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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 220: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-is...

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-beta-hydroxy-Delta(5)-steroid dehydrogenase. [EC: 1.1.1.145]
A 3-beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)-steroid + NADH.
  • Acts on 3-beta-hydroxyandrost-5-en-17-one to form androst-4-ene-3,17- dione and on 3-beta-hydroxypregn-5-en-20-one to form progesterone.
 26 A0A024R0F9 A0A024R0F9 D0G6Y4 D0G6Y4 O35469 O46516 P14060 P14893 P22071 P22072
(16 more...)
Steroid Delta-isomerase. [EC: 5.3.3.1]
A 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid.
    		 26 A0A024R0F9 A0A024R0F9 D0G6Y4 D0G6Y4 O35469 O46516 P14060 P14893 P22071 P22072
    (16 more...)
    3-beta-hydroxysteroid 3-dehydrogenase. [EC: 1.1.1.270]
    A 3-beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + NADPH.
    • The enzyme acts on multiple 3-beta-hydroxysteroids.
    • Participates in the biosynthesis of zemosterol and cholesterol, where it catalyzes the reaction in the opposite direction to that shown.
    • The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.62.
    		 16 P14060 P22071 P24815 P24815 P27364 P27365 P27365 Q2XQY4 Q2XQY4 Q3UI20
    (6 more...)
    3-beta-(or 20-alpha)-hydroxysteroid dehydrogenase. [EC: 1.1.1.210]
    5-alpha-androstan-3-beta,17-beta-diol + NADP(+) = 17-beta-hydroxy-5- alpha-androstan-3-one + NADPH.
    • Also acts on 20-alpha-hydroxysteroids.
    		 16 P14060 P22071 P24815 P24815 P27364 P27365 P27365 Q2XQY4 Q2XQY4 Q3UI20
    (6 more...)
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