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CATH Superfamily 3.40.50.10820

Inositol 1,3,4-trisphosphate 5/6-kinase domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Inositol 1,3,4-trisphosphate 5/6-kinase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Inositol-tetrakisphosphate 1-kinase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Inositol-tetrakisphosphate 1-kinase. [EC: 2.7.1.134]
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.
  • This enzyme also phosphorylates Ins(1,3,4)P(3) on O-5 and O-6.
  • The phosphotransfer from ATP to either inositol 1,3,4-trisphosphate or inositol 3,4,5,6-tetrakisphosphate appears to be freely reversible to the extent that the enzyme can act like an inositol polyphosphate phosphatase in the presence of ADP.
  • It can also catalyze an isomerization between Ins(1,3,4,5)P(4) and Ins(1,3,4,6)P(4) in the presence of ADP.
  • Formerly EC 2.7.1.133 and EC 2.7.1.139.
 36 A0A175JN23 A0A175JN23 A0A175JN23 A0A175JN23 A0A175JN23 A0A175JN23 M2S7J7 M2S7J7 M2S7J7 M2S7J7
(26 more...)
Inositol-1,3,4-trisphosphate 5/6-kinase. [EC: 2.7.1.159]
(1) ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate. (2) ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate.
  • In humans, this enzyme, along with EC 2.7.1.127, EC 2.7.1.140 and EC 2.7.1.158 is involved in the production of inositol hexakisphosphate (InsP(6)).
  • InsP(6) is involved in many cellular processes, including mRNA export from the nucleus.
  • Yeast do not have this enzyme, so produce InsP(6) from Ins(1,4,5)P(3) by the actions of EC 2.7.1.151 and EC 2.7.1.158.
 36 A0A175JN23 A0A175JN23 A0A175JN23 A0A175JN23 A0A175JN23 A0A175JN23 M2S7J7 M2S7J7 M2S7J7 M2S7J7
(26 more...)
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