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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 249: tRNA modification GTPase MnmE

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
 51 P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA)
(41 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 51 P25522 (/IPI) P25522 (/IPI) P25522 (/IPI) P25522 (/IPI) P25522 (/IPI) P25522 (/IPI) P25522 (/IPI) P25522 (/IPI) P25522 (/IPI) P25522 (/IPI)
(41 more)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
 51 P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA)
(41 more)
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
 51 P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA)
(41 more)
Potassium ion binding GO:0030955
Interacting selectively and non-covalently with potassium (K+) ions.
 51 P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA)
(41 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 51 P25522 (/IPI) P25522 (/IPI) P25522 (/IPI) P25522 (/IPI) P25522 (/IPI) P25522 (/IPI) P25522 (/IPI) P25522 (/IPI) P25522 (/IPI) P25522 (/IPI)
(41 more)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
TRNA wobble uridine modification GO:0002098
The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.
 51 P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA)
(41 more)
TRNA wobble uridine modification GO:0002098
The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.
 51 P25522 (/IMP) P25522 (/IMP) P25522 (/IMP) P25522 (/IMP) P25522 (/IMP) P25522 (/IMP) P25522 (/IMP) P25522 (/IMP) P25522 (/IMP) P25522 (/IMP)
(41 more)
Response to pH GO:0009268
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
 51 P25522 (/IMP) P25522 (/IMP) P25522 (/IMP) P25522 (/IMP) P25522 (/IMP) P25522 (/IMP) P25522 (/IMP) P25522 (/IMP) P25522 (/IMP) P25522 (/IMP)
(41 more)
TRNA methylation GO:0030488
The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.
 51 P25522 (/IMP) P25522 (/IMP) P25522 (/IMP) P25522 (/IMP) P25522 (/IMP) P25522 (/IMP) P25522 (/IMP) P25522 (/IMP) P25522 (/IMP) P25522 (/IMP)
(41 more)
Chaperone-mediated protein folding GO:0061077
The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone.
 51 P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA)
(41 more)
TRNA modification GO:0006400
The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.
 4 Q9KVY5 (/ISS) Q9KVY5 (/ISS) Q9KVY5 (/ISS) Q9KVY5 (/ISS)
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
 4 Q9KVY5 (/ISS) Q9KVY5 (/ISS) Q9KVY5 (/ISS) Q9KVY5 (/ISS)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 51 P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA)
(41 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 51 P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA)
(41 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
 51 P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA) P25522 (/IDA)
(41 more)
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