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CATH Superfamily 3.40.50.880

Class I glutamine amidotransferase (GATase) domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 24: Folate gamma-glutamyl hydrolase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Folate gamma-glutamyl hydrolase. [EC: 3.4.19.9]
Tetrahydropteroyl-(gamma-glutamyl)(n) + (n-1) H(2)O = 5,6,7,8- tetrahydrofolate + (n-1) L-glutamate.
  • The enzyme, which occurs only in animals and plants, can be either endo- and/or exopeptidase.
  • It acts on tetrahydropteroyl polyglutamates and their modified forms, as well as the polyglutamates of the folate breakdown product N-(4-aminobenzoyl)-L-glutamate (pABA-Glu).
  • The initial cleavage may release either monoglutamate or poly-gamma- glutamate of two or more residues, depending on the specific enzyme.
  • For example, GGH1 from the plant Arabidopsis thaliana cleaves pentaglutamates, mainly to di- and triglutamates, whereas GGH2 from the same organism yields mainly monoglutamates.
  • The enzyme is lysosomal (and secreted) in animals and vacuolar in plants.
  • Belongs to peptidase family C26.
  • Formerly EC 3.4.12.10 and EC 3.4.22.12.
 13 A0A178W3E6 A0A178W3E6 A7YWG4 O65355 P93164 Q54HL4 Q54LN4 Q62867 Q92820 Q9SYL6
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