The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 2: Gamma-glutamyl phosphate reductase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutamate-5-semialdehyde dehydrogenase activity GO:0004350
Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH.
35 P07004 (/IDA) P07004 (/IDA) P07004 (/IDA) P07004 (/IDA) P07004 (/IDA) P07004 (/IDA) P07004 (/IDA) P07004 (/IDA) P07004 (/IDA) P07004 (/IDA)
(25 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
27 P07004 (/IPI) P07004 (/IPI) P07004 (/IPI) P07004 (/IPI) P07004 (/IPI) P07004 (/IPI) P07004 (/IPI) P07004 (/IPI) P07004 (/IPI) P07004 (/IPI)
(17 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
27 P07004 (/IDA) P07004 (/IDA) P07004 (/IDA) P07004 (/IDA) P07004 (/IDA) P07004 (/IDA) P07004 (/IDA) P07004 (/IDA) P07004 (/IDA) P07004 (/IDA)
(17 more)
Glutamate-5-semialdehyde dehydrogenase activity GO:0004350
Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH.
9 Q5R4M8 (/ISS) Q5R4M8 (/ISS) Q8EHU1 (/ISS) Q9KPT9 (/ISS) Q9KPT9 (/ISS) Q9KPT9 (/ISS) Q9KPT9 (/ISS) Q9KPT9 (/ISS) Q9Z110 (/ISS)
Glutamate 5-kinase activity GO:0004349
Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+).
4 P54886 (/IDA) P54886 (/IDA) P54886 (/IDA) Q9Z110 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
3 P54886 (/HDA) P54886 (/HDA) P54886 (/HDA)
Glutamate 5-kinase activity GO:0004349
Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+).
3 P54886 (/IMP) P54886 (/IMP) P54886 (/IMP)
Glutamate-5-semialdehyde dehydrogenase activity GO:0004350
Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH.
3 P54886 (/IMP) P54886 (/IMP) P54886 (/IMP)
Delta1-pyrroline-5-carboxylate synthetase activity GO:0017084
Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate.
3 P54887 (/ISS) P54887 (/ISS) Q9VNW6 (/ISS)
Glutamate 5-kinase activity GO:0004349
Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+).
2 Q5R4M8 (/ISS) Q5R4M8 (/ISS)
Glutamate-5-semialdehyde dehydrogenase activity GO:0004350
Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH.
2 Q9UT44 (/ISO) Q9Z110 (/ISO)
Glutamate-5-semialdehyde dehydrogenase activity GO:0004350
Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH.
2 Q5B0Y1 (/RCA) Q5B0Y1 (/RCA)
Glutamate 5-kinase activity GO:0004349
Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+).
1 Q9Z110 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q9Z110 (/ISO)

There are 28 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-proline biosynthetic process GO:0055129
The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
24 P07004 (/IMP) P07004 (/IMP) P07004 (/IMP) P07004 (/IMP) P07004 (/IMP) P07004 (/IMP) P07004 (/IMP) P07004 (/IMP) P07004 (/IMP) P07004 (/IMP)
(14 more)
Proline biosynthetic process GO:0006561
The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
10 O04226 (/IMP) P54886 (/IMP) P54886 (/IMP) P54886 (/IMP) P54887 (/IMP) P54887 (/IMP) P54888 (/IMP) P54888 (/IMP) Q941T1 (/IMP) Q941T1 (/IMP)
Proline biosynthetic process GO:0006561
The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
10 Q5R4M8 (/ISS) Q5R4M8 (/ISS) Q8EHU1 (/ISS) Q9KPT9 (/ISS) Q9KPT9 (/ISS) Q9KPT9 (/ISS) Q9KPT9 (/ISS) Q9KPT9 (/ISS) Q9VNW6 (/ISS) Q9Z110 (/ISS)
Proline biosynthetic process GO:0006561
The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
8 P54885 (/IDA) P54885 (/IDA) P54885 (/IDA) P54885 (/IDA) P54885 (/IDA) P54885 (/IDA) P54885 (/IDA) P54885 (/IDA)
Proline biosynthetic process GO:0006561
The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
5 P54886 (/TAS) P54886 (/TAS) P54886 (/TAS) P54887 (/TAS) P54887 (/TAS)
Cellular amino acid biosynthetic process GO:0008652
The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
4 P54886 (/TAS) P54886 (/TAS) P54886 (/TAS) Q9Z110 (/TAS)
Pollen development GO:0009555
The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.
4 P54887 (/IMP) P54887 (/IMP) P54888 (/IMP) P54888 (/IMP)
Glutamate metabolic process GO:0006536
The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.
