The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
alpha/beta hydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 82: monoacylglycerol lipase ABHD6

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Acylglycerol lipase activity GO:0047372
Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol.
5 Q8R2Y0 (/IDA) Q9BV23 (/IDA) Q9BV23 (/IDA) Q9BV23 (/IDA) Q9BV23 (/IDA)
Acylglycerol lipase activity GO:0047372
Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol.
5 Q1LZ86 (/ISS) Q1LZ86 (/ISS) Q5XI64 (/ISS) Q6GLL2 (/ISS) Q7SY73 (/ISS)
Phospholipase activity GO:0004620
Catalysis of the hydrolysis of a glycerophospholipid.
1 Q8R2Y0 (/IDA)
Acylglycerol lipase activity GO:0047372
Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol.
1 Q8R2Y0 (/IMP)
Acylglycerol lipase activity GO:0047372
Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol.
1 Q8R2Y0 (/ISO)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Monoacylglycerol catabolic process GO:0052651
The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified.
9 Q1LZ86 (/ISS) Q1LZ86 (/ISS) Q5XI64 (/ISS) Q6GLL2 (/ISS) Q7SY73 (/ISS) Q9BV23 (/ISS) Q9BV23 (/ISS) Q9BV23 (/ISS) Q9BV23 (/ISS)
Lysobisphosphatidic acid metabolic process GO:2001311
The chemical reactions and pathways involving a lysobisphosphatidic acid. A lysobisphosphatidic acid is a lysophosphatidic acid having the unusual property of a phosphodiester moiety linked to positions sn-1 and sn1' of glycerol; and two additional fatty acids esterified to the glycerol head group.
9 Q1LZ86 (/ISS) Q1LZ86 (/ISS) Q5XI64 (/ISS) Q6GLL2 (/ISS) Q7SY73 (/ISS) Q9BV23 (/ISS) Q9BV23 (/ISS) Q9BV23 (/ISS) Q9BV23 (/ISS)
Acylglycerol catabolic process GO:0046464
The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.
5 Q8R2Y0 (/IDA) Q9BV23 (/IDA) Q9BV23 (/IDA) Q9BV23 (/IDA) Q9BV23 (/IDA)
Acylglycerol catabolic process GO:0046464
The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.
5 Q1LZ86 (/ISS) Q1LZ86 (/ISS) Q5XI64 (/ISS) Q6GLL2 (/ISS) Q7SY73 (/ISS)
Negative regulation of cold-induced thermogenesis GO:0120163
Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
5 Q5XI64 (/ISS) Q9BV23 (/ISS) Q9BV23 (/ISS) Q9BV23 (/ISS) Q9BV23 (/ISS)
Phospholipid catabolic process GO:0009395
The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
1 Q8R2Y0 (/IDA)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
1 Q8R2Y0 (/IMP)
Acylglycerol catabolic process GO:0046464
The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.
1 Q8R2Y0 (/ISO)
Positive regulation of lipid biosynthetic process GO:0046889
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
1 Q8R2Y0 (/IMP)
Monoacylglycerol catabolic process GO:0052651
The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified.
1 Q8R2Y0 (/IDA)
Long-term synaptic depression GO:0060292
A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse.
1 Q8R2Y0 (/IMP)
Regulation of retrograde trans-synaptic signaling by endocanabinoid GO:0099178
Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by an endocannabinoid.
1 Q8R2Y0 (/EXP)
Negative regulation of cold-induced thermogenesis GO:0120163
Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
1 Q8R2Y0 (/IMP)
Regulation of endocannabinoid signaling pathway GO:2000124
Any process that modulates the frequency, rate or extent of endocannabinoid signaling pathway.
1 Q8R2Y0 (/IMP)
Lysobisphosphatidic acid metabolic process GO:2001311
The chemical reactions and pathways involving a lysobisphosphatidic acid. A lysobisphosphatidic acid is a lysophosphatidic acid having the unusual property of a phosphodiester moiety linked to positions sn-1 and sn1' of glycerol; and two additional fatty acids esterified to the glycerol head group.
1 Q8R2Y0 (/IDA)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
9 Q1LZ86 (/ISS) Q1LZ86 (/ISS) Q5XI64 (/ISS) Q6GLL2 (/ISS) Q7SY73 (/ISS) Q9BV23 (/ISS) Q9BV23 (/ISS) Q9BV23 (/ISS) Q9BV23 (/ISS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
9 Q1LZ86 (/ISS) Q1LZ86 (/ISS) Q5XI64 (/ISS) Q6GLL2 (/ISS) Q7SY73 (/ISS) Q9BV23 (/ISS) Q9BV23 (/ISS) Q9BV23 (/ISS) Q9BV23 (/ISS)
Late endosome membrane GO:0031902
The lipid bilayer surrounding a late endosome.
9 Q1LZ86 (/ISS) Q1LZ86 (/ISS) Q5XI64 (/ISS) Q6GLL2 (/ISS) Q7SY73 (/ISS) Q9BV23 (/ISS) Q9BV23 (/ISS) Q9BV23 (/ISS) Q9BV23 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 Q9BV23 (/TAS) Q9BV23 (/TAS) Q9BV23 (/TAS) Q9BV23 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8R2Y0 (/IDA)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
1 Q8R2Y0 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q8R2Y0 (/IDA)
Late endosome membrane GO:0031902
The lipid bilayer surrounding a late endosome.
1 Q8R2Y0 (/IDA)
AMPA glutamate receptor complex GO:0032281
An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus.
1 Q8R2Y0 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q8R2Y0 (/EXP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q8R2Y0 (/IDA)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
1 Q8R2Y0 (/IDA)
Integral component of postsynaptic membrane GO:0099055
The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q8R2Y0 (/IDA)
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