The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Cysteine desulfurase IscS

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
317 O31269 (/IPI) O49543 (/IPI) O49543 (/IPI) P0A6B7 (/IPI) P0A6B7 (/IPI) P0A6B7 (/IPI) P0A6B7 (/IPI) P0A6B7 (/IPI) P0A6B7 (/IPI) P0A6B7 (/IPI)
(307 more)
Cysteine desulfurase activity GO:0031071
Catalysis of the reaction: L-cysteine +
162 O49543 (/IDA) O49543 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA)
(152 more)
Selenocysteine lyase activity GO:0009000
Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor.
155 P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA)
(145 more)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
155 P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA)
(145 more)
Sulfur carrier activity GO:0097163
Covalently binding to sulfur and delivering it to an acceptor molecule.
155 P0A6B7 (/EXP) P0A6B7 (/EXP) P0A6B7 (/EXP) P0A6B7 (/EXP) P0A6B7 (/EXP) P0A6B7 (/EXP) P0A6B7 (/EXP) P0A6B7 (/EXP) P0A6B7 (/EXP) P0A6B7 (/EXP)
(145 more)
Transaminase activity GO:0008483
Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.
7 Q9KTY2 (/ISS) Q9KTY2 (/ISS) Q9KTY2 (/ISS) Q9KTY2 (/ISS) Q9KTY2 (/ISS) Q9KTY2 (/ISS) Q9KTY2 (/ISS)
Cystathionine gamma-lyase activity GO:0004123
Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+.
5 Q3Z9V3 (/ISS) Q486Z0 (/ISS) Q486Z0 (/ISS) Q8IBI5 (/ISS) Q8IBI5 (/ISS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 O49543 (/IDA) O49543 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 O49543 (/IDA) O49543 (/IDA)
Transaminase activity GO:0008483
Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.
2 Q386Y7 (/ISA) Q386Y7 (/ISA)
Cysteine desulfurase activity GO:0031071
Catalysis of the reaction: L-cysteine +
2 Q386Y7 (/IMP) Q386Y7 (/IMP)
Cysteine desulfurase activity GO:0031071
Catalysis of the reaction: L-cysteine +
2 O74351 (/ISO) Q9Z1J3 (/ISO)
Cysteine desulfurase activity GO:0031071
Catalysis of the reaction: L-cysteine +
2 Q54X04 (/ISS) Q9VKD3 (/ISS)
Cystathionine gamma-lyase activity GO:0004123
Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+.
1 P87185 (/NAS)
Cysteine desulfurase activity GO:0031071
Catalysis of the reaction: L-cysteine +
1 Q9Y697 (/EXP)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q9Y697 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q9Z1J3 (/ISO)

