The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
N-terminal domain of ligase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Acetyl-coenzyme A synthetase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Acetate-CoA ligase activity GO:0003987
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
71 G3V9U0 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA)
(61 more)
Propionate-CoA ligase activity GO:0050218
Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA.
66 P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA)
(56 more)
Protein deacetylase activity GO:0033558
Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate.
65 P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA)
(55 more)
Acetate-CoA ligase activity GO:0003987
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
16 Q3Z777 (/ISS) Q54Z60 (/ISS) Q554Z5 (/ISS) Q5LSF5 (/ISS) Q606H4 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS)
(6 more)
Acetate-CoA ligase activity GO:0003987
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
3 O94049 (/ISA) O94049 (/ISA) Q8NJN3 (/ISA)
Acid-ammonia (or amide) ligase activity GO:0016880
Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
3 P52910 (/IDA) P52910 (/IDA) Q01574 (/IDA)
3-hydroxypropionyl-CoA synthetase activity GO:0043955
Catalysis of the reaction: 3-hydroxypropionate + ATP + CoA = 3-hydroxypropionyl-CoA + AMP + diphosphate.
3 A4YGR1 (/IDA) A4YGR1 (/IDA) Q973W5 (/IDA)
Acetate-CoA ligase activity GO:0003987
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
2 P78773 (/ISO) Q9QXG4 (/ISO)
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
1 Q57XD7 (/ISM)
Acetate-CoA ligase activity GO:0003987
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
1 Q8NJN3 (/IGI)
Acetate-CoA ligase activity GO:0003987
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
1 B9DGD6 (/IMP)
Acetate-CoA ligase activity GO:0003987
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
1 P16928 (/RCA)
Acetate-CoA ligase activity GO:0003987
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
1 Q9NR19 (/TAS)
AMP binding GO:0016208
Interacting selectively and non-covalently with AMP, adenosine monophosphate.
1 Q9NR19 (/IC)
AMP binding GO:0016208
Interacting selectively and non-covalently with AMP, adenosine monophosphate.
1 P78773 (/ISM)
AMP binding GO:0016208
Interacting selectively and non-covalently with AMP, adenosine monophosphate.
1 Q54Z60 (/ISS)
Short-chain fatty acid-CoA ligase activity GO:0031955
Catalysis of the reaction: ATP + a short-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; short-chain fatty acids are fatty acids with a chain length of less than C6.
1 Q9VP61 (/TAS)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Acetate catabolic process GO:0045733
The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid.
66 P16928 (/IMP) P27550 (/IMP) P27550 (/IMP) P27550 (/IMP) P27550 (/IMP) P27550 (/IMP) P27550 (/IMP) P27550 (/IMP) P27550 (/IMP) P27550 (/IMP)
(56 more)
Peptidyl-lysine acetylation GO:0018394
The acetylation of peptidyl-lysine.
65 P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA)
(55 more)
Post-translational protein acetylation GO:0034421
The addition of an acetyl group to one or more amino acids in a protein, occurring after the protein has been completely translated and released from the ribosome.
65 P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA)
(55 more)
Acetyl-CoA biosynthetic process from acetate GO:0019427
The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate.
12 Q3Z777 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS) Q8EDK3 (/ISS)
(2 more)
Acetyl-CoA biosynthetic process GO:0006085
The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.
4 P52910 (/IDA) P52910 (/IDA) Q01574 (/IDA) Q9QXG4 (/IDA)
Acetyl-CoA biosynthetic process GO:0006085
The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.
3 O94049 (/ISA) O94049 (/ISA) Q8NJN3 (/ISA)
Carbon fixation by 3-hydroxypropionate cycle GO:0043427
An autotrophic carbon dioxide fixation pathway by which two molecules of carbon dioxide are fixed to form glyoxylate. Acetyl coenzyme A (acetyl-CoA) is assumed to be converted to malate, and two CO2 molecules are thereby fixed. Malyl-CoA is thought to be cleaved to acetyl-CoA, the starting molecule, and glyoxylate, the carbon fixation product.
3 A4YGR1 (/IDA) A4YGR1 (/IDA) Q973W5 (/IDA)
Replicative cell aging GO:0001302
The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division.
