The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Tandem AAA-ATPase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 7: Chromodomain-helicase-DNA-binding protein 2 isofor...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 27 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 E9PZM4 (/IPI) O14139 (/IPI) O14646 (/IPI) O14647 (/IPI) Q9US25 (/IPI)
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
3 O14646 (/IDA) P32657 (/IDA) P32657 (/IDA)
Nucleosome-dependent ATPase activity GO:0070615
Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of one or more nucleosomes.
3 O14139 (/IDA) P32657 (/IDA) P32657 (/IDA)
RDNA binding GO:0000182
Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA.
2 P32657 (/IDA) P32657 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 P32657 (/IDA) P32657 (/IDA)
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
2 O14646 (/TAS) O14647 (/TAS)
DNA-dependent ATPase activity GO:0008094
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction.
2 P32657 (/IDA) P32657 (/IDA)
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
2 P32657 (/IDA) P32657 (/IDA)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
2 P32657 (/IDA) P32657 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 E9PZM4 (/IMP)
Showing 1 to 10 of 27 entries

There are 46 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Termination of RNA polymerase II transcription GO:0006369
The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed.
3 P32657 (/IMP) P32657 (/IMP) Q9US25 (/IMP)
Nucleosome organization GO:0034728
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes.
3 O14139 (/IMP) P32657 (/IMP) P32657 (/IMP)
Regulation of transcriptional start site selection at RNA polymerase II promoter GO:0001178
Any process that modulates the rate, frequency or extent of a process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
2 P32657 (/IGI) P32657 (/IGI)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 O14646 (/TAS) O14647 (/TAS)
Termination of RNA polymerase I transcription GO:0006363
The process in which the synthesis of an RNA molecule by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit.
2 P32657 (/IGI) P32657 (/IGI)
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
2 P32657 (/IGI) P32657 (/IGI)
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
2 P32657 (/IPI) P32657 (/IPI)
Termination of RNA polymerase II transcription GO:0006369
The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed.
2 P32657 (/IGI) P32657 (/IGI)
Nucleosome positioning GO:0016584
Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another.
2 P32657 (/IDA) P32657 (/IDA)
Chromatin silencing at silent mating-type cassette GO:0030466
Repression of transcription at silent mating-type loci by alteration of the structure of chromatin.
2 O14139 (/IMP) Q9US25 (/IMP)
Showing 1 to 10 of 46 entries

There are 26 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 E9PZM4 (/IDA) O14646 (/IDA) O14647 (/IDA) Q9US25 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
3 P32657 (/IDA) P32657 (/IDA) Q9US25 (/IDA)
SAGA complex GO:0000124
A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8.
2 P32657 (/IDA) P32657 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 E9PZM4 (/ISO) P40201 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 A0A024RC75 (/IDA) O14647 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P32657 (/HDA) P32657 (/HDA)
Nucleolar chromatin GO:0030874
The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA.
2 P32657 (/IDA) P32657 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 A0A024RC75 (/IDA) O14647 (/IDA)
SLIK (SAGA-like) complex GO:0046695
A SAGA-type histone acetyltransferase complex that contains Rtg2 and a smaller form of Spt7 than the fungal SAGA complex, and lacks Spt8. The complex is involved in the yeast retrograde response pathway, which is important for gene expression changes during mitochondrial dysfunction.
2 P32657 (/IDA) P32657 (/IDA)
Condensed nuclear chromosome, centromeric region GO:0000780
The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
1 Q9US25 (/IDA)
Showing 1 to 10 of 26 entries
CATH-Gene3D is a Global Biodata Core Resource Learn more...