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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 185: peroxisomal multifunctional enzyme type 2

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Enoyl-CoA hydratase 2. [EC: 4.2.1.119]
(3R)-3-hydroxyacyl-CoA = (2E)-2-enoyl-CoA + H(2)O.
  • This enzyme catalyzes a hydration step in peroxisomal beta-oxidation.
  • The human multifunctional enzyme type 2 (MFE-2) is a 79000 Da enzyme composed of three functional units: (3R)-hydroxyacyl-CoA dehydrogenase, 2-enoyl-CoA hydratase 2 and sterol carrier protein 2-like units.
  • The enzymes from Aeromonas caviae and Arabidopsis thaliana are monofunctional enzymes.
  • 2-enoyl-CoA hydratase 3 from Candida tropicalis is a part from multifunctional enzyme type 2.
 23 A0A0S2Z4J1 A0A0S2Z4J1 A0A367YJG1 A0A367YJG1 C7GQF9 C7GQF9 C7GQF9 N1NZF4 N1NZF4 N1NZF4
(13 more...)
(3R)-hydroxyacyl-CoA dehydrogenase. [EC: 1.1.1.n12]
(R)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
    		 23 A0A0S2Z4J1 A0A0S2Z4J1 A0A367YJG1 A0A367YJG1 C7GQF9 C7GQF9 C7GQF9 N1NZF4 N1NZF4 N1NZF4
    (13 more...)
    3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase. [EC: 4.2.1.107]
    (24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestanoyl- CoA = (24E)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl- CoA + H(2)O.
    • Forms part of the rat peroxisomal multifunctional enzyme perMFE-2, which also exhibits a dehydrogenase activity.
    • Involved in the beta-oxidation of the cholesterol side chain in the cholic-acid biosynthesis pathway.
    		 6 A0A0S2Z4J1 A0A0S2Z4J1 P51659 P51659 P51660 P97852
    3-hydroxyacyl-CoA dehydrogenase. [EC: 1.1.1.35]
    (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
    • Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate.
    • Some enzymes act, more slowly, with NADP(+).
    • Broad specificity to acyl chain-length (cf. EC 1.1.1.211).
    		 1 Q9NKW1
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