The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 459: ras-related protein Rab-37 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 Q504M8 (/IPI) Q504M8 (/IPI) Q96AX2 (/IPI) Q96AX2 (/IPI) Q9JKM7 (/IPI) Q9ULW5 (/IPI) Q9ULW5 (/IPI) Q9ULW5 (/IPI)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
7 Q29RR0 (/ISS) Q29RR0 (/ISS) Q504M8 (/ISS) Q504M8 (/ISS) Q9ULW5 (/ISS) Q9ULW5 (/ISS) Q9ULW5 (/ISS)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
3 Q9ULW5 (/IMP) Q9ULW5 (/IMP) Q9ULW5 (/IMP)
GMP binding GO:0019002
Interacting selectively and non-covalently with GMP, guanosine monophosphate.
3 Q9ULW5 (/IMP) Q9ULW5 (/IMP) Q9ULW5 (/IMP)
GMP binding GO:0019002
Interacting selectively and non-covalently with GMP, guanosine monophosphate.
3 P51156 (/ISS) Q504M8 (/ISS) Q504M8 (/ISS)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
2 Q504M8 (/ISO) Q504M8 (/ISO)
GMP binding GO:0019002
Interacting selectively and non-covalently with GMP, guanosine monophosphate.
2 Q504M8 (/ISO) Q504M8 (/ISO)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
1 Q9JKM7 (/ISS)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
1 P51156 (/TAS)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 P51156 (/IDA)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 P51156 (/TAS)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of exocytosis GO:0017157
Any process that modulates the frequency, rate or extent of exocytosis.
7 Q29RR0 (/ISS) Q29RR0 (/ISS) Q504M8 (/ISS) Q504M8 (/ISS) Q9ULW5 (/ISS) Q9ULW5 (/ISS) Q9ULW5 (/ISS)
Exocrine system development GO:0035272
Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system.
7 Q29RR0 (/ISS) Q29RR0 (/ISS) Q504M8 (/ISS) Q504M8 (/ISS) Q9ULW5 (/ISS) Q9ULW5 (/ISS) Q9ULW5 (/ISS)
Exocrine system development GO:0035272
Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system.
3 Q9ULW5 (/IMP) Q9ULW5 (/IMP) Q9ULW5 (/IMP)
Golgi to plasma membrane protein transport GO:0043001
The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.
3 Q9ULW5 (/IMP) Q9ULW5 (/IMP) Q9ULW5 (/IMP)
Golgi to plasma membrane protein transport GO:0043001
The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.
3 P51156 (/ISS) Q504M8 (/ISS) Q504M8 (/ISS)
Regulated exocytosis GO:0045055
A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand.
3 Q9ULW5 (/IMP) Q9ULW5 (/IMP) Q9ULW5 (/IMP)
Regulated exocytosis GO:0045055
A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand.
3 P51156 (/ISS) Q504M8 (/ISS) Q504M8 (/ISS)
Regulation of protein catabolic process at presynapse, modulating synaptic transmission GO:0099575
Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse.
3 Q9ULW5 (/IDA) Q9ULW5 (/IDA) Q9ULW5 (/IDA)
Regulation of protein catabolic process at presynapse, modulating synaptic transmission GO:0099575
Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse.
3 Q9ULW5 (/IMP) Q9ULW5 (/IMP) Q9ULW5 (/IMP)
Regulation of exocytosis GO:0017157
Any process that modulates the frequency, rate or extent of exocytosis.
2 Q504M8 (/ISO) Q504M8 (/ISO)
Exocrine system development GO:0035272
Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system.
2 Q504M8 (/ISO) Q504M8 (/ISO)
Golgi to plasma membrane protein transport GO:0043001
The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.
2 Q504M8 (/ISO) Q504M8 (/ISO)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
2 Q96AX2 (/TAS) Q96AX2 (/TAS)
Regulated exocytosis GO:0045055
A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand.
2 Q504M8 (/ISO) Q504M8 (/ISO)
Regulation of protein catabolic process at presynapse, modulating synaptic transmission GO:0099575
Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse.
2 Q504M8 (/ISO) Q504M8 (/ISO)
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
1 P51156 (/TAS)
Regulation of exocytosis GO:0017157
Any process that modulates the frequency, rate or extent of exocytosis.
1 P51156 (/IDA)
Exocrine system development GO:0035272
Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system.
1 P51156 (/IDA)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
7 Q29RR0 (/ISS) Q29RR0 (/ISS) Q504M8 (/ISS) Q504M8 (/ISS) Q9ULW5 (/ISS) Q9ULW5 (/ISS) Q9ULW5 (/ISS)
Secretory granule membrane GO:0030667
The lipid bilayer surrounding a secretory granule.
4 P51156 (/ISS) Q9ULW5 (/ISS) Q9ULW5 (/ISS) Q9ULW5 (/ISS)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
3 Q9ULW5 (/IDA) Q9ULW5 (/IDA) Q9ULW5 (/IDA)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
3 P51156 (/ISS) Q504M8 (/ISS) Q504M8 (/ISS)
Anchored component of synaptic vesicle membrane GO:0098993
The component of the synaptic vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
3 Q9ULW5 (/IDA) Q9ULW5 (/IDA) Q9ULW5 (/IDA)
Anchored component of synaptic vesicle membrane GO:0098993
The component of the synaptic vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
3 Q9ULW5 (/IMP) Q9ULW5 (/IMP) Q9ULW5 (/IMP)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
2 Q504M8 (/ISO) Q504M8 (/ISO)
Endoplasmic reticulum-Golgi intermediate compartment GO:0005793
A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.
2 Q96AX2 (/IDA) Q96AX2 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q96AX2 (/TAS) Q96AX2 (/TAS)
Secretory granule membrane GO:0030667
The lipid bilayer surrounding a secretory granule.
2 Q504M8 (/IDA) Q504M8 (/IDA)
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
2 Q504M8 (/ISO) Q504M8 (/ISO)
Azurophil granule membrane GO:0035577
The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
2 Q96AX2 (/TAS) Q96AX2 (/TAS)
Specific granule membrane GO:0035579
The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
2 Q96AX2 (/TAS) Q96AX2 (/TAS)
Anchored component of synaptic vesicle membrane GO:0098993
The component of the synaptic vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
2 Q504M8 (/ISO) Q504M8 (/ISO)
Endoplasmic reticulum-Golgi intermediate compartment GO:0005793
A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.
1 Q9JKM7 (/ISO)
Secretory granule GO:0030141
A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
1 Q9JKM7 (/IDA)
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
1 P51156 (/IDA)
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