The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 191: Methylglyoxal reductase (NADPH-dependent)

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Carbonyl reductase (NADPH) activity GO:0004090
Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+.
8 P53111 (/IDA) P53111 (/IDA) P53183 (/IDA) P53183 (/IDA) P53183 (/IDA) P53183 (/IDA) P53183 (/IDA) P53183 (/IDA)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
6 P53183 (/IDA) P53183 (/IDA) P53183 (/IDA) P53183 (/IDA) P53183 (/IDA) P53183 (/IDA)
Oxidoreductase activity, acting on CH-OH group of donors GO:0016614
Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
6 P53183 (/IDA) P53183 (/IDA) P53183 (/IDA) P53183 (/IDA) P53183 (/IDA) P53183 (/IDA)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
2 P53111 (/IDA) P53111 (/IDA)
Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616
Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
2 P83775 (/IDA) P83775 (/IDA)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
1 A0A1D8PHQ6 (/NAS)
Aldehyde dehydrogenase (NADP+) activity GO:0033721
Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+.
1 Q03049 (/IDA)
Methylglyoxal reductase (NADPH-dependent) activity GO:0043892
Catalysis of the reaction: lactaldehyde + NADP+ = methylglyoxal + NADPH + H+.
1 Q12068 (/IDA)
Methylglyoxal reductase (NADPH-dependent) activity GO:0043892
Catalysis of the reaction: lactaldehyde + NADP+ = methylglyoxal + NADPH + H+.
1 Q9UT59 (/ISO)
3-methylbutanol:NAD(P) oxidoreductase activity GO:0046568
Catalysis of the reaction: 3-methylbutanol + NAD(P)+ = 3-methylbutanal + NAD(P)H + H+. 3-methylbutanal is also known as isovaleraldehyde.
1 Q12068 (/IMP)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to furfural GO:1901426
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a furfural stimulus.
7 P53183 (/IMP) P53183 (/IMP) P53183 (/IMP) P53183 (/IMP) P53183 (/IMP) P53183 (/IMP) Q03049 (/IMP)
Cellular aromatic compound metabolic process GO:0006725
The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
6 P53183 (/IDA) P53183 (/IDA) P53183 (/IDA) P53183 (/IDA) P53183 (/IDA) P53183 (/IDA)
Cellular ketone metabolic process GO:0042180
The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
6 P53183 (/IDA) P53183 (/IDA) P53183 (/IDA) P53183 (/IDA) P53183 (/IDA) P53183 (/IDA)
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
2 P83775 (/IDA) P83775 (/IDA)
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
2 P83775 (/IMP) P83775 (/IMP)
Methylglyoxal metabolic process GO:0009438
The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.
2 P83775 (/IDA) P83775 (/IDA)
Methylglyoxal metabolic process GO:0009438
The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.
2 P83775 (/IMP) P83775 (/IMP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
2 Q12068 (/IMP) Q59T49 (/IMP)
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
1 A0A1D8PHQ6 (/NAS)
Ergosterol metabolic process GO:0008204
The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light.
1 Q12068 (/IGI)
Ergosterol metabolic process GO:0008204
The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light.
1 Q12068 (/IMP)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 A0A1D8PHQ6 (/IEP)
Cellular detoxification of methylglyoxal GO:0140041
Any process carried out at the cellular level that reduces or removes the toxicity of methylglyoxal.
1 Q9UT59 (/IC)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 P53111 (/HDA) P53111 (/HDA) P53183 (/HDA) P53183 (/HDA) P53183 (/HDA) P53183 (/HDA) P53183 (/HDA) P53183 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P53111 (/HDA) P53111 (/HDA) Q9UT59 (/HDA)
Fungal biofilm matrix GO:0062040
An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses.
2 P83775 (/IDA) P83775 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q12068 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q12068 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9UT59 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q6FV31 (/IDA)
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