The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Probable brix-domain ribosomal biogenesis protein
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: IMP4, U3 small nucleolar ribonucleoprotein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 P53941 (/IPI) P53941 (/IPI) P53941 (/IPI) P53941 (/IPI) P53941 (/IPI) P53941 (/IPI) Q96G21 (/IPI) Q9VBY2 (/IPI)
SnoRNA binding GO:0030515
Interacting selectively and non-covalently with small nucleolar RNA.
6 P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) P53941 (/IDA)
RRNA primary transcript binding GO:0042134
Interacting selectively and non-covalently with an unprocessed ribosomal RNA transcript.
6 P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) P53941 (/IDA)
Single-stranded telomeric DNA binding GO:0043047
Interacting selectively and non-covalently with single-stranded telomere-associated DNA.
6 P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) P53941 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 O13823 (/ISS)
SnoRNA binding GO:0030515
Interacting selectively and non-covalently with small nucleolar RNA.
1 C7G018 (/ISS)

There are 8 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
6 P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) P53941 (/IDA)
RRNA methylation GO:0031167
The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule.
6 P53941 (/TAS) P53941 (/TAS) P53941 (/TAS) P53941 (/TAS) P53941 (/TAS) P53941 (/TAS)
Ribosomal small subunit biogenesis GO:0042274
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.
6 P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) P53941 (/IDA)
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
3 Q96G21 (/TAS) Q9S826 (/TAS) Q9S826 (/TAS)
RNA processing GO:0006396
Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
3 Q8IB23 (/ISS) Q8IB23 (/ISS) Q8IB23 (/ISS)
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
1 O13823 (/ISO)
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
1 C7G018 (/ISS)
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
1 Q96G21 (/NAS)

There are 22 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
8 B8ZZ47 (/IDA) B8ZZ47 (/IDA) B9A008 (/IDA) B9A008 (/IDA) B9A008 (/IDA) E7ENR5 (/IDA) H0Y714 (/IDA) Q96G21 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
7 P53941 (/TAS) P53941 (/TAS) P53941 (/TAS) P53941 (/TAS) P53941 (/TAS) P53941 (/TAS) Q96G21 (/TAS)
Mpp10 complex GO:0034457
A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Mpp10p, Imp3p and Imp4p.
7 P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) Q96G21 (/IDA)
90S preribosome GO:0030686
A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
6 P53941 (/HDA) P53941 (/HDA) P53941 (/HDA) P53941 (/HDA) P53941 (/HDA) P53941 (/HDA)
Small-subunit processome GO:0032040
A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
6 P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) P53941 (/IDA) P53941 (/IDA)
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
4 B8ZZ47 (/IDA) B8ZZ47 (/IDA) H0Y714 (/IDA) Q96G21 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
3 O13823 (/HDA) Q95SD3 (/HDA) Q9VBY2 (/HDA)
Small nucleolar ribonucleoprotein complex GO:0005732
A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type.
3 Q8IB23 (/ISS) Q8IB23 (/ISS) Q8IB23 (/ISS)
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
2 Q8VHZ7 (/ISO) Q8VHZ7 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q95SD3 (/HDA) Q9VBY2 (/HDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 Q8VHZ7 (/ISO) Q8VHZ7 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 Q8VHZ7 (/ISS) Q8VHZ7 (/ISS)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 Q9S826 (/TAS) Q9S826 (/TAS)
Small nucleolar ribonucleoprotein complex GO:0005732
A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type.
2 Q9S826 (/TAS) Q9S826 (/TAS)
Cajal body GO:0015030
A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.
2 Q9S826 (/TAS) Q9S826 (/TAS)
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
2 Q9S826 (/IDA) Q9S826 (/IDA)
Preribosome GO:0030684
Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis.
2 Q8VHZ7 (/ISO) Q8VHZ7 (/ISO)
Mpp10 complex GO:0034457
A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Mpp10p, Imp3p and Imp4p.
2 Q8VHZ7 (/ISO) Q8VHZ7 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O13823 (/HDA)
Preribosome GO:0030684
Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis.
1 Q96G21 (/IDA)
Small-subunit processome GO:0032040
A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
1 O13823 (/ISO)
Mpp10 complex GO:0034457
A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Mpp10p, Imp3p and Imp4p.
1 C7G018 (/ISS)
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