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CATH Superfamily 3.40.50.150

Vaccinia Virus protein VP39

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 206: O-methyltransferase ZRP4

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase. [EC: 2.1.1.212]
S-adenosyl-L-methionine + 2,4',7-trihydroxyisoflavanone = S-adenosyl-L- homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone.
  • Specifically methylates 2,4',7-trihydroxyisoflavanone on the 4'-position.
  • No activity with isoflavones.
  • The enzyme is involved in formononetin biosynthesis in legumes.
  • The protein from pea (Pisum sativum) also methylates (+)- 6a-hydroxymaackiain at the 3-position (cf. EC 2.1.1.270).
 5 I3RZV3 I3RZV3 Q84KK4 Q84KK4 Q84KK6
Isoflavone 4'-O-methyltransferase. [EC: 2.1.1.46]
S-adenosyl-L-methionine + a 4'-hydroxyisoflavone = S-adenosyl-L- homocysteine + a 4'-methoxyisoflavone.
  • The enzyme catalyzes the methylation of daidzein and genistein.
  • It does not methylate naringenin, apigenin, luteolin or kaempferol.
 5 I3RZV3 I3RZV3 Q84KK4 Q84KK4 Q84KK6
2,4,7-trihydroxy-1,4-benzoxazin-3-one-glucoside 7-O-methyltransferase. [EC: 2.1.1.241]
S-adenosyl-L-methionine + (2R)-4,7-dihydroxy-3-oxo-3,4-dihydro-2H-1,4- benzoxazin-2-yl beta-D-glucopyranoside = S-adenosyl-L-homocysteine + (2R)-4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D- glucopyranoside.
  • The enzyme is involved in the biosynthesis of the protective and allelophatic benzoxazinoid DIMBOA ((2R)-4-hydroxy-7-methoxy-3-oxo- 3,4-dihydro-2H-1,4-benzoxazin) in some plants, most commonly from the family of Poacea (grasses).
 1 B1P123
8-hydroxyquercetin 8-O-methyltransferase. [EC: 2.1.1.88]
S-adenosyl-L-methionine + 3,3',4',5,7,8-hexahydroxyflavone = S-adenosyl- L-homocysteine + 3,3',4',5,7-pentahydroxy-8-methoxyflavone.
  • Also acts on 8-hydroxykaempferol, but not on the glycosides of 8-hydroxyflavonols.
  • An enzyme from the flower buds of Lotus corniculatus.
 1 Q6VMW0
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