The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
alpha/beta hydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1352: Dihydromonacolin L-[lovastatin nonaketide synthase...

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase. [EC: 3.1.2.31]
Dihydromonacolin L-[lovastatin nonaketide synthase] + H(2)O = holo- [lovastatin nonaketide synthase] + dihydromonacolin L acid.
  • Dihydromonacolin L acid is synthesized while bound to an acyl-carrier protein domain of EC 2.3.1.161.
  • Since that enzyme lacks a thioesterase domain, release of the dihydromonacolin L acid moiety from the polyketide synthase requires this dedicated enzyme.
1 Q0C8M2
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