The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 254: U5 small nuclear ribonucleoprotein helicase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
12 O75643 (/IPI) O75643 (/IPI) O75643 (/IPI) O75643 (/IPI) O75643 (/IPI) O75643 (/IPI) O75643 (/IPI) O75643 (/IPI) O75643 (/IPI) P32639 (/IPI)
(2 more)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
11 O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) P32639 (/IDA)
(1 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
11 O75643 (/IPI) O75643 (/IPI) O75643 (/IPI) O75643 (/IPI) O75643 (/IPI) O75643 (/IPI) O75643 (/IPI) O75643 (/IPI) O75643 (/IPI) P32639 (/IPI)
(1 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
9 O75643 (/HDA) O75643 (/HDA) O75643 (/HDA) O75643 (/HDA) O75643 (/HDA) O75643 (/HDA) O75643 (/HDA) O75643 (/HDA) O75643 (/HDA)
Helicase activity GO:0004386
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
9 O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
6 F1LNJ2 (/ISS) P53327 (/ISS) P53327 (/ISS) P53327 (/ISS) Q6P4T2 (/ISS) Q9VUV9 (/ISS)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
3 P53327 (/HDA) P53327 (/HDA) P53327 (/HDA)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
2 P32639 (/IMP) P32639 (/IMP)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
2 Q6P4T2 (/ISO) Q9UT24 (/ISO)
Helicase activity GO:0004386
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
1 Q6P4T2 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q6P4T2 (/ISO)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
10 O75643 (/IC) O75643 (/IC) O75643 (/IC) O75643 (/IC) O75643 (/IC) O75643 (/IC) O75643 (/IC) O75643 (/IC) O75643 (/IC) Q9VUV9 (/IC)
Cis assembly of pre-catalytic spliceosome GO:0000354
Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner.
9 O75643 (/IC) O75643 (/IC) O75643 (/IC) O75643 (/IC) O75643 (/IC) O75643 (/IC) O75643 (/IC) O75643 (/IC) O75643 (/IC)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
9 O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
9 O75643 (/TAS) O75643 (/TAS) O75643 (/TAS) O75643 (/TAS) O75643 (/TAS) O75643 (/TAS) O75643 (/TAS) O75643 (/TAS) O75643 (/TAS)
Osteoblast differentiation GO:0001649
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
9 O75643 (/HDA) O75643 (/HDA) O75643 (/HDA) O75643 (/HDA) O75643 (/HDA) O75643 (/HDA) O75643 (/HDA) O75643 (/HDA) O75643 (/HDA)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
4 F1LNJ2 (/ISS) Q6P4T2 (/ISS) Q9U2G0 (/ISS) Q9VUV9 (/ISS)
Cytoplasmic translation GO:0002181
The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
3 P53327 (/IGI) P53327 (/IGI) P53327 (/IGI)
Regulation of translation GO:0006417
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
3 P53327 (/IMP) P53327 (/IMP) P53327 (/IMP)
Spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) GO:0000388
Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11).
2 P32639 (/IMP) P32639 (/IMP)
RNA splicing GO:0008380
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
2 Q55CI8 (/ISS) Q9VUV9 (/ISS)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
1 Q9VUV9 (/HMP)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
1 Q9VUV9 (/HMP)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
1 Q9VUV9 (/IMP)
Spliceosomal conformational changes to generate catalytic conformation GO:0000393
Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation.
1 Q9UT24 (/IGI)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
1 Q6P4T2 (/ISO)
MRNA processing GO:0006397
Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
1 Q9SYP1 (/IMP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 Q9VUV9 (/IMP)
Ventral cord development GO:0007419
The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.
1 Q9VUV9 (/HMP)
Vegetative to reproductive phase transition of meristem GO:0010228
The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence.
1 Q9SYP1 (/IMP)

There are 33 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
U5 snRNP GO:0005682
A ribonucleoprotein complex that contains small nuclear RNA U5.
12 O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) P32639 (/IDA)
(2 more)
U4/U6 x U5 tri-snRNP complex GO:0046540
A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins.
11 O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) P32639 (/IDA)
(1 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
10 O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) Q9VUV9 (/IDA)
Spliceosomal complex GO:0005681
Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.
10 O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) Q9UT24 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
9 O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
9 O75643 (/TAS) O75643 (/TAS) O75643 (/TAS) O75643 (/TAS) O75643 (/TAS) O75643 (/TAS) O75643 (/TAS) O75643 (/TAS) O75643 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
9 O75643 (/HDA) O75643 (/HDA) O75643 (/HDA) O75643 (/HDA) O75643 (/HDA) O75643 (/HDA) O75643 (/HDA) O75643 (/HDA) O75643 (/HDA)
U2-type precatalytic spliceosome GO:0071005
A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.
9 O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA)
U2-type catalytic step 1 spliceosome GO:0071006
A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs.
9 O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA)
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
9 O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA) O75643 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P32639 (/HDA) P32639 (/HDA) Q9UT24 (/HDA)
Spliceosomal complex GO:0005681
Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.
3 Q55CI8 (/ISS) Q9U2G0 (/ISS) Q9VUV9 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P53327 (/HDA) P53327 (/HDA) P53327 (/HDA)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
3 P53327 (/IDA) P53327 (/IDA) P53327 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 F1LNJ2 (/ISS) Q6P4T2 (/ISS)
U4/U6 x U5 tri-snRNP complex GO:0046540
A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins.
2 Q6P4T2 (/ISO) Q9UT24 (/ISO)
U2-type precatalytic spliceosome GO:0071005
A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.
2 F1LNJ2 (/ISS) Q6P4T2 (/ISS)
U2-type catalytic step 1 spliceosome GO:0071006
A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs.
2 F1LNJ2 (/ISS) Q6P4T2 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9VUV9 (/IC)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q6P4T2 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q6P4T2 (/ISO)
Spliceosomal complex GO:0005681
Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.
1 Q6P4T2 (/ISO)
U5 snRNP GO:0005682
A ribonucleoprotein complex that contains small nuclear RNA U5.
1 Q6P4T2 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q9SYP1 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9UT24 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9SYP1 (/IDA)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
1 O48534 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9SYP1 (/IDA)
Small nuclear ribonucleoprotein complex GO:0030532
A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs.
1 Q9VUV9 (/IPI)
Precatalytic spliceosome GO:0071011
A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs.
1 Q9VUV9 (/HDA)
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
1 Q9VUV9 (/HDA)
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
1 Q6P4T2 (/ISO)
Post-mRNA release spliceosomal complex GO:0071014
A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, including U5.
1 Q9UT24 (/IDA)
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