The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
N-terminal domain of ligase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: Acetyl-coenzyme A synthetase 2-like, mitochondrial

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Acetate-CoA ligase activity GO:0003987
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
4 D3ZZN3 (/IDA) Q99NB1 (/IDA) Q99NB1 (/IDA) Q9NUB1 (/IDA)
Acid-thiol ligase activity GO:0016878
Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
4 Q9KSB8 (/ISS) Q9KSB8 (/ISS) Q9KSB8 (/ISS) Q9KSB8 (/ISS)
Acetate-CoA ligase activity GO:0003987
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
2 Q99NB1 (/ISO) Q99NB1 (/ISO)
Acetate-CoA ligase activity GO:0003987
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
2 Q99NB1 (/ISS) Q99NB1 (/ISS)
Acetate-CoA ligase activity GO:0003987
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
1 Q9NUB1 (/EXP)
Acetate-CoA ligase activity GO:0003987
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
1 Q9H6R3 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q9NUB1 (/IPI)
Short-chain fatty acid-CoA ligase activity GO:0031955
Catalysis of the reaction: ATP + a short-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; short-chain fatty acids are fatty acids with a chain length of less than C6.
1 Q9VC92 (/TAS)
Propionate-CoA ligase activity GO:0050218
Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA.
1 Q5LPB4 (/ISS)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Propionate catabolic process GO:0019543
The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid.
5 Q5LPB4 (/ISS) Q9KSB8 (/ISS) Q9KSB8 (/ISS) Q9KSB8 (/ISS) Q9KSB8 (/ISS)
Acetyl-CoA biosynthetic process GO:0006085
The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.
3 Q99NB1 (/IDA) Q99NB1 (/IDA) Q9NUB1 (/IDA)
Acetyl-CoA biosynthetic process GO:0006085
The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.
2 Q99NB1 (/ISO) Q99NB1 (/ISO)
Acetyl-CoA biosynthetic process GO:0006085
The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.
2 Q99NB1 (/ISS) Q99NB1 (/ISS)
Acetate biosynthetic process GO:0019413
The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid.
2 Q99NB1 (/ISO) Q99NB1 (/ISO)
Propionate biosynthetic process GO:0019542
The chemical reactions and pathways resulting in the formation of propionate, the anion derived from propionic acid.
2 Q99NB1 (/ISO) Q99NB1 (/ISO)
Ethanol oxidation GO:0006069
An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate.
1 Q9NUB1 (/TAS)
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
1 Q9VC92 (/TAS)
Acetate biosynthetic process GO:0019413
The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid.
1 D3ZZN3 (/IDA)
Propionate biosynthetic process GO:0019542
The chemical reactions and pathways resulting in the formation of propionate, the anion derived from propionic acid.
1 D3ZZN3 (/IDA)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
1 Q18496 (/IMP)
Ketone body biosynthetic process GO:0046951
The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA.
1 Q9H6R3 (/TAS)
Regulation of response to oxidative stress GO:1902882
Any process that modulates the frequency, rate or extent of response to oxidative stress.
1 Q18496 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 Q14DH7 (/HDA) Q99NB1 (/HDA) Q99NB1 (/HDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
3 Q99NB1 (/IDA) Q99NB1 (/IDA) Q9NUB1 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q99NB1 (/ISO) Q99NB1 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 Q99NB1 (/ISO) Q99NB1 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 Q99NB1 (/ISS) Q99NB1 (/ISS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 Q9H6R3 (/TAS) Q9NUB1 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 D3ZZN3 (/IDA)
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