The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Translation initiation factor eif-2b; domain 2
".
FunFam 4: Translation initiation factor eIF-2B subunit beta
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | P49770 (/IPI) P49770 (/IPI) Q53XC2 (/IPI) Q53XC2 (/IPI) Q9BPX4 (/IPI) |
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
5 | Q28690 (/ISS) Q5E9B4 (/ISS) Q62818 (/ISS) Q90511 (/ISS) Q99LD9 (/ISS) |
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
5 | Q28690 (/ISS) Q5E9B4 (/ISS) Q62818 (/ISS) Q90511 (/ISS) Q99LD9 (/ISS) |
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
2 | P49770 (/IDA) P49770 (/IDA) |
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
2 | P49770 (/IDA) P49770 (/IDA) |
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | Q99LD9 (/ISO) |
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
1 | Q99LD9 (/ISO) |
There are 32 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
|
5 | Q28690 (/ISS) Q5E9B4 (/ISS) Q62818 (/ISS) Q90511 (/ISS) Q99LD9 (/ISS) |
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
|
5 | Q28690 (/ISS) Q5E9B4 (/ISS) Q62818 (/ISS) Q90511 (/ISS) Q99LD9 (/ISS) |
Oligodendrocyte development GO:0014003
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
|
5 | Q28690 (/ISS) Q5E9B4 (/ISS) Q62818 (/ISS) Q90511 (/ISS) Q99LD9 (/ISS) |
Myelination GO:0042552
The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
|
5 | Q28690 (/ISS) Q5E9B4 (/ISS) Q62818 (/ISS) Q90511 (/ISS) Q99LD9 (/ISS) |
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
|
5 | Q28690 (/ISS) Q5E9B4 (/ISS) Q62818 (/ISS) Q90511 (/ISS) Q99LD9 (/ISS) |
Ovarian follicle development GO:0001541
The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.
|
4 | Q28690 (/ISS) Q5E9B4 (/ISS) Q62818 (/ISS) Q99LD9 (/ISS) |
Ovarian follicle development GO:0001541
The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.
|
2 | P49770 (/IMP) P49770 (/IMP) |
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
|
2 | P49770 (/IDA) P49770 (/IDA) |
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
|
2 | P49770 (/TAS) P49770 (/TAS) |
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
|
2 | P49770 (/IMP) P49770 (/IMP) |
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
2 | P49770 (/ISS) P49770 (/ISS) |
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
2 | P49770 (/TAS) P49770 (/TAS) |
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
|
2 | P49770 (/ISS) P49770 (/ISS) |
Oligodendrocyte development GO:0014003
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
|
2 | P49770 (/IMP) P49770 (/IMP) |
Myelination GO:0042552
The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
|
2 | P49770 (/IMP) P49770 (/IMP) |
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
|
2 | P49770 (/ISS) P49770 (/ISS) |
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
|
2 | P49770 (/IDA) P49770 (/IDA) |
Ovarian follicle development GO:0001541
The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.
|
1 | Q99LD9 (/ISO) |
Translational initiation GO:0006413
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
|
1 | Q99LD9 (/ISO) |
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
|
1 | Q99LD9 (/ISO) |
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
1 | Q62818 (/IDA) |
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
1 | Q99LD9 (/ISO) |
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
|
1 | Q62818 (/IDA) |
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
|
1 | Q99LD9 (/ISO) |
Oligodendrocyte development GO:0014003
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
|
1 | Q99LD9 (/ISO) |
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
|
1 | Q62818 (/IEP) |
Myelination GO:0042552
The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
|
1 | Q99LD9 (/ISO) |
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
|
1 | Q62818 (/IDA) |
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
|
1 | Q99LD9 (/ISO) |
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
|
1 | Q62818 (/IMP) |
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
|
1 | Q99LD9 (/ISO) |
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
|
1 | Q99LD9 (/ISO) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
5 | Q28690 (/ISS) Q5E9B4 (/ISS) Q62818 (/ISS) Q90511 (/ISS) Q99LD9 (/ISS) |
Eukaryotic translation initiation factor 2B complex GO:0005851
A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.
|
5 | Q28690 (/ISS) Q5E9B4 (/ISS) Q62818 (/ISS) Q90511 (/ISS) Q99LD9 (/ISS) |
Eukaryotic translation initiation factor 2B complex GO:0005851
A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.
|
3 | P49770 (/IDA) P49770 (/IDA) Q62818 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P49770 (/IDA) P49770 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | P49770 (/TAS) P49770 (/TAS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q99LD9 (/ISO) |
Eukaryotic translation initiation factor 2B complex GO:0005851
A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.
|
1 | Q62818 (/IPI) |
Eukaryotic translation initiation factor 2B complex GO:0005851
A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.
|
1 | Q99LD9 (/ISO) |
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
1 | Q62818 (/IDA) |
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
1 | Q99LD9 (/ISO) |