The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
N-terminal domain of ligase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Long-chain-fatty-acid--CoA ligase FadD

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 20 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Long-chain fatty acid-CoA ligase activity GO:0004467
Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
54 P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA)
(44 more)
Long-chain fatty acid-CoA ligase activity GO:0004467
Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
52 P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP)
(42 more)
Fatty acid binding GO:0005504
Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
52 P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP)
(42 more)
Oleic acid binding GO:0070538
Interacting selectively and non-covalently with oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid.
52 P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP)
(42 more)
Long-chain fatty acid-CoA ligase activity GO:0004467
Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
9 Q9KQL3 (/ISS) Q9KQL3 (/ISS) Q9KQL3 (/ISS) Q9KQL3 (/ISS) Q9KQL3 (/ISS) Q9KQL3 (/ISS) Q9KQL3 (/ISS) Q9KQL3 (/ISS) Q9KQL3 (/ISS)
4-coumarate-CoA ligase activity GO:0016207
Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA.
7 Q42524 (/IDA) Q42524 (/IDA) Q42524 (/IDA) Q9LU36 (/IDA) Q9S725 (/IDA) Q9S725 (/IDA) Q9S777 (/IDA)
Butyrate-CoA ligase activity GO:0047760
Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA.
4 A4YDR9 (/IDA) A4YDR9 (/IDA) Q8VZF1 (/IDA) Q9C8D4 (/IDA)
Acetate-CoA ligase activity GO:0003987
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
3 A4YDR9 (/IDA) A4YDR9 (/IDA) Q8VZF1 (/IDA)
Acyl-CoA ligase activity GO:0003996
Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain carboxylic acids have chain lengths of C13 to C22.
2 Q5LRT0 (/ISS) Q74GL7 (/ISS)
Fatty-acyl-CoA synthase activity GO:0004321
Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+.
2 Q84P23 (/IDA) Q9M0X9 (/IDA)
Phenylacetate-CoA ligase activity GO:0047475
Catalysis of the reaction: ATP + CoA + phenylacetate = AMP + diphosphate + H(+) + phenylacetyl-CoA.
2 D3GE78 (/IMP) D3GE78 (/IMP)
Propionate-CoA ligase activity GO:0050218
Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA.
2 A4YDR9 (/IDA) A4YDR9 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q9LQ12 (/IPI)
Fatty acid ligase activity GO:0015645
Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP.
1 Q9VMR6 (/TAS)
4-coumarate-CoA ligase activity GO:0016207
Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA.
1 Q5LVA1 (/ISS)
CoA-ligase activity GO:0016405
Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA.
1 Q84P24 (/IDA)
CoA-ligase activity GO:0016405
Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA.
1 Q9VMR6 (/TAS)
Acid-thiol ligase activity GO:0016878
Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
1 Q5LRT0 (/IDA)
Benzoate-CoA ligase activity GO:0018858
Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate + H(+).
1 Q9SS01 (/IDA)
Medium-chain fatty acid-CoA ligase activity GO:0031956
Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a medium-chain fatty acid is any fatty acid with a chain length of between C6 and C12.
1 Q9LQ12 (/IDA)

There are 33 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
52 P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP)
(42 more)
Fatty acid metabolic process GO:0006631
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
52 P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP)
(42 more)
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
52 P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA)
(42 more)
Acyl-CoA metabolic process GO:0006637
The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.
52 P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA)
(42 more)
Phospholipid biosynthetic process GO:0008654
The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
52 P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP)
(42 more)
Response to UV GO:0009411
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
52 P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP) P69451 (/IMP)
(42 more)
Fatty acid metabolic process GO:0006631
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
11 Q5LRT0 (/ISS) Q74GL7 (/ISS) Q9KQL3 (/ISS) Q9KQL3 (/ISS) Q9KQL3 (/ISS) Q9KQL3 (/ISS) Q9KQL3 (/ISS) Q9KQL3 (/ISS) Q9KQL3 (/ISS) Q9KQL3 (/ISS)
(1 more)
Phenylpropanoid metabolic process GO:0009698
The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid.
6 Q42524 (/TAS) Q42524 (/TAS) Q42524 (/TAS) Q9S725 (/TAS) Q9S725 (/TAS) Q9S777 (/TAS)
Ergosterol biosynthetic process GO:0006696
The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.
2 Q4WR83 (/IMP) Q4WR83 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
2 Q4WR83 (/IMP) Q4WR83 (/IMP)
Jasmonic acid biosynthetic process GO:0009695
The chemical reactions and pathways resulting in the formation of jasmonic acid, a fatty acid derivative.
