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CATH Superfamily 3.40.50.1970

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 36: Glycerol-1-phosphate dehydrogenase [NAD(P)+]

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Sn-glycerol-1-phosphate dehydrogenase. [EC: 1.1.1.261]
sn-glycerol 1-phosphate + NAD(P)(+) = glycerone phosphate + NAD(P)H.
  • Responsible for the formation of archaea-specific sn-glycerol-1- phosphate, the first step in the biosynthesis of polar lipids in archaea.
  • It is the enantiomer of sn-glycerol 3-phosphate, the form of glycerophosphate found in bacteria and eukaryotes.
  • The other enzymes involved in the biosynthesis of polar lipids in archaea are EC 2.5.1.41 and EC 2.5.1.42, which together alkylate the hydroxy groups of glycerol 1-phosphate to give unsaturated archaetidic acid, which is acted upon by EC 2.7.7.67 to form CDP- unsaturated archaeol.
  • The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine.
  • Activity of the enzyme is stimulated by K(+).
 25 A0A162S197 A0A162S197 A0A162S197 A0A162S197 A0A162S197 A0A1D8FKX3 A0A1D8FKX3 A0A1D8FKX3 A0A1D8FKX3 A0A1D8FKX3
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