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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 123: Fatty acyl-CoA reductase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Alcohol-forming fatty acyl-CoA reductase. [EC: 1.2.1.84]
A long-chain acyl-CoA + 2 NADPH = CoA + a long-chain alcohol + 2 NADP(+).
  • The enzyme has been characterized from the plant Simmondsia chinensis (jojoba).
  • The alcohol is formed by a four-electron reduction of fatty acyl-CoA.
  • Although the reaction proceeds through an aldehyde intermediate, a free aldehyde is not released.
  • The recombinant enzyme was shown to accept saturated and mono- unsaturated fatty acyl-CoAs of 16 to 22 carbons.
 15 A0A1L8GIY0 A0A1L8GIY0 A0A2J8UQ44 A0A2J8UQ44 Q5R834 Q5R834 Q5ZM72 Q5ZM72 Q66H50 Q7ZXF5
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