2 Q84P23 (/IDA) Q9M0X9 (/IDA)
Cellular response to iron ion starvation GO:0010106
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions.
2 Q4WR83 (/IMP) Q4WR83 (/IMP)
Butyrate metabolic process GO:0019605
The chemical reactions and pathways involving any butyrate, the anions of butyric acid (butanoic acid), a saturated, unbranched aliphatic acid.
2 Q8VZF1 (/IDA) Q9C8D4 (/IDA)
Ferricrocin biosynthetic process GO:0031171
The chemical reactions and pathways resulting in the formation of ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3.
2 Q4WR83 (/IMP) Q4WR83 (/IMP)
Fatty-acyl-CoA biosynthetic process GO:0046949
The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group.
2 Q9LQ12 (/IDA) Q9VXZ8 (/IDA)
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
2 Q4WR83 (/IMP) Q4WR83 (/IMP)
N',N'',N'''-triacetylfusarinine C biosynthetic process GO:1900551
The chemical reactions and pathways resulting in the formation of N',N'',N'''-triacetylfusarinine C.
2 Q4WR83 (/IMP) Q4WR83 (/IMP)
Long-chain fatty acid metabolic process GO:0001676
The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
1 Q9VXZ8 (/IDA)
Acetate metabolic process GO:0006083
The chemical reactions and pathways involving acetate, the anion of acetic acid.
1 Q8VZF1 (/IDA)
Glyoxylate cycle GO:0006097
A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
1 Q8VZF1 (/IDA)
Fatty acid metabolic process GO:0006631
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
1 O18693 (/IGI)
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
1 Q9VMR6 (/TAS)
Ubiquinone biosynthetic process GO:0006744
The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
1 Q84P24 (/IMP)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
1 Q84P21 (/IEP)
Jasmonic acid biosynthetic process GO:0009695
The chemical reactions and pathways resulting in the formation of jasmonic acid, a fatty acid derivative.
1 Q84P21 (/IMP)
Phenylpropanoid metabolic process GO:0009698
The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid.
1 Q5LVA1 (/ISS)
Phenylpropanoid biosynthetic process GO:0009699
The chemical reactions and pathways resulting in the formation of aromatic derivatives of trans-cinnamic acid.
1 Q9LU36 (/IDA)
Pollen exine formation GO:0010584
The formation of the pollen exine. The reticulate pollen wall pattern consists of two layers, exine and intine.
1 Q9S777 (/IMP)
Triglyceride catabolic process GO:0019433
The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol.
1 Q9VXZ8 (/IDA)
Glucosinolate biosynthetic process GO:0019761
The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae.
1 Q9SS01 (/IMP)
Establishment or maintenance of epithelial cell apical/basal polarity GO:0045197
Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
1 Q9UAV8 (/IMP)
Sporopollenin biosynthetic process GO:0080110
The chemical reactions and pathways resulting in the formation of sporopollenin, a primary constituent of the pollen exine layer.
1 Q9LQ12 (/IMP)
Sporopollenin biosynthetic process GO:0080110
The chemical reactions and pathways resulting in the formation of sporopollenin, a primary constituent of the pollen exine layer.
1 Q9LQ12 (/TAS)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
56 P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA) P69451 (/IDA)
(46 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
52 P69451 (/TAS) P69451 (/TAS) P69451 (/TAS) P69451 (/TAS) P69451 (/TAS) P69451 (/TAS) P69451 (/TAS) P69451 (/TAS) P69451 (/TAS) P69451 (/TAS)
(42 more)
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
52 P69451 (/TAS) P69451 (/TAS) P69451 (/TAS) P69451 (/TAS) P69451 (/TAS) P69451 (/TAS) P69451 (/TAS) P69451 (/TAS) P69451 (/TAS) P69451 (/TAS)
(42 more)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
10 F4HUK6 (/IDA) Q4WR83 (/IDA) Q4WR83 (/IDA) Q84P21 (/IDA) Q84P23 (/IDA) Q84P24 (/IDA) Q8VZF1 (/IDA) Q9FFE6 (/IDA) Q9M0X9 (/IDA) Q9SS01 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 O18693 (/IDA) Q9VXZ8 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8VCW8 (/HDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
1 Q9VMR6 (/ISM)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
1 Q9SS01 (/ISS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q9LQ12 (/IDA)
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