3 P54886 (/IMP) P54886 (/IMP) P54886 (/IMP)
Glutamate metabolic process GO:0006536
The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.
3 Q5R4M8 (/ISS) Q5R4M8 (/ISS) Q9Z110 (/ISS)
Ornithine biosynthetic process GO:0006592
The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.
3 P54886 (/IMP) P54886 (/IMP) P54886 (/IMP)
Citrulline biosynthetic process GO:0019240
The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.
3 P54886 (/IMP) P54886 (/IMP) P54886 (/IMP)
Citrulline biosynthetic process GO:0019240
The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.
3 Q5R4M8 (/ISS) Q5R4M8 (/ISS) Q9Z110 (/ISS)
Proline metabolic process GO:0006560
The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
2 Q5B0Y1 (/RCA) Q5B0Y1 (/RCA)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
2 P54887 (/IMP) P54887 (/IMP)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
2 P54887 (/IEP) P54887 (/IEP)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
2 P54887 (/IGI) P54887 (/IGI)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
2 P54887 (/IEP) P54887 (/IEP)
Embryo development ending in seed dormancy GO:0009793
The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana.
2 P54888 (/IMP) P54888 (/IMP)
Hyperosmotic salinity response GO:0042538
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
2 P54887 (/IMP) P54887 (/IMP)
Root development GO:0048364
The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo.
2 P54887 (/IMP) P54887 (/IMP)
Detoxification of cadmium ion GO:0071585
Any process that reduces or removes the toxicity of cadmium ion. These may include transport of cadmium away from sensitive areas and to compartments or complexes whose purpose is sequestration of cadmium ion.
2 Q6FUU0 (/IMP) Q6FUU0 (/IMP)
Glutamate metabolic process GO:0006536
The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.
1 Q9Z110 (/ISO)
Proline biosynthetic process GO:0006561
The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
1 Q9UT44 (/EXP)
Proline biosynthetic process GO:0006561
The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
1 Q9Z110 (/ISO)
Ornithine biosynthetic process GO:0006592
The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.
1 Q9Z110 (/ISO)
Response to temperature stimulus GO:0009266
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.
1 D3ZIE9 (/IDA)
Response to temperature stimulus GO:0009266
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.
1 Q9Z110 (/ISO)
Citrulline biosynthetic process GO:0019240
The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.
1 Q9Z110 (/ISO)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
29 P07004 (/IDA) P07004 (/IDA) P07004 (/IDA) P07004 (/IDA) P07004 (/IDA) P07004 (/IDA) P07004 (/IDA) P07004 (/IDA) P07004 (/IDA) P07004 (/IDA)
(19 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
12 P9WHV1 (/HDA) P9WHV1 (/HDA) P9WHV1 (/HDA) P9WHV1 (/HDA) P9WHV1 (/HDA) P9WHV1 (/HDA) P9WHV1 (/HDA) P9WHV1 (/HDA) P9WHV1 (/HDA) P9WHV1 (/HDA)
(2 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
11 P9WHV1 (/HDA) P9WHV1 (/HDA) P9WHV1 (/HDA) P9WHV1 (/HDA) P9WHV1 (/HDA) P9WHV1 (/HDA) P9WHV1 (/HDA) P9WHV1 (/HDA) P9WHV1 (/HDA) P9WHV1 (/HDA)
(1 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 P54885 (/HDA) P54885 (/HDA) P54885 (/HDA) P54885 (/HDA) P54885 (/HDA) P54885 (/HDA) P54885 (/HDA) P54885 (/HDA) Q9UT44 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 P54885 (/HDA) P54885 (/HDA) P54885 (/HDA) P54885 (/HDA) P54885 (/HDA) P54885 (/HDA) P54885 (/HDA) P54885 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 P54887 (/IDA) P54887 (/IDA) P54888 (/IDA) P54888 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 D3ZIE9 (/IDA) P54886 (/IDA) P54886 (/IDA) P54886 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
4 P54887 (/IDA) P54887 (/IDA) P54888 (/IDA) P54888 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
3 P54886 (/TAS) P54886 (/TAS) P54886 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P54889 (/HDA) Q9Z110 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q5R4M8 (/ISS) Q5R4M8 (/ISS)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
2 P54888 (/IDA) P54888 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P54887 (/IDA) P54887 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9Z110 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q9VNW6 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9Z110 (/ISO)
Mitochondrial membrane GO:0031966
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
1 D3ZIE9 (/IDA)
Mitochondrial membrane GO:0031966
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
1 Q9Z110 (/ISO)
CATH-Gene3D is a Global Biodata Core Resource Learn more...