There are 25 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Iron-sulfur cluster assembly GO:0016226
The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
158 P0A6B7 (/IMP) P0A6B7 (/IMP) P0A6B7 (/IMP) P0A6B7 (/IMP) P0A6B7 (/IMP) P0A6B7 (/IMP) P0A6B7 (/IMP) P0A6B7 (/IMP) P0A6B7 (/IMP) P0A6B7 (/IMP)
(148 more)
Oxazole or thiazole biosynthetic process GO:0018131
The chemical reactions and pathways resulting in the formation of oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position.
155 P0A6B7 (/IMP) P0A6B7 (/IMP) P0A6B7 (/IMP) P0A6B7 (/IMP) P0A6B7 (/IMP) P0A6B7 (/IMP) P0A6B7 (/IMP) P0A6B7 (/IMP) P0A6B7 (/IMP) P0A6B7 (/IMP)
(145 more)
TRNA pseudouridine synthesis GO:0031119
The intramolecular conversion of uridine to pseudouridine in a tRNA molecule.
155 P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA)
(145 more)
Iron-sulfur cluster assembly GO:0016226
The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
6 O49543 (/IDA) O49543 (/IDA) P25374 (/IDA) P25374 (/IDA) P25374 (/IDA) Q9VKD3 (/IDA)
TRNA wobble uridine modification GO:0002098
The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.
3 P25374 (/IMP) P25374 (/IMP) P25374 (/IMP)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
3 P25374 (/IMP) P25374 (/IMP) P25374 (/IMP)
Iron-sulfur cluster assembly GO:0016226
The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
3 Q486Z0 (/ISS) Q486Z0 (/ISS) Q9VKD3 (/ISS)
TRNA thio-modification GO:0034227
The addition a sulfur atom to a nucleotide in a tRNA molecule.
3 P25374 (/IMP) P25374 (/IMP) P25374 (/IMP)
Mitochondrial tRNA thio-modification GO:0070903
The addition a sulfur atom to a nucleotide in a mitochondrial tRNA molecule.
3 P25374 (/IMP) P25374 (/IMP) P25374 (/IMP)
Sulfur amino acid metabolic process GO:0000096
The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.
2 Q386Y7 (/ISA) Q386Y7 (/ISA)
TRNA wobble position uridine thiolation GO:0002143
The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.
2 Q386Y7 (/TAS) Q386Y7 (/TAS)
Cysteine metabolic process GO:0006534
The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid.
2 Q8IBI5 (/ISS) Q8IBI5 (/ISS)
Iron-sulfur cluster assembly GO:0016226
The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
2 Q386Y7 (/TAS) Q386Y7 (/TAS)
Iron incorporation into metallo-sulfur cluster GO:0018283
The incorporation of iron into a metallo-sulfur cluster.
2 Q9Y697 (/IDA) Q9Z1J3 (/IDA)
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
2 Q386Y7 (/ISA) Q386Y7 (/ISA)
Sulfur amino acid metabolic process GO:0000096
The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.
1 Q9Y697 (/TAS)
TRNA wobble position uridine thiolation GO:0002143
The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.
1 O74351 (/IDA)
Selenocysteine metabolic process GO:0016259
The chemical reactions and pathways involving selenocysteine, an essential component of glutathione peroxidase and some other proteins.
1 Q3Z9V3 (/ISS)
Iron incorporation into metallo-sulfur cluster GO:0018283
The incorporation of iron into a metallo-sulfur cluster.
1 Q9Z1J3 (/ISO)
Iron incorporation into metallo-sulfur cluster GO:0018283
The incorporation of iron into a metallo-sulfur cluster.
1 Q54X04 (/ISS)
Molybdopterin cofactor biosynthetic process GO:0032324
The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.
1 Q9Y697 (/TAS)
Small molecule metabolic process GO:0044281
The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
1 Q9Y697 (/TAS)
[2Fe-2S] cluster assembly GO:0044571
The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster.
1 O74351 (/IC)
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
1 Q9Y697 (/TAS)
Mitochondrial tRNA thio-modification GO:0070903
The addition a sulfur atom to a nucleotide in a mitochondrial tRNA molecule.
1 Q9VKD3 (/ISS)

There are 22 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
159 P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA) P0A6B7 (/IDA)
(149 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
11 O49543 (/IDA) O49543 (/IDA) P25374 (/IDA) P25374 (/IDA) P25374 (/IDA) Q386Y7 (/IDA) Q386Y7 (/IDA) Q8IBI5 (/IDA) Q8IBI5 (/IDA) Q9Y697 (/IDA)
(1 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 P25374 (/IDA) P25374 (/IDA) P25374 (/IDA) Q9VKD3 (/IDA) Q9Y697 (/IDA) Q9Z1J3 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 P25374 (/HDA) P25374 (/HDA) P25374 (/HDA) Q9Z1J3 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 Q54X04 (/ISS) Q5RDE7 (/ISS) Q99P39 (/ISS) Q9VKD3 (/ISS)
L-cysteine desulfurase complex GO:1990221
A protein complex capable of cysteine desulfurase activity decomposing L-cysteine to L-alanine and sulfur. It belongs to a ubiquitous family of pyridoxal 5-phosphate (PLP)-dependent enzymes. In E. coli it consists of a SufS dimer.
4 P25374 (/IPI) P25374 (/IPI) P25374 (/IPI) Q9VKD3 (/IPI)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P25374 (/IMP) P25374 (/IMP) P25374 (/IMP)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 Q5QP19 (/IDA) Q5QP19 (/IDA) Q9Y697 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 Q386Y7 (/IDA) Q386Y7 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 Q9Y697 (/IDA) Q9Z1J3 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 O74351 (/ISO) Q9Z1J3 (/ISO)
Kinetoplast GO:0020023
A sub-structure within the large single mitochondrion of kinetoplastid parasites and which is closely associated with the flagellar pocket and basal body of the flagellum.
2 Q386Y7 (/IDA) Q386Y7 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9Z1J3 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9Y697 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9Z1J3 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9Z1J3 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9Y697 (/TAS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q9Y697 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9Z1J3 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q54X04 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9Y697 (/TAS)
L-cysteine desulfurase complex GO:1990221
A protein complex capable of cysteine desulfurase activity decomposing L-cysteine to L-alanine and sulfur. It belongs to a ubiquitous family of pyridoxal 5-phosphate (PLP)-dependent enzymes. In E. coli it consists of a SufS dimer.
1 Q9VKD3 (/ISS)
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