The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"NAD(P)-binding Rossmann-like Domain
".
FunFam 90: NADP-dependent mannitol dehydrogenase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mannitol 2-dehydrogenase (NADP+) activity GO:0050085
Catalysis of the reaction: D-mannitol + NADP(+) = D-fructose + H(+) + NADPH.
|
9 | P0C0Y4 (/IDA) P0C0Y5 (/IDA) P0C0Y5 (/IDA) P87219 (/IDA) Q6CEE9 (/IDA) Q6CEE9 (/IDA) Q8NK50 (/IDA) Q8NK50 (/IDA) Q8NK50 (/IDA) |
|
NADP binding GO:0050661
Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
|
8 | P0C0Y4 (/ISS) P0C0Y5 (/ISS) P0C0Y5 (/ISS) Q6CEE9 (/ISS) Q6CEE9 (/ISS) Q8NK50 (/ISS) Q8NK50 (/ISS) Q8NK50 (/ISS) |
|
Carbonyl reductase (NADPH) activity GO:0004090
Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+.
|
6 | G8BHG4 (/IDA) G8BHG4 (/IDA) G8BHG5 (/IDA) G8BHG5 (/IDA) G8BHG7 (/IDA) G8BHG7 (/IDA) |
|
L-xylulose reductase (NADP+) activity GO:0050038
Catalysis of the reaction: NADP(+) + xylitol = L-xylulose + H(+) + NADPH.
|
6 | Q5ASB1 (/RCA) Q5ASB1 (/RCA) Q5AUB7 (/RCA) Q5AUB7 (/RCA) Q5AVU0 (/RCA) Q5AVU0 (/RCA) |
|
Mannitol 2-dehydrogenase (NADP+) activity GO:0050085
Catalysis of the reaction: D-mannitol + NADP(+) = D-fructose + H(+) + NADPH.
|
6 | Q5ASB1 (/RCA) Q5ASB1 (/RCA) Q5AUB7 (/RCA) Q5AUB7 (/RCA) Q5AVU0 (/RCA) Q5AVU0 (/RCA) |
|
Mannitol 2-dehydrogenase activity GO:0050086
Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH.
|
4 | A2R5T1 (/TAS) A2R5T1 (/TAS) A2R5T1 (/TAS) A2R5T1 (/TAS) |
|
L-xylulose reductase (NADP+) activity GO:0050038
Catalysis of the reaction: NADP(+) + xylitol = L-xylulose + H(+) + NADPH.
|
3 | Q8NK50 (/ISS) Q8NK50 (/ISS) Q8NK50 (/ISS) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | P0C0Y5 (/IDA) P0C0Y5 (/IDA) |
|
Sorbose reductase activity GO:0032115
Catalysis of the reaction: D-glucitol + NADP(+) = L-sorbose + H(+) + NADPH. The reaction may occur, to a minor extent, in the reverse direction.
|
1 | P87219 (/IDA) |
There are 11 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mannitol metabolic process GO:0019594
The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group.
|
8 | P0C0Y4 (/IDA) P0C0Y5 (/IDA) P0C0Y5 (/IDA) Q6CEE9 (/IDA) Q6CEE9 (/IDA) Q8NK50 (/IDA) Q8NK50 (/IDA) Q8NK50 (/IDA) |
|
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
|
8 | G8BHG4 (/IDA) G8BHG4 (/IDA) G8BHG5 (/IDA) G8BHG5 (/IDA) G8BHG6 (/IDA) G8BHG6 (/IDA) G8BHG7 (/IDA) G8BHG7 (/IDA) |
|
Xylulose metabolic process GO:0005997
The chemical reactions and pathways involving xylulose, the ketopentose threo-2-pentulose.
|
6 | Q5ASB1 (/RCA) Q5ASB1 (/RCA) Q5AUB7 (/RCA) Q5AUB7 (/RCA) Q5AVU0 (/RCA) Q5AVU0 (/RCA) |
|
Mannitol metabolic process GO:0019594
The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group.
|
6 | Q5ASB1 (/RCA) Q5ASB1 (/RCA) Q5AUB7 (/RCA) Q5AUB7 (/RCA) Q5AVU0 (/RCA) Q5AVU0 (/RCA) |
|
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
|
6 | P0C0Y4 (/ISS) Q6CEE9 (/ISS) Q6CEE9 (/ISS) Q8NK50 (/ISS) Q8NK50 (/ISS) Q8NK50 (/ISS) |
|
Xylulose metabolic process GO:0005997
The chemical reactions and pathways involving xylulose, the ketopentose threo-2-pentulose.
|
3 | Q8NK50 (/ISS) Q8NK50 (/ISS) Q8NK50 (/ISS) |
|
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
|
3 | Q8NK50 (/ISS) Q8NK50 (/ISS) Q8NK50 (/ISS) |
|
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
|
2 | P0C0Y5 (/IDA) P0C0Y5 (/IDA) |
|
Cellular response to farnesol GO:0097308
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus.
|
2 | Q5AVU0 (/IEP) Q5AVU0 (/IEP) |
|
L-sorbose catabolic process GO:0042850
The chemical reactions and pathways resulting in the breakdown of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose.
|
1 | P87219 (/IDA) |
|
L-sorbose catabolic process GO:0042850
The chemical reactions and pathways resulting in the breakdown of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose.
|
1 | P87219 (/IMP) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q9Y6Z9 (/HDA) |
