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CATH Superfamily 3.40.50.1970

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: NDMA-dependent methanol dehydrogenase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Methanol dehydrogenase (nicotinoprotein). [EC: 1.1.99.37]
Methanol + acceptor = formaldehyde + reduced acceptor.
  • Nicotinoprotein methanol dehydrogenases have a tightly bound NADP+/NADPH cofactor that does not dissociate during the catalytic process.
  • Instead, the cofactor is regenerated by a second substrate or electron carrier.
  • While the in vivo electron acceptor is not known, N,N-dimethyl-4- nitrosoaniline (NDMA) can serve this function in vitro.
  • The enzyme has been detected in several Gram-positive methylotrophic bacteria, including Amycolatopsis methanolica, Rhodococcus rhodochrous and Rhodococcus erythropolis.
  • These enzymes are decameric, and possess a 5-fold symmetry.
  • Some of the enzymes can also dismutate formaldehyde to methanol and formate.
 11 A0A1Q4TVU7 A0A1Q4TVU7 A0A1Q4TVU7 C5MRT8 C5MRT8 C5MRT8 Q53062 Q9RCG0 X5KSS9 X5KSS9
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