The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
N-terminal domain of ligase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 18: Fatty acyl CoA synthetase 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fatty-acyl-CoA synthase activity GO:0004321
Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+.
18 Q38FB7 (/IDA) Q38FB7 (/IDA) Q38FB8 (/IDA) Q38FB8 (/IDA) Q38FB9 (/IDA) Q38FB9 (/IDA) Q38FB9 (/IDA) Q38FC0 (/IDA) Q38FC0 (/IDA) Q9U401 (/IDA)
(8 more)
Long-chain fatty acid-CoA ligase activity GO:0004467
Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
10 O22898 (/IDA) Q2I823 (/IDA) Q2I824 (/IDA) Q8LKS5 (/IDA) Q8LPS1 (/IDA) Q9C7W4 (/IDA) Q9T009 (/IDA) Q9T0A0 (/IDA) Q9XIA9 (/IDA) Q9XIA9 (/IDA)
Long-chain fatty acid-CoA ligase activity GO:0004467
Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
3 Q55DR6 (/TAS) Q8LKS5 (/TAS) Q8LPS1 (/TAS)
Very long-chain fatty acid-CoA ligase activity GO:0031957
Catalysis of the reaction: ATP + a very-long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a very long-chain fatty acid is a fatty acid which has a chain length greater than C22.
3 O22898 (/IDA) Q9XIA9 (/IDA) Q9XIA9 (/IDA)
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
1 Q38BS1 (/ISM)
Long-chain fatty acid-CoA ligase activity GO:0004467
Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
1 Q1ZXQ4 (/IMP)
Long-chain fatty acid-CoA ligase activity GO:0004467
Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
1 Q38BS1 (/ISA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q8LKS5 (/IPI)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fatty acid metabolic process GO:0006631
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
18 Q38FB7 (/IDA) Q38FB7 (/IDA) Q38FB8 (/IDA) Q38FB8 (/IDA) Q38FB9 (/IDA) Q38FB9 (/IDA) Q38FB9 (/IDA) Q38FC0 (/IDA) Q38FC0 (/IDA) Q9U401 (/IDA)
(8 more)
Fatty acid metabolic process GO:0006631
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
8 O22898 (/TAS) Q8LKS5 (/TAS) Q8LPS1 (/TAS) Q9C7W4 (/TAS) Q9T009 (/TAS) Q9T0A0 (/TAS) Q9XIA9 (/TAS) Q9XIA9 (/TAS)
Cutin biosynthetic process GO:0010143
The chemical reactions and pathways resulting in the formation of cutin, a waxy substance, which combined with cellulose forms a substance nearly impervious to water and constituting the cuticle in plants.
3 O22898 (/IMP) Q9XIA9 (/IMP) Q9XIA9 (/IMP)
Response to ozone GO:0010193
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus.
2 Q8LKS5 (/IEP) Q8LPS1 (/IEP)
Lateral root formation GO:0010311
The process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts. A lateral root primordium represents an organized group of cells derived from the root pericycle that will differentiate into a new root, as opposed to the initiation of the main root from the embryo proper.
2 Q9XIA9 (/IMP) Q9XIA9 (/IMP)
Anther development GO:0048653
The process whose specific outcome is the progression of the anther over time, from its formation to the mature structure.
2 Q2I823 (/IEP) Q2I824 (/IEP)
Defense response to fungus GO:0050832
Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
2 Q9XIA9 (/IMP) Q9XIA9 (/IMP)
Fatty acid metabolic process GO:0006631
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
1 Q55DR6 (/IMP)
Fatty acid metabolic process GO:0006631
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
1 Q1ZXQ4 (/ISS)
Microsporogenesis GO:0009556
The process in which the microsporocyte undergoes meiosis, giving rise to four haploid microspores.
1 Q2I824 (/IMP)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
1 Q8LKS5 (/IEP)
Wax biosynthetic process GO:0010025
The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids.
1 O22898 (/IMP)
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
1 Q1ZXQ4 (/IMP)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
18 Q38FB7 (/TAS) Q38FB7 (/TAS) Q38FB8 (/TAS) Q38FB8 (/TAS) Q38FB9 (/TAS) Q38FB9 (/TAS) Q38FB9 (/TAS) Q38FC0 (/TAS) Q38FC0 (/TAS) Q9U401 (/TAS)
(8 more)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
11 O22898 (/IDA) Q1ZXQ4 (/IDA) Q38FB9 (/IDA) Q38FB9 (/IDA) Q38FB9 (/IDA) Q9C7W4 (/IDA) Q9U403 (/IDA) Q9U403 (/IDA) Q9U403 (/IDA) Q9XIA9 (/IDA)
(1 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 Q38BS1 (/IDA) Q38FB8 (/IDA) Q38FB8 (/IDA) Q38FC0 (/IDA) Q38FC0 (/IDA) Q55DR6 (/IDA) Q9U402 (/IDA) Q9U402 (/IDA) Q9U404 (/IDA) Q9U404 (/IDA)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
8 Q38FB7 (/IDA) Q38FB7 (/IDA) Q38FC0 (/IDA) Q38FC0 (/IDA) Q9U401 (/IDA) Q9U401 (/IDA) Q9U404 (/IDA) Q9U404 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 Q38BS1 (/IDA) Q38FB8 (/IDA) Q38FB8 (/IDA) Q9U402 (/IDA) Q9U402 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 E9AC38 (/ISO) E9AC40 (/ISO) E9AC41 (/ISO) E9AC43 (/ISO) E9ACH0 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 E9AC38 (/ISO) E9AC40 (/ISO) E9AC41 (/ISO) E9AC43 (/ISO) E9ACH0 (/ISO)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
5 Q38BS1 (/IDA) Q38FB8 (/IDA) Q38FB8 (/IDA) Q9U402 (/IDA) Q9U402 (/IDA)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
5 E9AC38 (/ISO) E9AC40 (/ISO) E9AC41 (/ISO) E9AC43 (/ISO) E9ACH0 (/ISO)
Glycosome GO:0020015
A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis.
4 Q38FC0 (/IDA) Q38FC0 (/IDA) Q9U404 (/IDA) Q9U404 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
3 Q1ZXQ4 (/IDA) Q8LKS5 (/IDA) Q8LPS1 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q2I823 (/IDA) Q2I824 (/IDA) Q9T0A0 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
2 Q2I823 (/IDA) Q2I824 (/IDA)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
2 Q9XIA9 (/IDA) Q9XIA9 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
1 Q8LKS5 (/TAS)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q9T0A0 (/IDA)
Lipid droplet GO:0005811
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
1 Q55DR6 (/HDA)
Cytoplasmic side of endosome membrane GO:0010009
The side (leaflet) of the endosome membrane that faces the cytoplasm.
1 Q55DR6 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q8LPS1 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q1ZXQ4 (/IDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 Q55DR6 (/HDA)
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