CATH Superfamily 3.40.50.11990
RNA polymerase II accessory factor, Cdc73 C-terminal domain
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"RNA polymerase II accessory factor, Cdc73 C-terminal domain
".
FunFam 5: Cell division cycle-related protein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
RNA polymerase II complex binding GO:0000993
Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.
|
2 | Q06697 (/IPI) Q06697 (/IPI) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
2 | Q06697 (/IDA) Q06697 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q06697 (/IPI) Q06697 (/IPI) |
|
RNA polymerase II C-terminal domain phosphoserine binding GO:1990269
Interacting selectively and non-covalently with phosphorylated serine residues in the C-terminal domain of RNA polymerase II.
|
2 | Q06697 (/IDA) Q06697 (/IDA) |
There are 11 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transcription elongation from RNA polymerase I promoter GO:0006362
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I.
|
2 | Q06697 (/IMP) Q06697 (/IMP) |
|
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
|
2 | Q06697 (/IGI) Q06697 (/IGI) |
|
MRNA 3'-end processing GO:0031124
Any process involved in forming the mature 3' end of an mRNA molecule.
|
2 | Q06697 (/IMP) Q06697 (/IMP) |
|
Positive regulation of transcription elongation from RNA polymerase II promoter GO:0032968
Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
|
2 | Q06697 (/IMP) Q06697 (/IMP) |
|
Recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex GO:0034402
The process in which proteins required for 3'-end transcript processing become associated with the RNA polymerase II holoenzyme complex and the 3' end of a transcript.
|
2 | Q06697 (/IMP) Q06697 (/IMP) |
|
Negative regulation of DNA recombination GO:0045910
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.
|
2 | Q06697 (/IMP) Q06697 (/IMP) |
|
Regulation of transcription-coupled nucleotide-excision repair GO:0090262
Any process that modulates the frequency, rate, or extent of the nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway.
|
2 | Q06697 (/IGI) Q06697 (/IGI) |
|
Positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues GO:2001165
Any process that activates or increases the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues.
|
2 | Q06697 (/IMP) Q06697 (/IMP) |
|
Regulation of histone H2B conserved C-terminal lysine ubiquitination GO:2001173
Any process that modulates the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination.
|
2 | Q06697 (/IDA) Q06697 (/IDA) |
|
Positive regulation of transcription elongation from RNA polymerase I promoter GO:2001209
Any process that activates or increases the frequency, rate or extent of transcription elongation from RNA polymerase I promoter.
|
2 | Q06697 (/IDA) Q06697 (/IDA) |
|
Positive regulation of histone H3-K36 trimethylation GO:2001255
Any process that activates or increases the frequency, rate or extent of histone H3-K36 trimethylation.
|
2 | Q06697 (/IMP) Q06697 (/IMP) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q06697 (/IDA) Q06697 (/IDA) |
|
Cdc73/Paf1 complex GO:0016593
A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p.
|
2 | Q06697 (/IPI) Q06697 (/IPI) |
|
Transcriptionally active chromatin GO:0035327
The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed.
|
2 | Q06697 (/IDA) Q06697 (/IDA) |