2 P52910 (/IMP) P52910 (/IMP)
Acetyl-CoA biosynthetic process GO:0006085
The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.
2 Q3Z777 (/ISS) Q54Z60 (/ISS)
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
2 P52910 (/IMP) P52910 (/IMP)
Ethanol oxidation GO:0006069
An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate.
1 Q9NR19 (/TAS)
Acetate metabolic process GO:0006083
The chemical reactions and pathways involving acetate, the anion of acetic acid.
1 B9DGD6 (/IMP)
Acetate metabolic process GO:0006083
The chemical reactions and pathways involving acetate, the anion of acetic acid.
1 P16928 (/RCA)
Acetyl-CoA biosynthetic process GO:0006085
The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.
1 Q8NJN3 (/IGI)
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
1 Q9VP61 (/TAS)
Lipid biosynthetic process GO:0008610
The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
1 Q9NR19 (/IMP)
Lipid biosynthetic process GO:0008610
The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
1 Q9QXG4 (/ISO)
Lipid biosynthetic process GO:0008610
The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
1 Q554Z5 (/ISS)
Aerobic respiration GO:0009060
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
1 Q5LSF5 (/ISS)
Carbon utilization GO:0015976
A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism.
1 P16928 (/IMP)
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
1 Q01574 (/IGI)
Isopentenyl diphosphate biosynthetic process, mevalonate pathway GO:0019287
The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates.
1 Q606H4 (/ISS)
Acetate biosynthetic process GO:0019413
The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid.
1 G3V9U0 (/IDA)
Acetate biosynthetic process GO:0019413
The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid.
1 Q9QXG4 (/ISO)
Propionate biosynthetic process GO:0019542
The chemical reactions and pathways resulting in the formation of propionate, the anion derived from propionic acid.
1 G3V9U0 (/IDA)
Propionate biosynthetic process GO:0019542
The chemical reactions and pathways resulting in the formation of propionate, the anion derived from propionic acid.
1 Q9QXG4 (/ISO)
Acetate fermentation GO:0019654
The anaerobic chemical reactions and pathways resulting in the breakdown of acetate, yielding energy in the form of ATP.
1 Q01574 (/IMP)
Propionate metabolic process, methylcitrate cycle GO:0019679
The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle.
1 P16928 (/RCA)
Behavioral response to ethanol GO:0048149
Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus.
1 Q9VP61 (/IMP)

There are 28 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
72 B9DGD6 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA)
(62 more)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
9 P9WQD1 (/HDA) P9WQD1 (/HDA) P9WQD1 (/HDA) P9WQD1 (/HDA) P9WQD1 (/HDA) P9WQD1 (/HDA) P9WQD1 (/HDA) P9WQD1 (/HDA) P9WQD1 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 P9WQD1 (/HDA) P9WQD1 (/HDA) P9WQD1 (/HDA) P9WQD1 (/HDA) P9WQD1 (/HDA) P9WQD1 (/HDA) P9WQD1 (/HDA) P9WQD1 (/HDA) P9WQD1 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 G3V9U0 (/IDA) P78773 (/IDA) Q57XD7 (/IDA) Q9QXG4 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P52910 (/IDA) P52910 (/IDA) P78773 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q4QBC0 (/ISO) Q9QXG4 (/ISO) Q9U0W1 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 O94049 (/ISA) O94049 (/ISA) Q8NJN3 (/ISA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 P52910 (/IDA) P52910 (/IDA)
Nuclear lumen GO:0031981
The volume enclosed by the nuclear inner membrane.
2 Q4QBC0 (/ISO) Q9U0W1 (/ISO)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
2 Q4QBC0 (/ISO) Q9U0W1 (/ISO)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P16928 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P78773 (/HDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9NR19 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9QXG4 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9NR19 (/IC)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q01574 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P78773 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q9NR19 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P78773 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8NJN3 (/IGI)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9QXG4 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9NR19 (/TAS)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 B9DGD6 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
1 B9DGD6 (/IDA)
Nuclear lumen GO:0031981
The volume enclosed by the nuclear inner membrane.
1 Q57XD7 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q9NR19 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q9QXG4 (/ISO)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
1 Q57XD7 (/IDA)
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