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CATH Superfamily 3.40.50.12500

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Putative hydantoin racemase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Hydantoin racemase. [EC: 5.1.99.5]
D-5-monosubstituted hydantoin = L-5-monosubstituted hydantoin.
  • This enzyme, along with EC 3.5.1.77, EC 3.5.1.87 and EC 3.5.2.2, forms part of the reaction cascade known as the 'hydantoinase process', which allows the total conversion of D,L-5-monosubstituted hydantoins into optically pure D- or L-amino acids.
  • The enzyme from Pseudomonas sp. (HyuE) has a preference for hydantoins with aliphatic substituents, e.g. D- and L-5- (2-(methylsulfanyl)ethyl)hydantoin, whereas that from Arthrobacter aurescens shows highest activity with arylalkyl substituents, especially 5-benzylhydantoin, at the 5-position.
  • In the enzyme from Sinorhizobium meliloti, Cys-76 is responsible for recognition and proton retrieval of D-isomers, while Cys-181 is responsible for L-isomer recognition and racemization.
 38 A0A222JVI2 A0A222JVI2 A0A222JVI2 A0A222JVI2 A0A222JVI2 A0A222JVI2 A0A2T3EN86 A0A2T3EN86 A0A2T3EN86 A0A2T3EN86
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