The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 108: ATP-dependent RNA helicase RhlE

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
164 P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA)
(154 more)
RNA helicase activity GO:0003724
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.
137 A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS)
(127 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
131 A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS)
(121 more)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
131 A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS)
(121 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
87 P0A9P6 (/IPI) P0A9P6 (/IPI) P0A9P6 (/IPI) P0A9P6 (/IPI) P0A9P6 (/IPI) P0A9P6 (/IPI) P0A9P6 (/IPI) P0A9P6 (/IPI) P0A9P6 (/IPI) P0A9P6 (/IPI)
(77 more)
RNA strand annealing activity GO:0033592
Facilitates the base-pairing of complementary single-stranded RNA.
81 P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA)
(71 more)
Helicase activity GO:0004386
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
36 Q3ZA18 (/ISS) Q48DS1 (/ISS) Q48DS1 (/ISS) Q48DS1 (/ISS) Q48DS1 (/ISS) Q48DS1 (/ISS) Q48DS1 (/ISS) Q48DS1 (/ISS) Q48DS1 (/ISS) Q48DS1 (/ISS)
(26 more)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
33 P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA)
(23 more)
3'-5' RNA helicase activity GO:0034458
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix in the direction 3' to 5'.
27 P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA)
(17 more)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
25 P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA)
(15 more)
RRNA binding GO:0019843
Interacting selectively and non-covalently with ribosomal RNA.
25 P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA)
(15 more)
DNA/RNA helicase activity GO:0033677
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA.
25 P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA)
(15 more)
ADP binding GO:0043531
Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate.
25 P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA) P21693 (/IDA)
(15 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
8 P96614 (/IDA) P96614 (/IDA) P96614 (/IDA) P96614 (/IDA) P96614 (/IDA) P96614 (/IDA) P96614 (/IDA) P96614 (/IDA)
5'-3' RNA helicase activity GO:0032574
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix in the direction 5' to 3'.
2 Q55804 (/IDA) Q55804 (/IDA)
RNA strand-exchange activity GO:0034057
Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity.
2 Q55804 (/IDA) Q55804 (/IDA)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ribosomal large subunit assembly GO:0000027
The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.
104 P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP)
(94 more)
RNA catabolic process GO:0006401
The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
79 P0A9P6 (/IGI) P0A9P6 (/IGI) P0A9P6 (/IGI) P0A9P6 (/IGI) P0A9P6 (/IGI) P0A9P6 (/IGI) P0A9P6 (/IGI) P0A9P6 (/IGI) P0A9P6 (/IGI) P0A9P6 (/IGI)
(69 more)
Response to radiation GO:0009314
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.
79 P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP)
(69 more)
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
79 P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP)
(69 more)
MRNA stabilization GO:0048255
Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules.
79 P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP)
(69 more)
Cellular response to cold GO:0070417
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
79 P0A9P6 (/IEP) P0A9P6 (/IEP) P0A9P6 (/IEP) P0A9P6 (/IEP) P0A9P6 (/IEP) P0A9P6 (/IEP) P0A9P6 (/IEP) P0A9P6 (/IEP) P0A9P6 (/IEP) P0A9P6 (/IEP)
(69 more)
Cellular response to cold GO:0070417
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
79 P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP) P0A9P6 (/IMP)
(69 more)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
52 P25888 (/IMP) P25888 (/IMP) P25888 (/IMP) P25888 (/IMP) P25888 (/IMP) P25888 (/IMP) P25888 (/IMP) P25888 (/IMP) P25888 (/IMP) P25888 (/IMP)
(42 more)
Ribosome assembly GO:0042255
The aggregation, arrangement and bonding together of the mature ribosome and of its subunits.
52 P25888 (/IGI) P25888 (/IGI) P25888 (/IGI) P25888 (/IGI) P25888 (/IGI) P25888 (/IGI) P25888 (/IGI) P25888 (/IGI) P25888 (/IGI) P25888 (/IGI)
(42 more)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
8 P96614 (/IGI) P96614 (/IGI) P96614 (/IGI) P96614 (/IGI) P96614 (/IGI) P96614 (/IGI) P96614 (/IGI) P96614 (/IGI)
RNA secondary structure unwinding GO:0010501
The process in which a secondary structure of RNA are broken or 'melted'.
8 P96614 (/IDA) P96614 (/IDA) P96614 (/IDA) P96614 (/IDA) P96614 (/IDA) P96614 (/IDA) P96614 (/IDA) P96614 (/IDA)
RNA metabolic process GO:0016070
The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
6 Q74GQ7 (/ISS) Q74GQ7 (/ISS) Q9KLE2 (/ISS) Q9KLE2 (/ISS) Q9KLE2 (/ISS) Q9KLE2 (/ISS)
Single-species biofilm formation GO:0044010
A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
4 Q9I689 (/IMP) Q9I689 (/IMP) Q9I689 (/IMP) Q9I689 (/IMP)
Bacterial-type flagellum-dependent swarming motility GO:0071978
Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.
4 Q9I689 (/IMP) Q9I689 (/IMP) Q9I689 (/IMP) Q9I689 (/IMP)
Ribosome biogenesis GO:0042254
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
2 Q74GQ7 (/ISS) Q74GQ7 (/ISS)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
131 P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA) P0A9P6 (/IDA)
(121 more)
Bacterial nucleoid GO:0043590
The region of a bacterial cell to which the DNA is confined.
131 A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS) A0R8U6 (/ISS)
(121 more)
Bacterial nucleoid GO:0043590
The region of a bacterial cell to which the DNA is confined.
8 P96614 (/IDA) P96614 (/IDA) P96614 (/IDA) P96614 (/IDA) P96614 (/IDA) P96614 (/IDA) P96614 (/IDA) P96614 (/IDA)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
5 P9WH05 (/HDA) P9WH05 (/HDA) P9WH05 (/HDA) P9WH05 (/HDA) P9WH05 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P9WH05 (/HDA) P9WH05 (/HDA) P9WH05 (/HDA) P9WH05 (/HDA) P9WH05 (/HDA)
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