The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"N-terminal domain of ligase-like
".
FunFam 12: Non-ribosomal peptide synthetase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Acyl carrier activity GO:0000036
Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The acyl carrier protein (ACP) presents substrates to enzymes involved in fatty acid biosynthesis or in polyketide secondary metabolite biosynthesis.
|
4 | P9WQ63 (/IDA) P9WQ63 (/IDA) P9WQ63 (/IDA) P9WQ63 (/IDA) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | P9WQ63 (/IPI) P9WQ63 (/IPI) P9WQ63 (/IPI) P9WQ63 (/IPI) |
Phosphopantetheine binding GO:0031177
Interacting selectively and non-covalently with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate).
|
4 | P9WQ63 (/IDA) P9WQ63 (/IDA) P9WQ63 (/IDA) P9WQ63 (/IDA) |
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
|
2 | Q9I182 (/IMP) Q9I182 (/IMP) |
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
|
1 | Q606B4 (/ISS) |
Acid-amino acid ligase activity GO:0016881
Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
|
1 | Q01886 (/IDA) |
There are 9 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
|
6 | P9WQ63 (/IMP) P9WQ63 (/IMP) P9WQ63 (/IMP) P9WQ63 (/IMP) Q51338 (/IMP) Q51338 (/IMP) |
Cellular response to iron ion starvation GO:0010106
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions.
|
5 | P9WQ63 (/IEP) P9WQ63 (/IEP) P9WQ63 (/IEP) P9WQ63 (/IEP) Q4WF61 (/IEP) |
Nonribosomal peptide biosynthetic process GO:0019184
The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione.
|
5 | Q4WF61 (/ISM) Q4WYP0 (/ISM) Q4WYP0 (/ISM) Q4WZ44 (/ISM) Q4WZ44 (/ISM) |
Secondary metabolic process GO:0019748
The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients.
|
5 | Q4WF61 (/NAS) Q4WYP0 (/NAS) Q4WYP0 (/NAS) Q4WZ44 (/NAS) Q4WZ44 (/NAS) |
Siderophore biosynthetic process from catechol GO:0019540
The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including catechol.
|
4 | P9WQ63 (/IMP) P9WQ63 (/IMP) P9WQ63 (/IMP) P9WQ63 (/IMP) |
Response to host immune response GO:0052572
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
4 | P9WQ63 (/IEP) P9WQ63 (/IEP) P9WQ63 (/IEP) P9WQ63 (/IEP) |
Pyoverdine biosynthetic process GO:0002049
The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine.
|
2 | Q9I182 (/IMP) Q9I182 (/IMP) |
Toxin biosynthetic process GO:0009403
The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.
|
1 | Q01886 (/IDA) |
Nonribosomal peptide biosynthetic process GO:0019184
The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione.
|
1 | Q606B4 (/ISS) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
|
7 | P9WQ63 (/HDA) P9WQ63 (/HDA) P9WQ63 (/HDA) P9WQ63 (/HDA) Q10896 (/HDA) Q10896 (/HDA) Q10896 (/HDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
7 | P9WQ63 (/HDA) P9WQ63 (/HDA) P9WQ63 (/HDA) P9WQ63 (/HDA) Q10896 (/HDA) Q10896 (/HDA) Q10896 (/HDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | Q10896 (/HDA) Q10896 (/HDA) Q10896 (/HDA) |