The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: Malate dehydrogenase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-malate dehydrogenase activity GO:0030060
Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.
20 F1C7I4 (/IDA) O88989 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA)
(10 more)
Malate dehydrogenase activity GO:0016615
Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate.
6 O88989 (/IDA) Q383F3 (/IDA) Q95WV4 (/IDA) Q95WV4 (/IDA) Q95WV4 (/IDA) Q9VKX2 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P40925 (/IPI) P40925 (/IPI) P57106 (/IPI) P93819 (/IPI) P93819 (/IPI)
L-malate dehydrogenase activity GO:0030060
Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.
3 A0A2R9YJL1 (/ISS) Q7ZSY2 (/ISS) Q801E6 (/ISS)
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
3 O88989 (/IDA) P11708 (/IDA) P11708 (/IDA)
Malic enzyme activity GO:0004470
Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
2 P40925 (/TAS) P40925 (/TAS)
Malate dehydrogenase activity GO:0016615
Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate.
1 P14152 (/ISO)
Malate dehydrogenase activity GO:0016615
Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate.
1 Q60B71 (/ISS)
L-malate dehydrogenase activity GO:0030060
Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.
1 P14152 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 F1C7I4 (/IDA)
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
1 P14152 (/ISO)
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
1 F1C7I4 (/ISS)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
12 P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA)
(2 more)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
12 P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA) P9WK13 (/IDA)
(2 more)
Malate metabolic process GO:0006108
The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
6 F1C7I4 (/IDA) O88989 (/IDA) Q383F3 (/IDA) Q95WV4 (/IDA) Q95WV4 (/IDA) Q95WV4 (/IDA)
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
2 P40925 (/TAS) P40925 (/TAS)
NADH metabolic process GO:0006734
The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.
2 F1C7I4 (/IDA) O88989 (/IDA)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
2 P93819 (/IEP) P93819 (/IEP)
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
2 P93819 (/IDA) P93819 (/IDA)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
2 P93819 (/IEP) P93819 (/IEP)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
2 P93819 (/IEP) P93819 (/IEP)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
1 Q60B71 (/ISS)
Oxaloacetate metabolic process GO:0006107
The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle.
1 O88989 (/IDA)
Oxaloacetate metabolic process GO:0006107
The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle.
1 P14152 (/ISO)
Malate metabolic process GO:0006108
The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
1 P14152 (/ISO)
NADH metabolic process GO:0006734
The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.
1 P14152 (/ISO)
NAD metabolic process GO:0019674
The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.
1 O88989 (/IDA)
NAD metabolic process GO:0019674
The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.
1 P14152 (/ISO)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 Q9VKX2 (/IDA)

There are 25 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
12 P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA)
(2 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
12 P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA)
(2 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
12 P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA) P9WK13 (/HDA)
(2 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
9 P11708 (/IDA) P11708 (/IDA) P57106 (/IDA) Q383F3 (/IDA) Q4Q7X6 (/IDA) Q95WV4 (/IDA) Q95WV4 (/IDA) Q95WV4 (/IDA) Q9VKX2 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 F1C7I4 (/IDA) Q383F3 (/IDA) Q95WV4 (/IDA) Q95WV4 (/IDA) Q95WV4 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 Q383F3 (/IDA) Q95WV4 (/IDA) Q95WV4 (/IDA) Q95WV4 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 P57106 (/IDA) P93819 (/IDA) P93819 (/IDA)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
3 P57106 (/IDA) P93819 (/IDA) P93819 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 P93819 (/IDA) P93819 (/IDA) Q9FJU0 (/IDA)
Apoplast GO:0048046
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
3 P57106 (/IDA) P93819 (/IDA) P93819 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P40925 (/HDA) P40925 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P93819 (/IDA) P93819 (/IDA)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
2 P93819 (/IDA) P93819 (/IDA)
Vacuolar membrane GO:0005774
The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
2 P93819 (/IDA) P93819 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
2 Q8MQS7 (/ISM) Q9VKX2 (/ISM)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P40925 (/TAS) P40925 (/TAS)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
2 P93819 (/IDA) P93819 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
2 P93819 (/IDA) P93819 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P40925 (/HDA) P40925 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q5ZME2 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P14152 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P14152 (/ISO)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
1 Q54D04 (/HDA)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
1 P14152 (/HDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 Q54D04 (/HDA)
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