The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Toll/interleukin-1 receptor homology (TIR) domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 15: Toll/interleukin-1 receptor domain-containing adap...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P58753 (/IPI) P58753 (/IPI) P58753 (/IPI) P58753 (/IPI) Q99JY1 (/IPI)
Toll-like receptor 2 binding GO:0035663
Interacting selectively and non-covalently with a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response.
5 P58753 (/IPI) P58753 (/IPI) P58753 (/IPI) P58753 (/IPI) Q99JY1 (/IPI)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
5 P58753 (/IDA) P58753 (/IDA) P58753 (/IDA) P58753 (/IDA) Q99JY1 (/IDA)
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
4 P58753 (/IPI) P58753 (/IPI) P58753 (/IPI) P58753 (/IPI)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
4 P58753 (/ISS) P58753 (/ISS) P58753 (/ISS) P58753 (/ISS)
Protein binding, bridging GO:0030674
The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
4 P58753 (/NAS) P58753 (/NAS) P58753 (/NAS) P58753 (/NAS)
Toll-like receptor 4 binding GO:0035662
Interacting selectively and non-covalently with a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response.
4 P58753 (/IPI) P58753 (/IPI) P58753 (/IPI) P58753 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 P58753 (/IPI) P58753 (/IPI) P58753 (/IPI) P58753 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
4 P58753 (/ISS) P58753 (/ISS) P58753 (/ISS) P58753 (/ISS)
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
1 Q99JY1 (/ISO)
Showing 1 to 10 of 17 entries

There are 73 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Positive regulation of interleukin-8 production GO:0032757
Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.
5 P58753 (/IMP) P58753 (/IMP) P58753 (/IMP) P58753 (/IMP) Q99JY1 (/IMP)
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
5 P58753 (/IMP) P58753 (/IMP) P58753 (/IMP) P58753 (/IMP) Q99JY1 (/IMP)
Positive regulation of interleukin-6 biosynthetic process GO:0045410
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.
5 P58753 (/IMP) P58753 (/IMP) P58753 (/IMP) P58753 (/IMP) Q99JY1 (/IMP)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
5 P58753 (/IMP) P58753 (/IMP) P58753 (/IMP) P58753 (/IMP) Q99JY1 (/IMP)
MyD88-dependent toll-like receptor signaling pathway GO:0002755
Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
4 P58753 (/TAS) P58753 (/TAS) P58753 (/TAS) P58753 (/TAS)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
4 P58753 (/ISS) P58753 (/ISS) P58753 (/ISS) P58753 (/ISS)
Activation of NF-kappaB-inducing kinase activity GO:0007250
The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues.
4 P58753 (/IMP) P58753 (/IMP) P58753 (/IMP) P58753 (/IMP)
Myeloid cell differentiation GO:0030099
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
4 P58753 (/ISS) P58753 (/ISS) P58753 (/ISS) P58753 (/ISS)
Positive regulation of B cell proliferation GO:0030890
Any process that activates or increases the rate or extent of B cell proliferation.
4 P58753 (/ISS) P58753 (/ISS) P58753 (/ISS) P58753 (/ISS)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
4 P58753 (/IDA) P58753 (/IDA) P58753 (/IDA) P58753 (/IDA)
Showing 1 to 10 of 73 entries

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 P58753 (/IDA) P58753 (/IDA) P58753 (/IDA) P58753 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 P58753 (/TAS) P58753 (/TAS) P58753 (/TAS) P58753 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P58753 (/IDA) P58753 (/IDA) P58753 (/IDA) P58753 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P58753 (/TAS) P58753 (/TAS) P58753 (/TAS) P58753 (/TAS)
Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
4 P58753 (/ISS) P58753 (/ISS) P58753 (/ISS) P58753 (/ISS)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
4 P58753 (/ISS) P58753 (/ISS) P58753 (/ISS) P58753 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q99JY1 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q99JY1 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q99JY1 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q99JY1 (/ISS)
Showing 1 to 10 of 12 entries
CATH-Gene3D is a Global Biodata Core Resource Learn more...