
Cysteine-S-conjugate beta-lyase activity GO:0047804
Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate.
10 P31373 (/IDA) P31373 (/IDA) P31373 (/IDA) P31373 (/IDA) P31373 (/IDA) P31373 (/IDA) P31373 (/IDA) P31373 (/IDA) P31373 (/IDA) P31373 (/IDA)
Cystathionine gamma-lyase activity GO:0004123
Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+.
2 C8VM61 (/RCA) C8VM61 (/RCA)

There are 5 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cysteine biosynthetic process via cystathionine GO:0019343
The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine.
12 C8VM61 (/IMP) C8VM61 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP)
(2 more)
Transsulfuration GO:0019346
The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes.
12 C8VM61 (/IMP) C8VM61 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP)
(2 more)
Cysteine biosynthetic process GO:0019344
The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid.
10 P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP) P31373 (/IMP)
Methionine metabolic process GO:0006555
The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
2 C8VM61 (/RCA) C8VM61 (/RCA)
Methionine biosynthetic process GO:0009086
The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
2 C8VM61 (/IMP) C8VM61 (/IMP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
10 P31373 (/HDA) P31373 (/HDA) P31373 (/HDA) P31373 (/HDA) P31373 (/HDA) P31373 (/HDA) P31373 (/HDA) P31373 (/HDA) P31373 (/HDA) P31373 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 P31373 (/HDA) P31373 (/HDA) P31373 (/HDA) P31373 (/HDA) P31373 (/HDA) P31373 (/HDA) P31373 (/HDA) P31373 (/HDA) P31373 (/HDA) P31373 (/HDA)
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