The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"von Willebrand factor, type A domain
".
FunFam 12: Integrin, alpha 10
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 26 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Collagen binding involved in cell-matrix adhesion GO:0098639
Any collagen binding that occurs as part of cell-matrix adhesion.
|
6 | E9PXZ3 (/ISO) E9Q6R1 (/ISO) P61622 (/ISO) Q14BL5 (/ISO) Q3V3R4 (/ISO) Q62469 (/ISO) |
|
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
|
4 | A0A0G2K470 (/IMP) P17301 (/IMP) P18614 (/IMP) Q9UKX5 (/IMP) |
|
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
|
4 | O75578 (/TAS) P17301 (/TAS) P56199 (/TAS) Q9UKX5 (/TAS) |
|
Collagen binding involved in cell-matrix adhesion GO:0098639
Any collagen binding that occurs as part of cell-matrix adhesion.
|
4 | O75578 (/IMP) P17301 (/IMP) P56199 (/IMP) Q9UKX5 (/IMP) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | P17301 (/IPI) P56199 (/IPI) Q3V3R4 (/IPI) |
|
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
|
3 | P61622 (/ISO) Q3V3R4 (/ISO) Q62469 (/ISO) |
|
Collagen receptor activity GO:0038064
Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
2 | P17301 (/IMP) Q9UKX5 (/IMP) |
|
Collagen receptor activity GO:0038064
Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
2 | P61622 (/ISO) Q62469 (/ISO) |
|
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
|
1 | Q62469 (/IDA) |
|
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
|
1 | P17301 (/ISS) |
Showing 1 to 10 of 26 entries
There are 99 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
|
6 | E9PXZ3 (/ISO) E9Q6R1 (/ISO) P61622 (/ISO) Q14BL5 (/ISO) Q3V3R4 (/ISO) Q62469 (/ISO) |
|
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
5 | E9PXZ3 (/ISO) E9Q6R1 (/ISO) P61622 (/ISO) Q14BL5 (/ISO) Q62469 (/ISO) |
|
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
|
4 | O75578 (/IMP) P17301 (/IMP) P56199 (/IMP) Q9UKX5 (/IMP) |
|
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
|
4 | O75578 (/TAS) P17301 (/TAS) P56199 (/TAS) Q9UKX5 (/TAS) |
|
Substrate-dependent cell migration GO:0006929
The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate.
|
3 | P17301 (/IMP) P61622 (/IMP) Q9UKX5 (/IMP) |
|
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
|
3 | O75578 (/TAS) P17301 (/TAS) Q9UKX5 (/TAS) |
|
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
3 | O75578 (/IMP) P17301 (/IMP) Q9UKX5 (/IMP) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
3 | P18614 (/ISS) Q3V3R4 (/ISS) Q90615 (/ISS) |
|
Positive regulation of phosphoprotein phosphatase activity GO:0032516
Any process that activates or increases the activity of a phosphoprotein phosphatase.
|
3 | P18614 (/ISS) Q3V3R4 (/ISS) Q90615 (/ISS) |
|
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
|
3 | P18614 (/ISS) P56199 (/ISS) Q90615 (/ISS) |
Showing 1 to 10 of 99 entries
There are 43 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
6 | O75578 (/TAS) P17301 (/TAS) P56199 (/TAS) Q3V3R4 (/TAS) Q62469 (/TAS) Q9UKX5 (/TAS) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
5 | A0A0G2K470 (/IDA) P17301 (/IDA) P56199 (/IDA) Q3V3R4 (/IDA) Q62469 (/IDA) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
4 | A0A0G2K470 (/IDA) P17301 (/IDA) P56199 (/IDA) Q9UKX5 (/IDA) |
|
Integrin complex GO:0008305
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
|
4 | O75578 (/TAS) P17301 (/TAS) P56199 (/TAS) Q9UKX5 (/TAS) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
3 | P17301 (/HDA) P56199 (/HDA) Q9UKX5 (/HDA) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
3 | P61622 (/ISO) Q3V3R4 (/ISO) Q62469 (/ISO) |
|
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
3 | P18614 (/IDA) Q3V3R4 (/IDA) Q62469 (/IDA) |
|
Integrin alpha10-beta1 complex GO:0034680
An integrin complex that comprises one alpha10 subunit and one beta1 subunit.
|
3 | E9PXZ3 (/ISO) E9Q6R1 (/ISO) Q14BL5 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | A0A0G2K470 (/IDA) P17301 (/IDA) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
2 | P17301 (/HDA) P56199 (/HDA) |
Showing 1 to 10 of 43 entries
