View in Gene3D

CATH Superfamily 3.40.50.10990

GTP cyclohydrolase II

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
GTP cyclohydrolase II
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 11: 3,4-dihydroxy-2-butanone 4-phosphate synthase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3,4-dihydroxy-2-butanone-4-phosphate synthase. [EC: 4.1.99.12]
D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate.
  • The reaction involves an intramolecular skeletal rearrangement, with the bonds in D-ribulose 5-phosphate that connect C-3 and C-5 to C-4 being broken, C-4 being removed as formate and reconnection of C-3 and C-5.
  • The phosphorylated four-carbon product (L-3,4-dihydroxybutan-2-one 4-phosphate) is an intermediate in the biosynthesis of riboflavin.
 13 A0A1W0VP79 A0A1W0VP79 A0A1Y3E0I8 A0A1Y3E0I8 A0A1Y3E0I8 A0A2J9KIW7 A0A2J9KIW7 A0A2J9KIW7 O25484 O25484
(3 more...)
CATH-Gene3D is a Global Biodata Core Resource Learn more...