View in Gene3D

CATH Superfamily 3.40.50.620

HUPs

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
HUPs
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 29: tRNA sulfurtransferase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
TRNA uracil 4-sulfurtransferase. [EC: 2.8.1.4]
ATP + [ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + uracil in tRNA + 2 reduced ferredoxin [iron-sulfur] cluster = AMP + diphosphate + 4-thiouracil in tRNA + [ThiI sulfur-carrier protein]-L-cysteine + 2 oxidized ferredoxin [iron-sulfur] cluster.
  • The enzyme, found in bacteria and archaea, is activated by EC 2.8.1.7, which transfers a sulfur atom to an internal L-cysteine residue, forming a cysteine persulfide.
  • The activated enzyme then transfers the sulfur to a uridine in a tRNA chain in a reaction that requires ATP.
  • The enzyme from the bacterium Escherichia coli forms 4-thiouridine only at position 8 of tRNA.
  • The enzyme also participates in the biosynthesis of the thiazole moiety of thiamine, but different domains are involved in the two processes.
 5881 A0A026V7E3 A0A026V7E3 A0A026V7E3 A0A026V7E3 A0A026V7E3 A0A026V7E3 A0A026V7E3 A0A026V7E3 A0A026V7E3 A0A026V7E3
(5871 more...)
CATH-Gene3D is a Global Biodata Core Resource Learn more...