The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 15: Aspartate aminotransferase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-tyrosine:2-oxoglutarate aminotransferase activity GO:0004838
Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.
118 P00509 (/IMP) P00509 (/IMP) P00509 (/IMP) P00509 (/IMP) P00509 (/IMP) P00509 (/IMP) P00509 (/IMP) P00509 (/IMP) P00509 (/IMP) P00509 (/IMP)
(108 more)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
118 P00509 (/IDA) P00509 (/IDA) P00509 (/IDA) P00509 (/IDA) P00509 (/IDA) P00509 (/IDA) P00509 (/IDA) P00509 (/IDA) P00509 (/IDA) P00509 (/IDA)
(108 more)
L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069
Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
106 P00509 (/IMP) P00509 (/IMP) P00509 (/IMP) P00509 (/IMP) P00509 (/IMP) P00509 (/IMP) P00509 (/IMP) P00509 (/IMP) P00509 (/IMP) P00509 (/IMP)
(96 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
106 P00509 (/IPI) P00509 (/IPI) P00509 (/IPI) P00509 (/IPI) P00509 (/IPI) P00509 (/IPI) P00509 (/IPI) P00509 (/IPI) P00509 (/IPI) P00509 (/IPI)
(96 more)
L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069
Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
19 P26563 (/ISS) P46248 (/ISS) P46248 (/ISS) P46248 (/ISS) P46643 (/ISS) Q48KA8 (/ISS) Q48KA8 (/ISS) Q48KA8 (/ISS) Q48KA8 (/ISS) Q48KA8 (/ISS)
(9 more)
L-tyrosine:2-oxoglutarate aminotransferase activity GO:0004838
Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.
12 P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA)
(2 more)
Aromatic-amino-acid:2-oxoglutarate aminotransferase activity GO:0008793
Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.
12 P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA)
(2 more)
L-leucine:2-oxoglutarate aminotransferase activity GO:0050048
Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.
12 P04693 (/IMP) P04693 (/IMP) P04693 (/IMP) P04693 (/IMP) P04693 (/IMP) P04693 (/IMP) P04693 (/IMP) P04693 (/IMP) P04693 (/IMP) P04693 (/IMP)
(2 more)
L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069
Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
2 B9DG21 (/IDA) P46643 (/IDA)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
1 P46643 (/IDA)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-phenylalanine biosynthetic process GO:0009094
The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid.
106 P00509 (/IGI) P00509 (/IGI) P00509 (/IGI) P00509 (/IGI) P00509 (/IGI) P00509 (/IGI) P00509 (/IGI) P00509 (/IGI) P00509 (/IGI) P00509 (/IGI)
(96 more)
L-phenylalanine biosynthetic process from chorismate via phenylpyruvate GO:0033585
The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate phenylpyruvate.
106 P00509 (/IMP) P00509 (/IMP) P00509 (/IMP) P00509 (/IMP) P00509 (/IMP) P00509 (/IMP) P00509 (/IMP) P00509 (/IMP) P00509 (/IMP) P00509 (/IMP)
(96 more)
Aspartate biosynthetic process GO:0006532
The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
14 Q48KA8 (/ISS) Q48KA8 (/ISS) Q48KA8 (/ISS) Q48KA8 (/ISS) Q48KA8 (/ISS) Q884D0 (/ISS) Q884D0 (/ISS) Q884D0 (/ISS) Q884D0 (/ISS) Q884D0 (/ISS)
(4 more)
Aspartate biosynthetic process GO:0006532
The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
12 P04693 (/IGI) P04693 (/IGI) P04693 (/IGI) P04693 (/IGI) P04693 (/IGI) P04693 (/IGI) P04693 (/IGI) P04693 (/IGI) P04693 (/IGI) P04693 (/IGI)
(2 more)
Leucine biosynthetic process GO:0009098
The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.
12 P04693 (/IMP) P04693 (/IMP) P04693 (/IMP) P04693 (/IMP) P04693 (/IMP) P04693 (/IMP) P04693 (/IMP) P04693 (/IMP) P04693 (/IMP) P04693 (/IMP)
(2 more)
Tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate GO:0019292
The chemical reactions and pathways resulting in the formation of tyrosine from other compounds, including chorismate, via the intermediate 4-hydroxyphenylpyruvate.
12 P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA)
(2 more)
L-phenylalanine biosynthetic process from chorismate via phenylpyruvate GO:0033585
The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate phenylpyruvate.
12 P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA)
(2 more)
2-oxoglutarate metabolic process GO:0006103
The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
5 P26563 (/ISS) P46248 (/ISS) P46248 (/ISS) P46248 (/ISS) P46643 (/ISS)
Aspartate metabolic process GO:0006531
The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
5 P26563 (/ISS) P46248 (/ISS) P46248 (/ISS) P46248 (/ISS) P46643 (/ISS)
Glutamate metabolic process GO:0006536
The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.
5 P26563 (/ISS) P46248 (/ISS) P46248 (/ISS) P46248 (/ISS) P46643 (/ISS)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
2 B9DG21 (/IEP) P46643 (/IEP)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
1 B9DG21 (/IEP)
L-methionine salvage from methylthioadenosine GO:0019509
The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine.
1 O85746 (/IDA)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
118 P00509 (/IDA) P00509 (/IDA) P00509 (/IDA) P00509 (/IDA) P00509 (/IDA) P00509 (/IDA) P00509 (/IDA) P00509 (/IDA) P00509 (/IDA) P00509 (/IDA)
(108 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
106 P00509 (/HDA) P00509 (/HDA) P00509 (/HDA) P00509 (/HDA) P00509 (/HDA) P00509 (/HDA) P00509 (/HDA) P00509 (/HDA) P00509 (/HDA) P00509 (/HDA)
(96 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
12 P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA) P04693 (/IDA)
(2 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P46643 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P26563 (/ISS)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 B9DG21 (/IDA)
Plastid GO:0009536
Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
1 B9DG21 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
1 B9DG21 (/IDA)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
1 B9DG21 (/IDA)
Stromule GO:0010319
Thin filamentous structure extending from the surface of all plastid types examined so far, including chloroplast, proplastid, etioplast, leucoplast, amyloplast, and chromoplast. In general, stromules are more abundant in tissues containing non-green plastids, and in cells containing smaller plastids. The primary function of stromules is still unresolved, although the presence of stromules markedly increases the plastid surface area, potentially increasing transport to and from the cytosol. Other functions of stromules, such as transfer of macromolecules between plastids and starch granule formation in cereal endosperm, may be restricted to particular tissues and cell types.
1 B9DG21 (/IDA)
Apoplast GO:0048046
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
1 B9DG21 (/IDA)
CATH-Gene3D is a Global Biodata Core Resource Learn more...