The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 211: 3-hydroxybutyrate dehydrogenase type 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor GO:0016628
Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP.
11 C1C4R8 (/ISS) D4A1J4 (/ISS) Q3KPT7 (/ISS) Q3T046 (/ISS) Q561X9 (/ISS) Q561X9 (/ISS) Q9BUT1 (/ISS) Q9BUT1 (/ISS) Q9BUT1 (/ISS) Q9BUT1 (/ISS)
(1 more)
3-hydroxybutyrate dehydrogenase activity GO:0003858
Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH.
5 Q9BUT1 (/IDA) Q9BUT1 (/IDA) Q9BUT1 (/IDA) Q9BUT1 (/IDA) Q9BUT1 (/IDA)
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
5 Q9BUT1 (/IDA) Q9BUT1 (/IDA) Q9BUT1 (/IDA) Q9BUT1 (/IDA) Q9BUT1 (/IDA)
3-hydroxybutyrate dehydrogenase activity GO:0003858
Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH.
1 Q8JZV9 (/ISO)
3-hydroxybutyrate dehydrogenase activity GO:0003858
Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH.
1 Q8JZV9 (/ISS)
Oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor GO:0016628
Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP.
1 Q8JZV9 (/IMP)
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
1 Q8JZV9 (/ISO)
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
1 Q8JZV9 (/ISS)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Siderophore biosynthetic process GO:0019290
The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action.
11 C1C4R8 (/ISS) D4A1J4 (/ISS) Q3KPT7 (/ISS) Q3T046 (/ISS) Q561X9 (/ISS) Q561X9 (/ISS) Q9BUT1 (/ISS) Q9BUT1 (/ISS) Q9BUT1 (/ISS) Q9BUT1 (/ISS)
(1 more)
Iron ion homeostasis GO:0055072
Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
11 C1C4R8 (/ISS) D4A1J4 (/ISS) Q3KPT7 (/ISS) Q3T046 (/ISS) Q561X9 (/ISS) Q561X9 (/ISS) Q9BUT1 (/ISS) Q9BUT1 (/ISS) Q9BUT1 (/ISS) Q9BUT1 (/ISS)
(1 more)
Heme metabolic process GO:0042168
The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
10 C1C4R8 (/ISS) D4A1J4 (/ISS) Q3KPT7 (/ISS) Q3T046 (/ISS) Q8JZV9 (/ISS) Q9BUT1 (/ISS) Q9BUT1 (/ISS) Q9BUT1 (/ISS) Q9BUT1 (/ISS) Q9BUT1 (/ISS)
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
5 Q9BUT1 (/IDA) Q9BUT1 (/IDA) Q9BUT1 (/IDA) Q9BUT1 (/IDA) Q9BUT1 (/IDA)
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
5 Q9BUT1 (/IDA) Q9BUT1 (/IDA) Q9BUT1 (/IDA) Q9BUT1 (/IDA) Q9BUT1 (/IDA)
Ketone body biosynthetic process GO:0046951
The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA.
5 Q9BUT1 (/TAS) Q9BUT1 (/TAS) Q9BUT1 (/TAS) Q9BUT1 (/TAS) Q9BUT1 (/TAS)
Heme metabolic process GO:0042168
The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
2 Q561X9 (/IMP) Q561X9 (/IMP)
Hemoglobin biosynthetic process GO:0042541
The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
2 Q561X9 (/IMP) Q561X9 (/IMP)
Erythrocyte maturation GO:0043249
A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state.
2 Q561X9 (/IMP) Q561X9 (/IMP)
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
1 Q8JZV9 (/ISO)
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
1 Q8JZV9 (/ISS)
Siderophore biosynthetic process GO:0019290
The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action.
1 Q8JZV9 (/IMP)
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
1 Q8JZV9 (/ISO)
Iron ion homeostasis GO:0055072
Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
1 Q8JZV9 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
10 A0A024RDG9 (/IDA) A0A024RDG9 (/IDA) A0A024RDG9 (/IDA) A0A024RDG9 (/IDA) A0A024RDG9 (/IDA) Q9BUT1 (/IDA) Q9BUT1 (/IDA) Q9BUT1 (/IDA) Q9BUT1 (/IDA) Q9BUT1 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 Q9BUT1 (/IDA) Q9BUT1 (/IDA) Q9BUT1 (/IDA) Q9BUT1 (/IDA) Q9BUT1 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 Q9BUT1 (/TAS) Q9BUT1 (/TAS) Q9BUT1 (/TAS) Q9BUT1 (/TAS) Q9BUT1 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
5 Q9BUT1 (/HDA) Q9BUT1 (/HDA) Q9BUT1 (/HDA) Q9BUT1 (/HDA) Q9BUT1 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8JZV9 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8JZV9 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8JZV9 (/ISO)
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