The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 283: Glyoxylate/hydroxypyruvate reductase HPR3

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glyoxylate reductase (NADP(+)). [EC: 1.1.1.79]
Glycolate + NADP(+) = glyoxylate + NADPH.
  • Also reduces hydroxypyruvate to glycerate.
  • Has some affinity for NAD(+).
5 A0A178W4H7 A0A178W4H7 Q9CA90 Q9CA90 Q9LE33
Hydroxypyruvate reductase. [EC: 1.1.1.81]
D-glycerate + NAD(P)(+) = hydroxypyruvate + NAD(P)H.
    5 A0A178W4H7 A0A178W4H7 Q9CA90 Q9CA90 Q9LE33
    Hydroxyphenylpyruvate reductase. [EC: 1.1.1.237]
    (1) (R)-3-(4-hydroxyphenyl)lactate + NAD(P)(+) = 3-(4-hydroxyphenyl)pyruvate + NAD(P)H. (2) (R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)(+) = 3-(3,4- dihydroxyphenyl)pyruvate + NAD(P)H.
    • The enzyme participates in the biosynthesis of rosmarinic acid.
    • It belongs to the family of D-isomer-specific 2-hydroxyacid dehydrogenases, and prefers NADPH to NADH.
    1 Q65CJ7
    CATH-Gene3D is a Global Biodata Core Resource Learn more...